{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mNCWHvpX3nRagI+YmFifLMXaKTRtcM6IY73s+31LuK7pi3HuGWHMUm53muntwN8TDboI7M0XR2TpaOUZ\\\\\\\\\\\\\\\/Gx8U+pxcXW4zceryBrPDrkLQZUldBfula9nE+Ywyc4BRImfKbcnU99t3rSyg5zjVncrnLI9vynLV1\\\\\\\\\\\\\\\/quMJ69a3op6oK39pGmTIKn5IltXAyS7TUvpvZnWjcE7m3KaBotMbMd1zMDf8gMXGxpVnGdDJ2zqabtQ1gEExX69kEY6+Eq1fWhT8dOegpw4suvl2krkHxi72tyvMN9k+vw2cbB75zm3Ch3rJrZ5hWaT2MZkhAuNw9Swd\\\\\\\\\\\\\\\/YTEJJzulIuCV0DhkTeeiMYFmS9j0S4GlkWo3KwE+BoaSPLji+b2EmMRRKh\\\\\\\\\\\\\\\/+1EYSsnh5yB7mzAmnA+A0iwGmDFzCoSqVI2zRqjLBNK\\\\\\\\\\\\\\\/MRirlItrvvmzKUAsu1NyyDhEZf0j+gMnA5CrPgmbqYlslcvmgqn0tm3eOeVw9FovAurFXc8LVXUtkOzRai\\\\\\\\\\\\\\\/oLl81X6weaZ17Vg\\\\\\\\\\\\\\\/uwc3LPpMdvrKi70txllhURffgG3HEaxMRnhWAkB9WZ9PnsCXF5A7akJnrg5GZ+\\\\\\\\\\\\\\\/n0BpwSVD7yVGO\\\\\\\\\\\\\\\/Spq8TvxybChi3VDY2mqxpVieGMI94NJG6qC\\\\\\\\\\\\\\\/TnEJy3Kn1eLBGdcmf3+gHmFK95TNQgPlFfOB+dsN2JobtNsQuPdC6BmhuzFdRvkk23McM\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/iSJFJ5BWswe3fBoF222W2sjyRswa7WLi7+8RMEEAZ0Pn2CWVoyQ5NXweJnkJOauvXYBN+E5V74V+kkmkmwAuw7PZNdWYCiIlVJuFRUziQ99HrR8gvNERpLN9O6WHCSZhQ+cGRjkWI3u9Q66q+XWdJei0khH1LYg2oELjNVixtmnazT3CRDxIpW+bdFTplwuvhhgx6rtXlvpP1Dgb\\\\\\\\\\\\\\\/G1xdnlhAN7kNRQRcLeL+DtyHH+K5jvj1EslBCrq6p0qVDunaSinBX3oe3LIYbwcBPGqt5d0VWpLLZaKMBzEuKA3PQpCJNRazTP6i0OPnpBTdM6vg29QtK0eornUOYI5nMZhbfJRfWN80uftxvuOcyvtg\\\\\\\\\\\\\\\/M3Y2+zaMV9O08nggsqQcQa5LJujrEumhmWu9SggEh9BH68Ef+UuttR0NoO4P6uGZkuVrFiiNDqHIfoM3ENEfylIISMewcFolNVV8Ozw3H6QJP2jvgBDi1IpXCD+rx18tdW4VfMEE1lrSZvBu16JFH\\\\\\\\\\\\\\\/3A0o14RR0SqtCD3EA64MWfgpRAI1fG0Irhb+\\\\\\\\\\\\\\\/Nhf9X\\\\\\\\\\\\\\\/fCyXUNVIiB9XmZA982+cuuBuzdPXpRpBLOeK143bVLAnu8oVwoClHiuWpw3PLsrRxdKzooQtGoQ3fn\\\\\\\\\\\\\\\/3w3X6C3eosOpro8KzyK7fR0OM7YiOVpQ\\\\\\\\\\\\\\\/b86VxVxR+lcGynrB\\\\\\\\\\\\\\\/gsPm4bLV5l8tsqjvWQ2TOiQtUJHZpTC3VseidhXpGe+WGJBrZFvMJFLcieVV9tVTmh\\\\\\\\\\\\\\\/Mb6EznWtPkbWeknr3f574tK5IZtf6jB76U3V5vBD6OPA9DrAIsg0HQoDbXjJSiYprY1uqQmNv+dzv9LtahZ4aFdek2+vRGjnJiiAfso2bKd5bTu3l7RjL7Zpjrw5rIso3I0AvsNHmbZJMXlbAbRMGUfohV+at2BKp0CAGIUsJYVtTBCKLLrOtL+CjYK7vJPPZ13IVdv0Zq+FvfrNKqfJz3ELbpzDFxrPeusP\\\\\\\\\\\\\\\/k91wrfkscvSTqalT+v+YS05hdn0LI68J\\\\\\\\\\\\\\\/qxEjYA9mBF2\\\\\\\\\\\\\\\/LcS7nm0\\\\\\\\\\\\\\\/mYT2uee4g2nlpnJrRUCG4ZEVKmxLQmPyzk0Nxn0BJd\\\\\\\\\\\\\\\/2N2UO55G+E8XbFg89EfK6jYAWsXllqqHF538m5cIKJ\\\\\\\\\\\\\\\/5y8Ix0rFr5lDLOP2fmkVuxThUmIV2kySM+798ulrK9XFLk06jPVDh+hc1\\\\\\\\\\\\\\\/N+AnMZfNt55mTjujtG1MrDPP254aNtx2pRkV8P77EBtLZo+J9Lh9fZek6D8Pz7YuDot5GdBq4xO6sPe5Ib1H4BPeQ4gfV4+qMucp8NX5wpNLKskiDhP4WRolykXKU7F46m2BuTAHdJm4L5CEyfptMiWgBBUmtsTv0oLWUqSSQPexWr9QnOVNv78TVvL1tTsXvspGbOv3CgFma+xoaRt+heJMjixEboeii4Nje4\\\\\\\\\\\\\\\/6d7Lk+0x61eTGORiwB3hRrkejXHLXMIYHp0slZKP1SE9O4\\\\\\\\\\\\\\\/n3V5G0hvwBGEGUFnEyzB3InYwp7jvMgFsz4YBwwwMau9WU1qlfKY1cf58WXWX\\\\\\\\\\\\\\\/v7n0w7e4jxcbaO7HTscLfZhnF\\\\\\\\\\\\\\\/0wvw0E6WmlPy2Mz6pegsb47m+65mWFhrj7DghqT8jYhdeimwGFamMz\\\\\\\\\\\\\\\/NLjKDCoxFTQLLul+CUmIKKx8N7HHYXdojH3dcE\\\\\\\\\\\\\\\/Jm1P7rA4Mu4tCWOoAWBet15PXuZh40I6qSSYRu1udYBegdGGNBD6GGr+7FbrSLJjQTA3yfPrsyMLMfICcDJyETzaqYewhkw51oupgOyDhyVyLGn58ocVZDjwWNEaO6JvCmRkEJCUAZS88xRioi2iOlonmX4dSvJ0Vp7Ngq6YL80Z9q7z7\\\\\\\\\\\\\\\/b4nwvxyfl+c377z\\\\\\\\\\\\\\\/eqFY2tJEmZOQYzRgEJ4ASZhzgVUWk+BAL10xTbQC6TsFokL7kPQRTfHka0BB7A=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022LwhAxgTUAI+CIQ3huryPvg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022cd900753a8be82c62adebc66fa6aadd7e372e7785b25de8328bdb514be0ed99c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/3\\\/1\\\/9.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/3\\\/1\\\/9.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1186\/s40425-015-0053-5\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1186\/s40425-015-0053-5\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1186\/s40425-015-0053-5\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}