{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022211lSBqTVRrzHR8wlMEaTs\\\\\\\\\\\\\\\/gkvmHWMQE50iwVVl9cRkkCk3R52EiPAYjujAPCN4aqbP95vX8nk2S0w\\\\\\\\\\\\\\\/qDaUPl8+a+VCD7xTOgv\\\\\\\\\\\\\\\/tKiApVNAy4ZPLAcfyq8gv4Q\\\\\\\\\\\\\\\/vmNf+4oGNJThFogK8egKw2oyGg+Wf6jrKrIAv5foUOArXG2+bWy4FxyL\\\\\\\\\\\\\\\/YhTiR0oMuuzXHbG58GZ\\\\\\\\\\\\\\\/9EzxsGiGvRMMhquAq0JRxakesaHwbKbTy81USDIc9dvZ5yNChODeM69brT2DcfiihyJ\\\\\\\\\\\\\\\/XzzsYqcrNLdwQOh8C8OnHqfuSRTgIOYYdrzM0GktnY2K2B+PD+r0K1\\\\\\\\\\\\\\\/ztzYJik2uiBbb8eTtY71dEQmf9jcBPAXKlRTrvEE2T3WY7bq90ib\\\\\\\\\\\\\\\/GHLueOg5ZWvPxnnKZ8kScmaRmMmr1EqDVIPGBlEO83KgXxYgj+1NDt+nFWxkLICxJsrdN55D394UZuzOJGiC8MnWzP8BYSBLQkpyQlxcOj6zW2Q3Op+fHMKPcSoyVn8nU6prpPnEnjUs0w3p99W3TKN4aIAV5PXk7ukvCwkmLBgcIyrRCxeHkZqGmNoCkjnQbToZqQJHhmiqKIV0rxmtfC\\\\\\\\\\\\\\\/xSjXJYH16uZcXfy+o+axCL8i6xf+cWYf\\\\\\\\\\\\\\\/Kk0CtDtu778JRbMO6DqNY6IhgS3WHlpymuJhB8SGk5sDdLkwhQCh8i2xEl3xYHp6DM8+t6ePA2cK6689YvTqETuiFFQ4B7cDPFIUHcx7qFZFGJwmd+ep5UbJe52C+PIbt8vd4qEPpqWAmB7ZNSevMXZOPRaxMC83M5PQyaXnnSnfMUmYWT4IRrv+5ToMeEYMocyeKma5oKINyyEh3DDp4Flhv6MuhIWfh9hurb4lRs4CxroapTkSETC4tZ0pTTSExOjqAxYKS3zDy1vmc37+fQ6Y57o5\\\\\\\\\\\\\\\/yzhHwsUs9Obb8n7Vg8XrmvFTAn8FHG132qhWaAmCyam48bX0UTd8cKv7pGtjb3+JVALdChQEZhrXRZhMt5H0oMSAKhkHkdbJ6iif2rv+DC4RgNCdtY8l\\\\\\\\\\\\\\\/59rh+espIrCiO0xtvcdmlWV0+tDrWmMT5Qp3Qd6lSF\\\\\\\\\\\\\\\/aZTfjm4hfETYWYPcQgM\\\\\\\\\\\\\\\/91ihpgTuSYlo1GILYMRf12eiZwvoDUrL3Q9Dy4csUWx6QIGfOQmL3JMFIAxbkJ6wj9dl\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/IgezUg5\\\\\\\\\\\\\\\/ZO6cs0Lv8CZohfIo+pJ9bjJ\\\\\\\\\\\\\\\/Snx26ELqi2+G8z6jGKn8TS8dsjCmTztQ2m1CvNQMwPjL+OtI+eUfEjKtTbxPfKB7X1wboPDhHxnEdsktBae\\\\\\\\\\\\\\\/+fRVG6CU6rOno+sc+Z6RKQDZYnnucuKAEQk2VoJhW81qAI\\\\\\\\\\\\\\\/JgMybNNhb0io3fv9AEKcZCQvQiXqNUZbaHL7uodfHBwgwoxxZYCtLwwGRBNZcGPF1fi+hFxWgesGj92f\\\\\\\\\\\\\\\/jJk6BMuui7Wu3Cr17s6gwz5yEc4ZXtW0SarI6voK\\\\\\\\\\\\\\\/EOvTMcLvM1VXIQ8WdA3PTSVk6H3h9h8rvF+iQOBpQ7EtgnmuIbJQsdAZjlUjm+b3qxFf8nCT6dWpak05sfrZqbFOyZm57zhth9QsXKS0+Obup\\\\\\\\\\\\\\\/p7BYTiHUxP4MWDjOkHopiFJ1BO4JxQjNqwMVfTpTbkjfqrNgctPWRRyYZCatfyUe24rNDQoXevIrlNWLFNZuWqTG0guz4\\\\\\\\\\\\\\\/LI\\\\\\\\\\\\\\\/AOYqGKKrJkXbLxpaRXqTipsL934l36KgsOJMBoNAG+6GliD+2mNV5dSFuXsat3bdT9cpXhTlFsGQ7WurEjeGySon\\\\\\\\\\\\\\\/LbrODUhmjO1gsC8U0UDdKIm1Cq2s+Nw+tGkYmau6tqLzwDrl9YNV20aenvKuQc9bqFBOJMzde0xgfFNXlsXAF3r\\\\\\\\\\\\\\\/HJfB1PphaNvmY12kyTohfLr8VboZ3l2BW3sKqQ\\\\\\\\\\\\\\\/gOcRkP6q9sIx4yIu5JNwlUvN5PtxOR9luLSyNrS1PrcCB90kwBJiLypA3R6S+TV45uptSyR+b5aVfSBT8kl6cnRdS9pD+MNb34zuC7A5B1\\\\\\\\\\\\\\\/UWhf6rmZ+5i+rdOwXCytBXQg2yHScTj0rzeTp0lZCHbLeTQtM6alU2iJw9LEmns1aXgGMjCb6rseF9aJsv2vJFYQOT2EQPBOh6\\\\\\\\\\\\\\\/SFjOx5bgYfNSEMcYioZt17vxwmQkI0O6qZTc1tNnujfQQci9y1\\\\\\\\\\\\\\\/cvDS8y21vCh5YtRvjcSEY7Y6lldh1DY6N6+KDLiLTtUZ\\\\\\\\\\\\\\\/9ym8UuEf0NHfZ0qkBd4\\\\\\\\\\\\\\\/Clqx22jheERxZHszIPfNDbtJnFbubImBCyXB7\\\\\\\\\\\\\\\/IUzIgGy4oeSXnFIv9E1Mah2HFNHFa10eCjbEUoOEdAVVyV9WhxV4r\\\\\\\\\\\\\\\/mj5esoR+ASFwq7b6KdwbGfq+6qq\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/YrnOoLyPpUNlK\\\\\\\\\\\\\\\/kKrehl94kUTwBtcxXDO8rM9Uk+uJQhH0GqYzk+nfro9C0XL4sR3UclBFPogtvT\\\\\\\\\\\\\\\/mUD61e0ZnUVS6AkKa0AmJp0CwCH9b80iIpuvAPg3kvBdSZ3koawjz8uEEChXh\\\\\\\\\\\\\\\/1xOVu4uKxrVJNIZLiZML\\\\\\\\\\\\\\\/Rw\\\\\\\\\\\\\\\/iqCxBO62bOO0AEUbieaninHgr4X2k2AUJCwf4nhtH8Jnw\\\\\\\\\\\\\\\/87XhZIPrZx4AG0D5HwxooHVQHGM2OefUyE1IJcWM\\\\\\\\\\\\\\\/YH+bmzx8HAPT8wPQuhv890nOXS68qiK8eb5ajy2TQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jtPmh3dBWqRbaKP1F5ZpBg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225bc0c7904d0b09b830e2659880ac59a4e3b85931599d161b4fdf0012396efd30\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e004794.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e004794.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004794\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004794\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004794\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}