{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022YO53ZSiAvoV8fX+gW8K631ebDsPGeFNrBYfrm1J+t9noVYreO8+fHDqSsewDwyLoQoaGSYSZB0F1qZSR\\\\\\\\\\\\\\\/HR3PbOJE2nElet4j9X+Cn83kvu2yM\\\\\\\\\\\\\\\/3OmAhzpMu8Ijs8tx10GyjepKdF4cTk3U6snBR5aOxqs3LOnYUo7RgcXVZ29EKNUsRgjnevhqUyTwSjhLex7gIcyHghwKiCVqrJZAylDJl224Yh\\\\\\\\\\\\\\\/lj63iWNL4+k0LTy2V6MdAVilZwVmsCUkezQNqvUg8la4lQr\\\\\\\\\\\\\\\/ehr7MK1KhZlOGng9Wu16p+4urB12ZuifMdjpDKWzhJTfsDRdhWVQSFWyZna88TKSFfOCIBvPlKUbAauP\\\\\\\\\\\\\\\/5jn3YDyRj7KgHHOwV0ZnURONwDtuo9AX6uOF4knm2+RhVilaZGwC2PI+ayUd6PBaJ2Sr0k7TowDiEBeQ7syeZ2p6uxccjtWPG8iLoqREoAX2ualWmtEV7vn92ejL5kgJlZbvBNzFmnZ5aGNV1bLefM1Qcz4BgkvPV9nUDyzt3\\\\\\\\\\\\\\\/u3uJMubfhPGKYwDxycJw4FFdptjFeptKi+fQMgu1U1twaNI08fEkm\\\\\\\\\\\\\\\/edelKvFtRbmvdLftJ1NCVElZfYzIWvbw8xsFPYgWPH19rgZHyaZCIy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/87LmjWYdImf6h3A3qJv4yEQ42xRSPOoUZj\\\\\\\\\\\\\\\/GnaiwbYFWNcI6nOt28vzjQPqJxFaePQKOxFuui2PKLNYsKumGgBS3sQSPPdBzg22retw7z+FBWBl31f2dTgNj4oJWOjFsf\\\\\\\\\\\\\\\/7JlkN4VAepvcIusrrOymXByWHT8SNMNMmEGy9ymvfOw4Rnppcqsd\\\\\\\\\\\\\\\/DPVJh+NfMibrkp53WiEgduD1Wlbbh4d7oZ53VcWSIl+H08+5IGDJbdwZDFY+kJTVoSMCQITy24znkDvFrXlx0TSyNnyC7K\\\\\\\\\\\\\\\/SF1n7vjmAxvuPVabVxFV1\\\\\\\\\\\\\\\/K9TG70DgrGRT69N5ve8agyrfSrEvBr0ycnmZ\\\\\\\\\\\\\\\/RBw3kqMG4iBRu48Zmy8b9pvujyvi1BwKm3p1HUkWLJZT0TjrLwWxCR7YSFRmfKXtv7IixOVW6T7m5ftTnrR1UNmSKTLzm9TT0ZykXjF09AKdDmZ6UKeetv2YSr8gNXGLECPCyOxpAQIQV77xHEocAr0fDkJuVv1lOWc5D807zMHtgaiYmvSclLhex71Kd\\\\\\\\\\\\\\\/6TgaENeNjEJLaWFlqw+YKwhTOZgMpKAReTWXJ2BhMRn4EfukeitfhwPNevdnWZAD2FEzrUrdZ6roTxJdtKObcsaPliLAjOTwkfSfxgSgTINgBVOu9nGPPc2OUiLlDtzFNKiQdEj6k9UBemwP\\\\\\\\\\\\\\\/YZp3X3+WMKPR39en4GzbTwytpGQLBlHqJ8PDjFp3bXMu0JcYCK8gfszCxPI9FaYA0WXDDClHRktfTzCUGZLMDcGqXry9\\\\\\\\\\\\\\\/4vLDUSQ6EKRn4y\\\\\\\\\\\\\\\/IVyqy7X\\\\\\\\\\\\\\\/DG31PRgNzK026IitexMu\\\\\\\\\\\\\\\/8N3Pv9yCxBwvvZD8SyCul1KCjXaQukNuxyTwNZuQaMLF108kKskdLenQf+04Xr3dxMa4hnNj72b5UlQg69o\\\\\\\\\\\\\\\/7AS57MNP4H1JH+HNwN4mrI3wlUhnQOM1whjWfmEbyGe\\\\\\\\\\\\\\\/HwAt2V8t9+z4VE29uVulYkBcACP6uM71MiLqQ1kC2MG5E7Pas97VcO9TVgcA0P9XzjBTCjq9wIMVZU7syfr3RYsPWNFnqShxF\\\\\\\\\\\\\\\/pNSB7rmbsA1EojZybuRR7s3\\\\\\\\\\\\\\\/DUENYk0TvrnHbSDEg7dzOW\\\\\\\\\\\\\\\/h59P+jh55CmV1T6VNB3l7zTBnpud8yeefhaIBTJpNDMm5WheN5l3BoBztcTril3i+nRz5bs6lr8M4nEMXbvWP\\\\\\\\\\\\\\\/hUlf+hv4W1GowrD56F0Lcd7eYz4P9PLY\\\\\\\\\\\\\\\/Wst5fmVa8q\\\\\\\\\\\\\\\/Nbe7gWuyFMMrq7I6k39ulMTfbf8A8DIGXe5B203MKXBH2yV9AMTnYIdT3mkQzGAzlVD4FYy80jvAaYbYeJqSeLoX7h9yD9I\\\\\\\\\\\\\\\/ZTtQtos6+ssgAmQRa8kL+cxcgM25XnJjtRZcPY8X8BI8vBT7Yjbjo8JkBGtuhc8IX2pRFa32XbQMG9hgvxxsT1jUj8mfnnQgwpC6VV7H5IP7yE7JdavUv4KlH8Bp9B\\\\\\\\\\\\\\\/8BObS\\\\\\\\\\\\\\\/blFFRuuEM147IHRfbXZy2HN1jFzAxthKXbuO\\\\\\\\\\\\\\\/SBixhSjvo59jEAetXccV\\\\\\\\\\\\\\\/NtI\\\\\\\\\\\\\\\/zT1+A0LNuaXTLZVtgQmlvT331dxxERtygkW7Q0vwgygImTUqjpjuDDUlGnLDpfSpYdpRtCghoEawnB1wPnnt19vQrOUyWFymgFN7UEdBL2GwbFhqq7alZ1UkG+\\\\\\\\\\\\\\\/RravcA3FoJSoD4XwnM0+sOfhe2s1P9phh1KIpGcW67TvhJmdOvotXfzKB4PsOj\\\\\\\\\\\\\\\/v6tcon5RkcJb56rjfV16XqB0gEHIe+KpnfCXyiLL2UfaomRc+JjliKe9fyLdqG4lNYNWGcTsAhNvobNDtsGJnbaUwv+4o86R84VOXe5IAK0HaJ8CsiFhDVeVJA1kYGnEILEW6nvQyCoAqV8VmSRvr9\\\\\\\\\\\\\\\/QjiTa0lQrLj6tde1IqBFjBtrRmVi7mrL2gxEyrzDel\\\\\\\\\\\\\\\/gLlR48j7Yp8pp4TR0OHKK9nyPPf79Nq\\\\\\\\\\\\\\\/8VtYjl0bV6HEdNSb2XHdlf8u24rTPdeh9o7IhNdlW9jvYDZ1AuhcNpC2c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022fdHOT1qx9GRHj6uNJkHekg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bf59528caf1d8e64bd0ef7d684364175f54a1f210a549ab690fab41ca5c5f633\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e005577corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e005577corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;11\\\/1\\\/e005577corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005577corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005577corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005577corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}