{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022oe0nvIdw\\\\\\\\\\\\\\\/WIeX7y5DX\\\\\\\\\\\\\\\/9gMEVtffzA8\\\\\\\\\\\\\\\/qMh\\\\\\\\\\\\\\\/uM5dDu3hLgu9slZanXkyY6iIVURat5wklrjbCXg9vP3dxWdIlMivWwZNulcTDt2NTC+YlEhTjeOKsSHUduB7wNTclzrx1SSuo1Pn1M2KhXlDcbt+UlZ3XZGhXHu4gZXvVME2t9sTI6Hjos\\\\\\\\\\\\\\\/G4gb9q7ybs6tGC+EFoxnvEEHF\\\\\\\\\\\\\\\/DSLTpkHFpcYxGjzeg5d0ZaRNVmitlkZj2fNa18RTdOs8gH0wbm30pwY\\\\\\\\\\\\\\\/rh5+TpWqTqNcoqN95\\\\\\\\\\\\\\\/AJV+dMl0XdDMALmfNPDPAKIGo\\\\\\\\\\\\\\\/CWZrncjbPY\\\\\\\\\\\\\\\/pruvEQPBrr1KHWdm47Iq5vaIC7Ztvu+4f1qQjzMseSvVVwBDghesVMChlAuctPOJ+XeHr15YLbh\\\\\\\\\\\\\\\/lgHnp\\\\\\\\\\\\\\\/jVXRuag1wAqXH6yzL2Xcw8sFwXyWRHXtfwgO4hZeti4FySlfMR8OGVEPT4xvPnL8BeAqwPsFkqrwh2yspQzTn6aB6pt5VE7TE11144fUy\\\\\\\\\\\\\\\/LM0jwKjmPeh6Rj+oA0bSGFqb+bQMzmglN3lvU5AdJ6NLme4op7iXcEoHO2AMJPmFnumY6eaZUFLgWEMIucL6J59dIMq63+pVowEpEeFTIW4OP4EI9WhS3hQ4AeFxq9OQPq4u0oATm+6P4g2lNLDxddrY4NEEJyNcGXYaOWWMqqdWQ87CEGjEKTS4WcyFV2vJLMlnIJYCdVEILDZV4r4X\\\\\\\\\\\\\\\/hMux4Zx9a4TZSoeXhy+\\\\\\\\\\\\\\\/7z0BJUbj4hk+d7OB9WG\\\\\\\\\\\\\\\/Zpzgr8uBpvychSSG1kojEQSQgNn2Ixn8WuFhEJCOq2aE9hxBfaPVkT5wAqXNNhDqRnSyVRGrGhUxmZUImzrLOVTvqu6NOkVKMgeTgBUjm6pUmFlVHcE9wWFsl\\\\\\\\\\\\\\\/4jakwNWlM1BAfolEj8qDDzPqEY1QFLdpmRsGm3iWBNPg+nTJPrB\\\\\\\\\\\\\\\/wiEq3kxk\\\\\\\\\\\\\\\/a5fYIMHvkKVF7rY76mNij2fr8MUGTriOYNx9lSrm2bVtWTdD4ZBOQhqOZU6VkSmFHMGl14bdyxuOAc6TF+\\\\\\\\\\\\\\\/EBEqj5bQlyqQSQfr5mWVeLWGIzB1+rLaVuCXqUokr0OCLD\\\\\\\\\\\\\\\/obdaecefRQ8EFH6hzrTY+0RQBlr19GiOwE5XVdVl+Qh759\\\\\\\\\\\\\\\/AOeswSNWXvjfOfYFgtoCh7EAC37GXA9ZRQCMC2y7KZp2+2TFSGgybEc9cMPRQJh+xXCRE4xkBph6T2ixIsgDXfe7rxfwYg00FyZ+q7v061njDo9RjF4UxPbPdhw9sJvIIFHhtK100lBjVJb1vgu4D1NNPyw8ZnGDG3YdQzwh0Cn5+RzcK22FALJMytmiigZCbKBaEQ2LFBUl98x1N0GeWPJGvzpEACM1dSLHZzOUX7lehRDiQZzQKCuL1vf4KrcKszghbcbw9aNOF5Z6X0tgJ0zQSwpTHV\\\\\\\\\\\\\\\/WIXn9GPb9jVI2qcBC1qcZy\\\\\\\\\\\\\\\/XsZcQx5eWUo6DJl1Rfc+K\\\\\\\\\\\\\\\/u5kXhufCWrOkenOJnneqthtJWuEyZhPg29svi5Z7ofc7\\\\\\\\\\\\\\\/v9eejg8bwe+KhNdbaB1QVnOJqCIJvxAtY8zvTqYWnATDJOHwKDJ5L8AhDsj+r05M97VJhmY65oyx+mv4t1hGjixFrjUqHTMYEuPig7P2FQTRgGhsQAT0l1UqKSInlt5iXZOX5yx6AMdWG4XeQOsEGnJRa3Gm3V6R\\\\\\\\\\\\\\\/0Ytg5+PDZXel9iuZ28CWFJ0brwwt6zms1S+AmEN\\\\\\\\\\\\\\\/YYfBAuiqhVrj7NL+hFoe5ELfiv9AzS3QKAnjOaR0sJ3qc4F3\\\\\\\\\\\\\\\/UCqA7TwzuJ2crbcsmuGKSmgCDlEV0pDY5txx66hcLqEdjBvnYUe7kOMfjRWiifNinlChJkFTS7nxl2L+qWBncRDg2zMfwtYmlJZsTvPRg7IS3c+336cjZclv7voVPxSlgUYFJPdgeIQmXu1clih82OFpcYTjAPAfK4XN6aVfWyQokmkcfii+9n9FWEiLXjKZ1Da8C4Ty97h6rkmsWTAwO3Gw1BHJbTxUzziT8XdE3HPiXpyiVdAq1FOHE+dxd\\\\\\\\\\\\\\\/hTDLLa34AItXRw9sKkjYKvgk6Qopgp9eKelQqpVE\\\\\\\\\\\\\\\/JQ\\\\\\\\\\\\\\\/ZqoUFcKZlpci2z0USzRmalWnjAmjKXGHcciGi73b\\\\\\\\\\\\\\\/kOgBD0F8Oyr\\\\\\\\\\\\\\\/OsgtZ4IU\\\\\\\\\\\\\\\/7j28eI42YnBGWu0AYBiTtUdbMw\\\\\\\\\\\\\\\/RMnn8WZgndiQ+noLynj6YeuoiNWSGUgiaZAm9+cjeLXguqakgpd64eNP2j9oZaSiPWRPidoGT9vbbnCxXCPOkQhS8oncIMTKN5GFDnbJ0aP9Ah09ZfrGZ9JBgeNorl1SZ2V1cjRRAYMHn6hckszNQj7pV5lXsUtCG\\\\\\\\\\\\\\\/lMjqm3u8SWGea4uMTwJI\\\\\\\\\\\\\\\/542fkPFaHfbRROmPWwBwsMdNJqOUf5so6gBMIisOAZJNFYoJGgPgYRrqmlSEG6KTIMSIgKMJlj0z0dmlpE5QTcXVQu6i6mDWKhpoqA0cuJHbuw9fnlC4z89N1kRaBPuB\\\\\\\\\\\\\\\/Fy2Nrpok1cPeqWbcZa7Rkx9n4\\\\\\\\\\\\\\\/BYNJ+x8XJ8A\\\\\\\\\\\\\\\/qUxtluGYIDJ8julNLzTANo5Z4rTgDgbl2to0s3kGJL0NoNJGQN88+W6L9z1an9N4i7OPi\\\\\\\\\\\\\\\/NIR76riw0nlarI5ETMYl6y0pzEV2d8fWGs9g1nQGPWhGH0Ccct2JU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022TjmPWbz2jxe5cQmKheqzxQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220c6cc7c517a2c61e3608244f7858a52fd9fa6fffacb5de872e60c797cb1ce9ae\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e006059.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e006059.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006059\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006059\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006059\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}