{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022QsivEhd77J2TL+iN5vSp9\\\\\\\\\\\\\\\/+jh0IC0kJFyB7x5XZUSt33uyyfTs0EbpQm9QAV3uefTUbGRrw4fKbxzKTOt67Sw\\\\\\\\\\\\\\\/li8HQ3wOJpZ3j5DEbKTaeYqB9laqB1z2GJzdnzkpFvz9C5dXgn1pEhcNy5e1PlVa\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/tygDfDMOBZeJ0cFZsjUoWutJl6KWobZKLT5Y7msoNjkRsdlRZXfqNmesHrTO6aF9jsvgeKmA8+N7iaWZUq4B6TJYnYHO\\\\\\\\\\\\\\\/OgXo8HIMYfwfjfH9wrHZGPrB6dv13CDlenCcPRVLk2k3vdH139OqkV\\\\\\\\\\\\\\\/V7LFe3c4weMPZHbm9YGrsVa6vQoHpVX8WAdf0UCiAsrkHitEBfq2jeK56D10NcL7HkxLtzak2bw+8btBokHJJ9CC5PywTGaoCosCVtl2LWrD+10I9BIDpMw+PTNusSlUxdi7Lyds6WdiXtBMKMizUmiklHgDz9yW7KJTCuEckWlsJvnudPeJoJpXjeQUwQ8Ac2Rkhf4EbQYbr6FWc1a3ohWvGpn43Spp0dj7t20VHSZxOqKGlx3Nm75JESZpT3+Pm9lWo4VCaqPyhPsCEd+gRFNizMUyFCrCg5qxnrtMchTNOuBMvto2K4Te9SevZru6qk65SijpSjrqPlwnWAE062LJuNjx1QPwlj1tM615nPeI6qErs123e8FlakawOboZlIWRFCp7AOstuResge5FP7HTkqk8eKFRCEXfIz5GRRSGGGWfASBvHLAzCYVbvmOTXdcZRKmtTt3J7p8M5jnDNk\\\\\\\\\\\\\\\/HJflHJJEe\\\\\\\\\\\\\\\/ujXROWHRtRth\\\\\\\\\\\\\\\/R7T0Di1hFRaFnsvLF\\\\\\\\\\\\\\\/8nbQerqwGKJ88zRdTJyvQlZXjDSFJ6vbs3kkaimvL6GY8XFJDITSsGA7Pr7bfs+0Mjz1nswtwGBadP3CkdkzR16fobMUc00OtikaMiakX+O4eNZKc5goVHVlqRecQ7Tyd4ZHLCwv7F\\\\\\\\\\\\\\\/s3kyeGy1FIIqq7qRThbEO5wSR4Mbi9FqDODcRBa2pH3mWxDRcDzrX5yMjIVQ+eakeh9tfXDC0k\\\\\\\\\\\\\\\/JAnYCbPYwtEb\\\\\\\\\\\\\\\/CC3THO9Qmdde1WnCzs1anPrSaZFS0Vl5ZDIdHA7drjenPH1xoZjKVVr7UMoaDXKwSQQ8vS1+iev01qCmLGpY0B9fDEg+uwm7C95TpuBDsTFs5WOskJxbDdHmTE2yOe61c8Po8kZ+hWQOWBuBFaOJrTNiassqwyW0rz9dwIwtKYid2y9XPivWPyZyRmqKjIdmJhBS6DDR8km8HZ\\\\\\\\\\\\\\\/O6SHTd8hEsb9N4xxFxvtFumo0jAbOVfaYF3ROZ1GMJKgt1YeoPZDmWQfDX90Pfqfs2+2vneVX7qKjpnpQo3WAWfSoHuaXJX2vvvrDROp51PIfcdMX+8rLRmA0\\\\\\\\\\\\\\\/3Y6hK\\\\\\\\\\\\\\\/PKkO4A334VubsFB4Lqn8sWg0UcZtkQ82O8hG81CnQtrbduZ7+QbdmvZxSqXZKs5CasPUNtzSyaPNcUQLbWJMQNE6zCjAK23VItN5BHKsCNiGUUlYrpjHPhCAcs8UosJn5q10FWNigJSyewCuZa3\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/7zBBA9lBb6IA\\\\\\\\\\\\\\\/TjBdMUpp4i4V3kLAkBVdF7U5DMkbczPpg2zLnobSCS3yQKGVovPyZDw9SHT0kg9KAzTH2kZpB1eI8+fywJn5SB16pJwufjjeGnfOxbKBUPxVCb1ME+Ju5fbW0gQtfZiNi9pV+sSeaL+RwFxxCz+07NlWfnud7paKCYN3OVkd4Bv51LNRQt2d3X6Vgx1Xxs2KLFRjo0tgOSPGJuvOqh0zKxaCqXO+qfZNCNwoPDKYJpYnOQeafpp5t8ftbVlneyRuDQ8MRB4IMuQw7rJYj9n0WgC5Ey5q3RZwvOhaLCEDf+ZWcbMHQjz0WlD\\\\\\\\\\\\\\\/x5VD5gz4nnIobWKU9Yf6qTwBuVNB15DbeUg6ZX3rJfZyEmRVbN90tcNLhFio5QGPjL26SfLTtb7D\\\\\\\\\\\\\\\/JU1LN\\\\\\\\\\\\\\\/vDYwn7S6yhJYGEo9z9ctqR3asQh2StpE7ERDH7DjjnMeLWTA+lpAsGT7L\\\\\\\\\\\\\\\/ybL1kgypPJC7pYuuYNkRGZeAhB\\\\\\\\\\\\\\\/KxzEZ9K\\\\\\\\\\\\\\\/N0bVg\\\\\\\\\\\\\\\/3zuOoOqT3KmJIhhFC3MC0UmWtTK8JMRkNvmI3dOaF+XiTRQDFkS3om59skqTsm5Ijq2V4XpgqmbV5je1HFAFyJ0zMkwIeE5\\\\\\\\\\\\\\\/evhytGdaQJTbaZURfTp0oDtz7JznhdsAKnW5U6RD7OLULvCUH8QyhuDLTKcoGRESd3SVVMHtuZ4aCB3nRIVLfMBCXYmwlOJVl59iwCtZVcN2JFX8VytptuQsw0X8KSw6GESLP1U+By8naWz1nHBxCjarMnA9BpvqE0EtTsgrHd1u33RxDphDxi22Qlh+Emyz6E08gSvWyvQ9Kn\\\\\\\\\\\\\\\/gAi44KVUOdSq\\\\\\\\\\\\\\\/DyegO35gEGoCxw8Ud+PLMlTWkI9Lu0qDyYOK0amU41bdVj3DQDh4Z8iIsZHibHR9hl1ublExHtAdzECsyf9h\\\\\\\\\\\\\\\/QOrH1DPMuLQR6v\\\\\\\\\\\\\\\/TqpMYxEDuEZRNBgsnKHGyqNYFSfqkcPa+p1lGwQi2634XY0DuNbWglc2hs+SGZQ4TKoAt8LCaZKQtoXpBHy80WMCDpFhGdB8kOLBccHjpBBe5xwWTRP74SXl70WnEYwtigSDJtoSc\\\\\\\\\\\\\\\/bq1ZzE+CMUk1yZeiLGs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QD8OCvkVGqQ4J2rHA3\\\\\\\\\\\\\\\/3AA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f724ffa4a40fc96eb2a5fc33a5160daee72eeea67f41616f5796aca84935683c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e005445.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e005445.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005445\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005445\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005445\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}