{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HvkhbXne+xDwtqQKvwRAlyiCOwvMtYJRE0SnOcQHO7CuT5wNv6abAL6dkGRrN8AqoTwlVWMMe5QlEih6fF95xzYH+F+XpBFHvYbyiAB8rY1FAvY7kdHTSUc4IzAfBYnD7vSbtxA9AD5NpdTm84RfC588\\\\\\\\\\\\\\\/3LuFQRZvUGs2aePqX5PuBx+W4BPVg8dC\\\\\\\\\\\\\\\/MWBGvYn9PDx6SPTkbz53mgbA72K59kkPVQWsOkbGUbJRxfNcDY25LuE\\\\\\\\\\\\\\\/eDPHv+GicP\\\\\\\\\\\\\\\/WdNKrEWBnaOh9HQ2V3kgrCBqDxkcNXU1y4619IXwu5DJVQpXElq\\\\\\\\\\\\\\\/4J5I5vJmHHXmDKaRk3QTWkIlLoc7tiFIDluxxsRUaQhTW8KcUR3h1AIQS7ThNrS5sb4FNEvl2LYLJNeqCGLTvBfDJh2x4+OJNoRJ18zVIUBOYyfa0HFFKrx5RWNFxwsp\\\\\\\\\\\\\\\/Cut+D3JA\\\\\\\\\\\\\\\/zZvhPPtd1fn1jqdptCgmUOgT8ylIWoSr+R5BRNP1RjAMu7ZTZhNfGKUX97Hy3lRubGj+lPdxcM8rB6WJTG75Hzrub+VjYmbPUAPNTKNAH3fzi8+4jcVEjJGcfjIvcF+QF+g3m2FVLGXVCvmlaUBJT4sAUfGTDi1xmM85yG8wLLc+A29EoVJbrjcnWGAq4QdUuZv0lLpLinw7R\\\\\\\\\\\\\\\/cUC4LcV1ghgAeRW5FwqbffBePpi3xH+yoBroplgrymqfc8XiQfQbb+dRKIRXi7bc0PS4lwPTlvxHCt\\\\\\\\\\\\\\\/1l4FvlY9A6vwK0PhOe5Ts0Gbpr16oQenkK9b1qwb2gptkJ4jHsITDkARNDU5mmJRbsganBuWUDYFmZaydWxXYfcYUwDV74Qb3PJ7DYzAihVl71JxobzpCQiRevu77kfdtsvof5e3SBZv+c0FZPHI6sS0irMkvwDC+dXFvDZi9AqPdoLMjQMQd\\\\\\\\\\\\\\\/w28JrNgzsnLhUZgw5H86aRbrCRR5zUvYyc7PPfTdHKeKP8eEhcvZATRy5ngMxm4ar1CISjzCBoEnfzw4xfZ3wf1cy9nbzw\\\\\\\\\\\\\\\/Jrm7HfrjDmJO+BlG4dTPFBhaA3NyY7xO1pJSpF6hcyiUW7F+6aczI2Xz9B7SeWUMzaxemp8Vsj2\\\\\\\\\\\\\\\/bXfVNFtAZPuWjCKJgVNGoYHbwICk5FrIBPupRcxmZinc62QKS0iRdy41hpJ5yOQrbZpnTE45R6NU8NDwpjgUBopbnvP2\\\\\\\\\\\\\\\/15vJLm8j9UylqyhcB6H1kIsGLF7MVvZ\\\\\\\\\\\\\\\/AGAjpysmsEONamljTvU3cuMNvtuIhiP6mKABRDO7fJ0969V\\\\\\\\\\\\\\\/yvsRAi1SBhOw53kshLMmsGjEeAmsaaa2\\\\\\\\\\\\\\\/YTLcBUkPIR9bEXIaZCqHadyzLoOnGzD4O1skWCcSPW156EGmuDeIvyEmUJm3edBGFKa0EZJXEL2+tXGcfaRzQ+H9p7IiXVfUAp1icp36NqEkaDdyiGD4zeGS7cVIf3ZT7Volhh\\\\\\\\\\\\\\\/8hZPsbEtrHl\\\\\\\\\\\\\\\/NoDayj9rPllo9iRGL09AYWDdQ2V9gJmTLljpSmHR6LYjYImtjrKz33Oc4R5I9AxWH30qvjS7HN90kM0yofghZ4MB7a1OLHp57LqE3nKYr2jzc7rPnxyE4rRwhwZGhkNw\\\\\\\\\\\\\\\/20aE05po7V1QSnag0Dxcrd\\\\\\\\\\\\\\\/uJUX4dyr\\\\\\\\\\\\\\\/HwMRhRddSSgkmSL\\\\\\\\\\\\\\\/ylw7PAWflzuBmG4PvKcFLASoPJYwFhcNGCEBHoRL68p23BiA5kApSV9a2E9tpVMQ3IYSaYIzUrZaBtjATcWfR+FTHK6l4rmDJhZUk8hSOsSaMWuqhzTaZF1ENdwlpepevyjnu7\\\\\\\\\\\\\\\/x5YkxYyGq4CgM8QlblR6YAN2saCi\\\\\\\\\\\\\\\/XJq1UMb4wJJnBizT+j+Z6D32sNpzZvOM7P+xQud1hb8deOxqoIfhWZzWkgQWbRG5pkmA0+5d8GMaqnxQmWGTjsMjrsYR3nfXpGYsLtC\\\\\\\\\\\\\\\/FSZDW\\\\\\\\\\\\\\\/nYVsCIbfxV1q5mVXOAAR9AqH1Iw++8AVfZvIvIERrhtTqCy2r4UQ2NTkegpCPqwijLy4PGGgJT+z5Zl00+VB6DXtsz2TPB1Sd5ns00tsukIEQIyuH16ndXQcsHn0UUI2bNVVK7Zb57FfS\\\\\\\\\\\\\\\/Z2ujm0kpQ0tQBDg8ytSXXaK3lvWQQsAhPICIogMO5Fu2+mcrzpdOX4YlPUtAtkM7SFtJjg8QJ\\\\\\\\\\\\\\\/DY09v940vt7Ukm3mh+yn4TUv34PEYJlL5trDOZ3oo\\\\\\\\\\\\\\\/M1ujSzzFlOXa3wsFoOWjEAsZBp4zdLj8OMAjNVS9YKHuSKcL4siWEzETPsKaVccPJJOJu74JyUSJVqqVlA+yY\\\\\\\\\\\\\\\/sYhrVdyd0GYVqVtYR8PVHfri+OCqGXfBpml3RSDgpIXpCUtXIpy35WxuINNaPS80qL6z7WNxwUO\\\\\\\\\\\\\\\/Usfq9GpwV3QYKcd6D7Q8oVgrBcqw7OXU+zWcGI3w5c8bH15sy+PKo8LvDhzkg8uVSiIM6WdopxoH95jcwfDhS2mbILVIVPfVzMhSewHEgdgpTiy6fuc6YwdwyI1C5bR5X9KXlbP9oY7Eu+JXsYb54lF11Lnewj\\\\\\\\\\\\\\\/qG2sxUW+5I7\\\\\\\\\\\\\\\/Pzmmi7msVWxKRl9Vr2O+Tz0FjNR2VV7sGGy5uDhBQjuDEFXudbMcbb8S29Sl5VynLt1MuWvuNyMLyGzrbdWerz1mbxLHoUoPeKySb7C9cdeaVxjWNMt24I33d5Rqsig=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022sstpPRmjNAdItgf+u87IDw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ab8b32701e1053f85cbf11cf1221487f1305b6ec14ff4546bcb084a052e614c9\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e005425.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e005425.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005425\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005425\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005425\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}