{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fN8ZJiCcf9VGvmOSsTmj4CM7qP8oVVpz9Fx6wUk0c3ERLZhPuso5JkPpGRmr3qepEJwkUr1bgG0OUHwThGq2R1O4vIRV+oxaMNg302pjjSlE91FFxTC5VTEtA\\\\\\\\\\\\\\\/E+KfC9M2BJfG\\\\\\\\\\\\\\\/s4bnpul7t8PLpPPabAyKmFFfUJxCBCDIk\\\\\\\\\\\\\\\/rC\\\\\\\\\\\\\\\/kEHKWty6\\\\\\\\\\\\\\\/1sVqtljlp\\\\\\\\\\\\\\\/q0Qr4RW+Yr\\\\\\\\\\\\\\\/Th9VIH\\\\\\\\\\\\\\\/9PbYXrh5R0E+Rd1GXBZwOXVkom7CVUAiC\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/AhCFXGQCB3if\\\\\\\\\\\\\\\/jlKx8tLEHy0kSrZRqDmk9nh7CGLJ6MQnCf1962AxKRye1S+tJIYnEkECqKwbbQ7kgFZ1Nku2FMN7PT4Bl+l1IsfHiZTPqaFckHSbVB37eBV62UvtXt4LHf5h3XaW2wY7vVzgaZGSTfV89cjcFSfjELP\\\\\\\\\\\\\\\/v36u9c0ZHQgZlL21dM15dCx2rcOzaXZN0Svb4IU4GDtXFoVZ+Hk\\\\\\\\\\\\\\\/rpxMzsa74D1A5lZWHRIljYrqivgJvZETsmssy+bZC8aZE5+P58jQM6BQ\\\\\\\\\\\\\\\/oNc\\\\\\\\\\\\\\\/IwK3T2xPxZ\\\\\\\\\\\\\\\/kpX5fv2hc3\\\\\\\\\\\\\\\/PnLMU6h8r8woHdVEYZsV+vcgEJ8vM4nJ2etm+q0DzkOuhCR2BDL+5HQDfSaPwrgLfFNBzHLodDpSzTh+p92V2d1lOZ7\\\\\\\\\\\\\\\/xDnYYWxfY08DAp2Fn9YsVHUKSJu8DmlxjPU3HGmUEdB5gJEKM3sh0RCIp\\\\\\\\\\\\\\\/u4GPGO1g5FyKsXmvQtavHVeBDbZUKOHPpa\\\\\\\\\\\\\\\/ldJa6P25HUQZ9km1UxUnUahla9FUz6sxotCK3geLMrTFno3x8HN3qmtVUwBFgTAAxmStjcGbrcs9yhIp41M5C4kQQJ1BSS+BYxEeq1a+501lFf8RX83EMVLSU5dCHaPlUbZz\\\\\\\\\\\\\\\/I\\\\\\\\\\\\\\\/rw7sie4IWgReftoXbprfv7t0KTA82QxG0PWGpGgTny\\\\\\\\\\\\\\\/e3tA2JBnYUPw1h8YOyw7qMJYrwz3JZ14+3VCkV7tPmmIwhtANYQ6n9VPuNl4L2nCAiZcsxR7n6hnj2EQ59xzkPlnYUYR9cmci6BlnlXWa0LEJk4rDEPVb04RV3kUnIqs6Cd2U6EL1BCqRKAsw9pSwzCQAni457OOiFuD1J\\\\\\\\\\\\\\\/KpmEn\\\\\\\\\\\\\\\/1lLSBCDrE8ZTnqS3jOaPtc2Chj805Puya2gi5CmqhFFwSBRJjzEnGqzpUkiE+18BkJ93INfDiJ\\\\\\\\\\\\\\\/cdlPciJvOse3pUr73Dhukj\\\\\\\\\\\\\\\/5fHa6vLvA0AMLIJWuZ+Zhyl9VDTidK62JYK8BZA2aOYe2jn7O5haP+49KCQwqgAUctE2ZewDuzmkeQOciIx+CHJXHsFyiKTjDI1ETqySlyXyR9\\\\\\\\\\\\\\\/1XSdGau3sA0KBkbV9p7P4YvluuNUc7\\\\\\\\\\\\\\\/8RjhZPvDt\\\\\\\\\\\\\\\/bdl4kkM1aAuyiWstDrEQ1wgc\\\\\\\\\\\\\\\/V1FULG1iT8j+dJ40Hv4z\\\\\\\\\\\\\\\/7NVJG8D9eokwiTDg8WR7vBwUW4P1xCOs8Ilpdob4eGGEIrogSd2bGTww2gmv6aAnnOIm19JnjflbryuQ4miaPg7jKzmfstjKtXUPnLCyJZ51gWym74J261MsNtTZw6fg+pIIglBBYy6KHd9tqEUS7fyQ4pRWlhUrX7QxQoMG2Ua9w2MwVTGdqZvFg+P6wa5vmE\\\\\\\\\\\\\\\/oMUiYjA1sptPWg0N2TWf0c319d12o2zQHzsPC4h8dyTwAcYkFa7nw1YiDS9aL9GHbDxc0zD1Cm81VwK+uPt96t02N+l4TiMMJIFNIo\\\\\\\\\\\\\\\/KtNXCfUJQHrvQfLKGwVsGt3ccFALsyTJVIyRG1NRnpcU97NXqFYM9SRScDt+Qs2ySd+l7kWjb04x9ZxJZ6dae5jZzQM8lHjkiivB\\\\\\\\\\\\\\\/yltBuahakqFObO2PInkPc4LvwffvVY7aej54fwi6rnm3BljS53OKDxUEnzyijvfiQ5uinn8KKTPPWfk32qDYkRAxpAS+gdZYPUzch\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/0EJG5B2b5bLQZmQX3tNx0IRVlFlqoBG1pZeJlMkUMSD4ir8xEAzWXRMWv3e4p3ylOOjtfbQL9Gha1IvkzZEPRN9vlav9YE9tR9LbZ8U5qxXJyn7lgnCpKoT0N2iCR7hoKg93YRHUKJJdl3JQg433eu\\\\\\\\\\\\\\\/BXApmt4039mW65Nb2ibsrdrV1yP7XUzNtyzs0OjN7m6\\\\\\\\\\\\\\\/3wXmaMv0UOGLZw5P48m1w4oaExSKdR6b5XeYngLVhjIJAaMjN99fmBjbnjou2Z6F0A7wpNzbzlUaflFNuMWaKozREfizbDTxcFBdap8MWgQW1XgLo33OcHm6VWY9Y1jILJNy9P5HENkBVmYDjKjl98DN0gcPqHoSXyMtr1dDBgDmO6Bej4\\\\\\\\\\\\\\\/JM5S2QqwN3hPU4jRqBoIbcG4kyI5A4HHMTj49hjH2HlyyF02bn2GAb114NU\\\\\\\\\\\\\\\/nBzlTjuRZ\\\\\\\\\\\\\\\/MNDnWBYz5G13xXK6XBzi0qR7yDAprp62dvpg2su3GM3f0xZfG\\\\\\\\\\\\\\\/ughZ2JGInzsqyvNMTUQoDJamDd9DgagC6EdFAaQCxMrsH9nO89gcoSw7NlmGrm01I7XJa2z9uDMSsTizRLfSv1Hjh6t580TlM6nKFtgLBemEuJ4N\\\\\\\\\\\\\\\/Yo5vI6ry5VL+HREhvjj6Twe3klRHKIIL2vpt20np0oUfNuusmZzS+EVd4DDyEvrBDvu+jkJELhaR6M68U6gZWyK8RAX5ERReCfxlkSE9qR6LnTphTh8xco=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022L3\\\\\\\\\\\\\\\/Cq+UYB0f5XkU0Mkg8nA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220f0b1a14076ad7d11d0abdfa2f3ef5964b3043063d4ad3d4535564183db28992\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/11\\\/1\\\/e005425.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/11\\\/1\\\/e005425.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005425\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005425\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005425\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}