{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022wqn9CA0CqeS\\\\\\\\\\\\\\\/plclJrb+yw9XALUjLLsOWl\\\\\\\\\\\\\\\/ZI4UL5s8W+OjiX6+aRhGTTmrME\\\\\\\\\\\\\\\/ON8mdp0IThw4m9sl1Vyj+Fs4g4jVE500P1M5SuOpDhdLx09m0roQO8mYroi06Yqh\\\\\\\\\\\\\\\/Qh+sB39c1YlxakL4+aELAYUAXo2Tj2DpoMx++g+eioCxmgzuYwMRrYMtP0tvGX84hUfTb3ZE9ha9bsjgVCovEuYhjJ\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/b8rTtgjJ55Qi2Hjq500mhQMi8l4LW0ZsMohjrOXFpuM63D66lG08GmU8UxvFQf7cKs6Rkkcgv9wyrz+18yYNgrIggOGlhkKbKpD2ZV\\\\\\\\\\\\\\\/3C2wv4DQWMeAPZjWReO2F0GcfwRMGTshXtK+aNddvSERGL2A46U64CGdnXQNpnqrGGtUh4hOQUTOK4mVxIqHy\\\\\\\\\\\\\\\/f88fzOl00IQk5zCFlMSOGCOgvRyDKfewEfrI7A+voMC4OaBFB9H1GRKEtJWScrVAN502pMtMl50ME0CWmSlGoNKIqDS7sKgW1epaJ8DVnmW8VW1mxkhBipeMdYuoTtjRtBp7cobTCGq8xJD\\\\\\\\\\\\\\\/zDK4HOtspq2j17wQbj0pUIFWOyRg3+13X6rOQ2OJiG1GCnbXvlGpAkRIT36PDcUdSeE0c93mg65M52UxNSlItDwC\\\\\\\\\\\\\\\/Vgh7RQSsGBhar8ONng3AH4+COQWpV\\\\\\\\\\\\\\\/qEAtdl57u5Z1+to0Z2BWBWotFjSgj1PEACQbFV\\\\\\\\\\\\\\\/TZuY8AxQ+7YpcOgfP7Ldh8rk9us2fTgW5IkMBym6uiEXbqyt8MdpO5Cbi0kAK\\\\\\\\\\\\\\\/ks9KF56mas5jA5I0WyTlRBv63KMCpbBHmCPuUpdW\\\\\\\\\\\\\\\/zrhsRuY+pCYEvTwM\\\\\\\\\\\\\\\/scUCWnADpzRfT1PiR1eg10lt90tplPxv6Yv9Pnp26WZCSCoG9nZefC49bb1Rt3DtZys51YTtvOQSfiP8bFr\\\\\\\\\\\\\\\/U1d7gSJhfX1P+t+AP+pauQGsq\\\\\\\\\\\\\\\/+sJtp9pelJyVLQI5q+1aQ8X9KTOVpfvICvFG+VwJyJjQSG+YNwnFz3elwlah3aSHPNYj5Kjt05rDyQf6Zmef6QlozEhrK9+J5pBfeaZQfxr8MB8n4dAMBn3JrixKzR5q+Lp\\\\\\\\\\\\\\\/grMl+b+B73cGpG2nZpfmjo9D4uGEDkM6kz4aLVxM4fAIC0+qo3q9h0yfwsVIgQ457T4UCvDxwBaefjMBPrI2NJorCWrYU56Gq8rXR04EnjJZ29xBRYf7BFqeCv2S31\\\\\\\\\\\\\\\/E\\\\\\\\\\\\\\\/Y31vOiPkmELQdNtJpAIWOEaWK7XiZHHmO6i3Z846\\\\\\\\\\\\\\\/81s7QLeK27vdY+ZN\\\\\\\\\\\\\\\/bjHZFC7Tbtp2sM9b8b118yDLCYTKAJhWfQBSI5bDFgZHZtXw8o29LPTDijjiUPgTaTvSsSjyf2o\\\\\\\\\\\\\\\/FL5wM1lGE06GvPAx7+3Id1yS7ZUlTXhVmaVibS\\\\\\\\\\\\\\\/OMu9yF6ATA6JE3FeVYtMgZAX64d5v6n5g6uKSATQ9Gys+3VGXaHxcAiwkzMWkmDagtFe2dZkK\\\\\\\\\\\\\\\/gyye51X2eDBPGoAOJ2uHAqWlQF4ShGo8LuYF5Xglbk\\\\\\\\\\\\\\\/hdRFtvy3xdBWWQTzd1pCRWUK3\\\\\\\\\\\\\\\/aPJFLhhwRvrHih3kdX22ZcdB\\\\\\\\\\\\\\\/RvtM983BqA2HPsJ97DVLSq6HjAoknIMDOk5VeQ9oNu5YIqv3Xgkrme0dCrJVjcCWFQAMrwCM\\\\\\\\\\\\\\\/yCxkBYu2iqq\\\\\\\\\\\\\\\/8\\\\\\\\\\\\\\\/D56kIeLnNklMQRmw3YbDTIkDoB3RzjDFJX7I6Yl5GvBW0WIFSofDS+jUW28YEuj70ASbaObbE4cxg7Ijp4wiziz95JLXs3LNTnokikeF3SCHyVPN5LGt+D3OKf2kqTwmkuVHJyLBeQpB0oX7LXPhDXXX25I7GYX72s34yQrBKnCTgNsZsGKI6B0ejoboUQbMp0Fx9YxhpoQcLW\\\\\\\\\\\\\\\/rFCdTYepj00FXYdBgr0lhP9BH9iEKZMWj\\\\\\\\\\\\\\\/9Exv8QwMaFECWZRlvHGDID7Yfm9si+ufn6ifHyF2aAS1fpsXkD2q37wVJ6p7qH1ajrM+zUBvZ3xfgvkE8LGh5HdsxfPUJRZtEEbaTGZYTba3Lmp1DV+96uyaVj5uWWL9Chs0zG6TspVlT9jQOyIKyJORsOpK0uQ6kS1zcKapDot6VBgSHyxJg7QRp4ZQrP2rTR2zZe3lYcLG\\\\\\\\\\\\\\\/JL\\\\\\\\\\\\\\\/7+0riVevrcmpmwxHj\\\\\\\\\\\\\\\/ZwZyisoNPcHQzCbOPOHU+OpxEz8qoARh8BCps8CG2n+XyDhLYXKcZ2PtX46yQFfCuOJWYzA1h6tLalY\\\\\\\\\\\\\\\/Py+Jql2cBopkfdJuRr7YPIZSibeHwKrOmwmEfo8qajwKsWPsE\\\\\\\\\\\\\\\/N1090LGuqvE\\\\\\\\\\\\\\\/sic9JjULH\\\\\\\\\\\\\\\/8t\\\\\\\\\\\\\\\/pRjcvnYana4telWT+0Ds473c51YP4XV6fQC3USDZoECrsVGw3pW8oP4cD4BT1ToFx7AMcoH5ulV0tcA7pAVypdyPGgyRonyuCg\\\\\\\\\\\\\\\/z6MgMEDrh61oubivmsuO+ne15dAhrmCBl9gmMJcug1tl1GLBEmM1oIz9ry9oQLiuzAqCjLuNmJZd3fEhkURFxrCBTR3qk0H5m16Rbq37DToMxnvgSvbB8zhe7xAFpeBpVAcC3SzrBpFfYkixZ0wlx8AK5tN7wCw1FI00KZxdqEkmP+9SbnGG76iqgf2X\\\\\\\\\\\\\\\/91EQJ+ome97zmtf5Ku06fneiPlY1Shn2CM9Asw4zpBinAtGWuQZI95ViGpBBPqc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MK1qoQCseF4s+FTXmB3o3g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022561a87537c5b6a445f301c3720a1652ef2f893d65c4f82d3d936a987045e8dd6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e005592.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e005592.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005592\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005592\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005592\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}