{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bWZ6n737Fphh\\\\\\\\\\\\\\\/FKPwtvE4UyJ+hY+TWOUYJ3GFoULqVqEvqRcvQsG1dVLNc+ST2PUarW9j8+bsOr4Bp1paOzNt55Y1lFsn\\\\\\\\\\\\\\\/2NauHwfQw6lGJAqbk9jpdQK1PWK1ipRWOoRXsQMYYYCLIDh+cOs87xIONA7L4RHNL7fG5mQVXq2fFVFD45\\\\\\\\\\\\\\\/LYWX+AM23bGCPwqb0ne2p4hpx8HaPT7UNgsb7IS97zVfQT+7b72ySW+8Jq6TIWgG5xjI9yQeWjvEjYRLr66c7rEig\\\\\\\\\\\\\\\/2aj253mw5JVWRgsplV8qm9ndbm2O\\\\\\\\\\\\\\\/SunUhMbUQtoeGJQjjm0GXlAFVHCpbjH5\\\\\\\\\\\\\\\/5gGzXReiDEZ6VALF9Tt0bS4Zi1p58F+2lpAmQ\\\\\\\\\\\\\\\/l5V9FRmAOZJlmGZCU8DMCbU2fJxKIHy6buM84W11D9HbBa+wNFUh1Tqr\\\\\\\\\\\\\\\/CyFhqBwx8PFf1C6N7KZCaVpxWj5KIV\\\\\\\\\\\\\\\/4BzFjQgixaf1qpaDHbIYjnztOCZMNQxOkRs1ktExSPdegYL616Ihx4ISHCQwUzeBDyWiffE6k\\\\\\\\\\\\\\\/oz5yg3ic5U6CnlK5D2E5GjXhyPhedfLwbWBGTHUSFPaDMQjFsCU98v\\\\\\\\\\\\\\\/066tbrcjtbCqBHZwonijR15+EzjPOR6UBQ7LCtiOGueH2vnZzuGNiXT9EOgYJy+hrXJSAy2Jkixvh5xnIDSqNqmS523SdlXsgXET4pq5frSn8eHNJs+nVb978xUnHVwW2NTtrmpEgFvhHr\\\\\\\\\\\\\\\/jIaziFz+aAVT6MHRolpBGr\\\\\\\\\\\\\\\/KzKlLlm6pigNF5d7+f0ea1Wjc6ipW95c6PmN\\\\\\\\\\\\\\\/QKWhx0kliIWQRHIFvgSJOhX+\\\\\\\\\\\\\\\/vt88LeaNPLw9NpfUi0sriEQVPYTbusoliOWfutoKJyx1ag1lbv31u4VO0HGje0W7jw5aG7KjGopVftGg1aR5ExUuMfvWaAmedq7jhDYr4CYbtLyYTRJuzG8JbOakG2zLkwbxrXC0xnfOz3P15zzmG57DfhpuiYJ8TpVjTdb30ZvzZL\\\\\\\\\\\\\\\/egsobo3yGZiHSseVCELd19USt7jw22Uo\\\\\\\\\\\\\\\/3nDO1rMZiXyg1UtBvwLxH1zVXn7BYa21I4iI\\\\\\\\\\\\\\\/7ywzmZZQFnI\\\\\\\\\\\\\\\/2iz1qxWBp7Hi+fKYU\\\\\\\\\\\\\\\/MlSCFBXt4ix+xbXPdIQQ\\\\\\\\\\\\\\\/E5pzFC7NcKLmHWqa6z4zkK5pf3+8bhRztsc1awQrBDQ0mzOFZaalxmu2OsE+ECDOb6vo4RqK6RfnZTw3tDooPjnHvsMy5dor13m2TMt3AfopwCcBauM8aqqKQXZ2ejlvOvN4OknsNOGudqtgOL\\\\\\\\\\\\\\\/U6+TjQkZdoMm8cmmiByRFcKuS2t5PaMZ26VPM\\\\\\\\\\\\\\\/RH1smpiu2QkXFET4vI08jctqL0GDj2qKlYhZHr5PTWQ5\\\\\\\\\\\\\\\/YVJHgr0fAXsVq51JBN33Wlr+8OMV6QVyn4mzNx0kQRkFzcOOmpdEHc3jtg2f3HM1E+Y6XOsmn1r8kuyAthunXhWM+RBQBGHY0+hf4\\\\\\\\\\\\\\\/odVb6lecP8n36GMqM9ycBzC9JAtGDz88Pz790WgfDHlqqOrwFnlOBB2M+Lk5dfhrQzuWboJlvwDx7e3\\\\\\\\\\\\\\\/DSNMI3pziXshbB2SC3S8\\\\\\\\\\\\\\\/9ZL4HB\\\\\\\\\\\\\\\/VpWtIaksQ2ZNWVBsvhTANtNqJeWLRMwvwzAAdElAJg6gEP71yQfReCc70eNcQaAML1OlBbHHlscunDdECyNsWjofBDfc95eyPt59HywSmCokJw6y4nzqsC1Eag29btm6oj\\\\\\\\\\\\\\\/pUZZISB7+7pqHGa3IbAs9hV0sTHoZj7RLLZh8Z2vHAk0fZclm19yhGMlA7ykDK8DJTVlzRdAgegFKDT6lC+u0yCA2W99htYH1NcW6fBwedN\\\\\\\\\\\\\\\/Kioq\\\\\\\\\\\\\\\/jNXHTJ6pOFHJuXoJXbMOS8RD5zfnlCarEYeQYpXOTpLLl7h3K4cGzC3dIL\\\\\\\\\\\\\\\/CSyTBxSopcJgidQ2BY6+14TmVn2VKIHpk6TI0w+NYyR7GVHa5E4anawGU+1svGkhummCMTOR7fSiQwZ1\\\\\\\\\\\\\\\/IIN\\\\\\\\\\\\\\\/hxR1IyW9LVfm435+UUDjSELnOE48vMdO6pJPNrCuTWJ3c1fSrk\\\\\\\\\\\\\\\/dGSgRVrLrz9v6Aie8oHmxSrl4GVThcNOHSjRffOivPuZrv83dqIzHuV8yZ0vuWVD1dVyYev64MGiI49LNnd6pRkrGX1qu4gPQ7NvWXRAXX8lUWkI9lufkGcsS98SxqswFSfXOjM8B7K1KYFjZV4LhIfrJVsyV1i+4xqiCgSrE+x6BCHOcPmamdBCEcn\\\\\\\\\\\\\\\/OkZufddYSLKPIQ5gyBFx\\\\\\\\\\\\\\\/oBQwpMHnWgdljyv\\\\\\\\\\\\\\\/ns2\\\\\\\\\\\\\\\/yyO1sfIfGujht+72EUuMHBP1\\\\\\\\\\\\\\\/7I+uEokS88RQd8tH4gSVE450zFkjaLbwjAc21ad0\\\\\\\\\\\\\\\/mkYfMuS\\\\\\\\\\\\\\\/YpujLoFP3FT1Ohz\\\\\\\\\\\\\\\/G0nrtc8P\\\\\\\\\\\\\\\/3M6Uzv6ee13C4z+cdNiiAkbsYHbX+v3T2nENL1krddjADDmQeo0iUPgQE3G1NSFkIXIP3ts1H+pf8zJ\\\\\\\\\\\\\\\/ynfDW6KI55ja8LwkUJtmpnZ1fln\\\\\\\\\\\\\\\/upcY8uu0zcRpr7z2XiqU5cXWUKZ1VudtjygldOkJyDadochIyklB42ivqk6eiTIEnQLNNkuMFBY3jZLrFer8iQMYM60QAgwUXrvzCsuevk+Sj8oyaF2ca8JASm4cgS0PX\\\\\\\\\\\\\\\/gliqLi+fn40tOhdaD7sSGNk6eA0gVCTOdSZ7oLS+K\\\\\\\\\\\\\\\/g2+lAqoc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XZaoZwSGPT80Mwl79E6Msg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f40cae2e32ff7afeddf4a359057394d1cab9d7724171b0e473f1f16069512b71\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e005007.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e005007.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005007\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005007\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005007\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}