{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00223qhaWiAOhtN0PeTdwZ4Y8o4yIGcgibU\\\\\\\\\\\\\\\/Fb+Qus3+cMkUmX4D3UU3WEpcYdgZHDhqdNqvy21U5PzGyshcONw8HoXzc6mSlYSojVYgXwNXVU\\\\\\\\\\\\\\\/BITgjoU16zY\\\\\\\\\\\\\\\/KKZMH563CpBDUMpEYFvJJ+RBAzM14lc1kTOTzNl\\\\\\\\\\\\\\\/nNg\\\\\\\\\\\\\\\/MjDNqUfLx5hUaWMBLAkUucjAGFpDBq\\\\\\\\\\\\\\\/cWzxfZ9FD1Q6iaJmLHuJ5AHbuheUYBKzQT4skmVvtxJw19jt0eYioxeTpNh5oz1FdVhX8xH1Iu4hmz9E+4+AjWuXdA52AJmzV0yGv8TI176xa8W+ZAfXD1A1xu7XDQMd6oZAsa7dKKJ\\\\\\\\\\\\\\\/GinFZHB\\\\\\\\\\\\\\\/1qsFummGwagrvufFYBBQ6bVjTUXUSjcdIt19Pzwcol0yKHEkLd2\\\\\\\\\\\\\\\/RAhvOMUXuJ5xy8FwKLLZJh1lQYSeFhqMSiHeVhFI6j47itSpVgdw13gn44QL+rQfd1\\\\\\\\\\\\\\\/6T3Omsr5dJsS8FXETAqtgBkTrq8wl9TlZBGUGqYDqyJKE9YAYM6msCOR0mfpCAIh8qpEDWwmPDPGAx\\\\\\\\\\\\\\\/GKEvgh3RTwOBxqqMhYkfmggfPhGRf3SDkKgpQQZCwNlljJyzoe\\\\\\\\\\\\\\\/t8kGjX16XvhIq3MAp3lA1x\\\\\\\\\\\\\\\/uffMOjbb1gQfK0eALvo70Jes2uLvncs6eipWvUr97jDle\\\\\\\\\\\\\\\/GJwFgSUyaZ1+MCe\\\\\\\\\\\\\\\/JTznF3ydnjtMM3yUuSXSuNcKS3kshcHXrF0RVX9Pwb72NVe5SQaTYNPFi0FKl7PzTIgcHG6QNpgxoZhWtZmbeR1NG+bc8S9cHZWTV8YjxI3EvcVTrKSiyh0G7cN0Y82QN368MYqF5bA6u5eNlm4YQTxVjt4xjRy7A6uDz1maPYu2dJVm+gMUTGFsKqWb4\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OACjCE7ZSXbZydb\\\\\\\\\\\\\\\/zJHYUxlyFbBB2dFZE+bJbDt4DSA0tJt6IyazdGrNLJyw6JJHwTbc85u4o5baRFzZ+uJhp3sX2nd4dH\\\\\\\\\\\\\\\/5h4sOZ0QWRW7MMNTQbxXq80786xiuwY7o1EAQz3kmqmk0PvE6HwSAHq4Y4QsEGJPgQ\\\\\\\\\\\\\\\/xn8JemrGxaapVlZoQedVweWtMz9V4WI+vzdi5Nyyh\\\\\\\\\\\\\\\/cNGH9qFu2QjWXBp+ANyfwrjP4BbYHxNtoxjoPrC89Nl\\\\\\\\\\\\\\\/lGwpCSZN9Q8iyO4eTmeNZnqdg2sATdVtWACkJnRTXpljUN+m2ftuE5JceREy0NnyoEwTaYQfdyIyM87\\\\\\\\\\\\\\\/F2WX0DHPCUdYdeL1kRXFBuTYWrbDGyIG+83drrETEVXGHWlU7CNeRM+dPpRSmBWoH3iyLNy0sFld7KxLO8YYhaAvRJoIvYueYjytpx3BSM4o\\\\\\\\\\\\\\\/bzy7EmFsWuLuuvtRnpj+KLNx99XiciaZBPcSiBN+BNDglvLG3YH\\\\\\\\\\\\\\\/2XDP46baSrtWnIX3hC5j16Akj3yGcUJWNDSWZJotEo7HgU5+nOVdHd\\\\\\\\\\\\\\\/EIpRMyJzaxjk7GdGMNCxT\\\\\\\\\\\\\\\/NvTEJrBVVDo\\\\\\\\\\\\\\\/FS29t25W6CwuY+r9fLIrzdkWLyBQwWlcL3GlWb1dmLCRNXIPJdkR54oD7U7dPnh5kh9afUsKiyA0Yyct9aC9qksIFZLg1rz0oLZZ2eSowjuJT\\\\\\\\\\\\\\\/AK+nh\\\\\\\\\\\\\\\/ZncIolQ2Q1Rq0WBOq3CHDcsNT1Cm+IyMuepYe9vTmkrnNvsLcvFaAS3BvreCej4chviv+uJB5qHEBKfn7Wp1J9eK\\\\\\\\\\\\\\\/Aih13PfXcLu74nZHVNVk5jSE66s+FsN74768bLWdHevxzzNXCcwHQDfAKl1Wmr4k62BXv6clwjiBLu+PeJOh+kALmYwV49AILVAX6CBuHASud\\\\\\\\\\\\\\\/d7STBrRJ243jphFHQOTvmP89hf+GMz4TD5R9J2QHfgj8rM2V4zMGTrQwqsx1ebOdTt36e\\\\\\\\\\\\\\\/MalQqrMe0RspSrzAFPxYoYaWjAhJtz9byYjJy0CJzUJ8RajsZXCvod7joTuDkWu0V9Je9uuBsrtK0fqn\\\\\\\\\\\\\\\/ed05hxk6ZZhGD3RyUKsidIr4aHrVV1Mc6K55cE76brLOHnovy6y00djz+2Xz1tRIz6PIUTWf8CLNSKyMPUYJUKVO09c6LXOH+OO57yh\\\\\\\\\\\\\\\/tBltYS2o2t5jSma8iAEbL\\\\\\\\\\\\\\\/zk5hedF0\\\\\\\\\\\\\\\/Rhnm5UbYdrckMWBYjPAi+IrNmqGA08Wd8KrlenEoJLYwb5ZVCvN4d43vCKkX2QST3MoFB6wPNXShBfY1oIqZoxzmGRGGUhFDa0apm0CO1TOgpQTU8b4XJ1aUn8K4rTcECR315KegcYIsqQvsgWo66rHtyRQJlx0LWkVEsqv56MHe1UOpD68hlLSel4QHR8fWBQeqTDgLDDZi2p75qvZFqvFupjxsdpp68V59bRzfLanKCFyJQYbEJRXg8qkxqGFOn07HXX2SBNgrFhMrQMY61ITceJHVHUSzE2feC2BhZkLeVq2L5VpYSABBGzHvgEHM9I3oC2vvaPCkYuVp7YzSc61XLcgZeTP+bRy2446VfZxzCEXl00i\\\\\\\\\\\\\\\/Xxa05Mh7cZtMxfQV3tVgG5RlcDlFQBtEh6GhvelCuDB7IyAeTrgJWYhwTuePQJidb2yfJqYzolIC5kNJFWgPfv9Kh8XV9w0I2kipINOPqGJ4vYDTzp4\\\\\\\\\\\\\\\/o7QttINtKzQFrntTA2FmvBGYaKdAvO6zPAPwDKk7eyLZibDPgtUaYsv5W4jQPd+fVyKSM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MIL\\\\\\\\\\\\\\\/T1wClopnWQ5wN+yJrw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022159a8e5939fa314dc6567e2e2e95ddff613e1eb20028219326f0db2520095ed3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e005224.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e005224.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005224\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005224\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005224\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}