{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220pCGU1+r\\\\\\\\\\\\\\\/d6x8sr7kEmRssgIoQK2BByujEdcBhJdOBimRjeXuf+4IFkiZnqiqSYzNjN9Mn\\\\\\\\\\\\\\\/J4OItClZwxjEUmeNL2vmM9HXk0BU8DtDI0lCXvaPkXIO7b80b6DWXG82wYwYvarRVYIuKGx3WgojpSdgVkcDEyUTzu4tqViJ7zB25B4L9xkcXDeLuPz1iHypubyaYxBT6ntVTkUd9QE1s1lsjs5a3GbRt66oHDcZNgwKJXxUwxIuEYCahW3ikkeDcIj3p\\\\\\\\\\\\\\\/HD2kHnsWmjmID4CHtKFenmOs3xo2eCQMjIN3r+qHvFt\\\\\\\\\\\\\\\/zMSoWyBciijImDHoYCYbkxUveLYmQTxtGDHe9SavKnpuRK23UNFxoxzFox1M71v6ng7\\\\\\\\\\\\\\\/vYVAwVSTJwMX7rGVyKArDWl1PScNBEDvh2nWoIKAg09wRz4OpLoxHZbXm++skNNtj1xV1e+nDysn8Du4Q\\\\\\\\\\\\\\\/YgzqGdajy1AHeTuuhK7WzpCvxJtnFHwhF1OzKmsH00VWNanj7ltuNjOxXnkWUHYHVSxBjrC2Tce5vTwweoA+mv\\\\\\\\\\\\\\\/xqNYDKJiJmk7Q3\\\\\\\\\\\\\\\/A3qiw0ZHXOT2ekDm4FpzBV1+L8bSBnFMl4okOAchuZ+uULYcXmdhf3Rsdmngzcgl4sLNzFJJu2TwK1QrfKqwn5VDaEcK1kIVL3xJ7ceg\\\\\\\\\\\\\\\/kcvgtln39vnhsKkQGb+kYeZSugYuMROmFJ+L0kMBRAgKbJoy7KHzUYWxDOzFR4lRpDY6AehmV8nCwfTS5fSVllmaNW\\\\\\\\\\\\\\\/3Dn3l\\\\\\\\\\\\\\\/vRUIHxanC9v\\\\\\\\\\\\\\\/voJkeITLMiESx2e4BaeSKvHAg8tbchzb9d79H7K1aFd9CG5ejirauPdsbskwAaAuSnYizU2zjew8pYf2ZRojnftOn3\\\\\\\\\\\\\\\/zNI3BgH8Jp0tU\\\\\\\\\\\\\\\/our+suGvDR0APNKfrIvH1sGGYYefv3CnK57yQfgGt7rq5Wpf66CGUtwmPF72S9BwC1b6x5t\\\\\\\\\\\\\\\/3zKDVmyM8LAgmp96VMuxp9hJ2sENmU5qcuSDKkh8Y4SLFH2IWUQw5hBwM3zNOQiX6scva52VC4OsQlXt0E4RP\\\\\\\\\\\\\\\/OksBVjhbtIC8EmWov3gt\\\\\\\\\\\\\\\/WbqxRVcvrPNI\\\\\\\\\\\\\\\/ZfOZK6JnRi7UFEpLsPL2\\\\\\\\\\\\\\\/WlDl7NqQXoiubVGCAoQ0DWbmgtbik8CrRY2GCCFhYQMhsAw5keA\\\\\\\\\\\\\\\/u+eVObD8gPUtb7lVWRwWU+bUc8lEK9ECUwr805PAZxvbcjKFSE7CSv2VdhtlLMwihH5IAzIBj7c+It0GmxgEmGgZu1mjx1Kd+L\\\\\\\\\\\\\\\/lBXfQZKuAKh9bcHwyBDwEsde9+fTTXWUWpsmJ0LGVrbIBwVeOXHeSNh9tFfrkFFTMMFp0X+Ol935y4AysNY76v6dzdAfy+ViGdivRZ7TugkMzAmxBuTQMjRFCalKetIHLITfgSPGQ40jQh8reOmkJId+t+jlPcifwYCLJxyGlXv0oC+oqfOAOq+r+O4udxj0ilihojjcW6t+FKlvst2f+QTXzocYrF1bXi51X7P\\\\\\\\\\\\\\\/4sBsPY2wLSvClYTFO1iIzrT\\\\\\\\\\\\\\\/iG0yh6yHVFt0gKtFMDtxqGHXqK6g4Q1dPcHjfMRWqqLqW7Ymci7r7SyeqosLbPa+xX7POhEwxNzSj8b8CRcjHFEZE4bRMgI55urmcsECDHf1NZoqSEHRaOyKcx0q3wjEaGLqteDA2SA9VI5TMK3UlL3hEtJNRHleZlcSNyTnlYXrYexIOrOJvNN3IUEBc0S+9+fBeWyuPD+TSWOlfr20t2enMg7d6X308ACvBwUl8RUfP\\\\\\\\\\\\\\\/maLVj1Ysv8FvKPRTDhPE+Q5\\\\\\\\\\\\\\\/zGSnwP9CYiaZiF9+K+Ptqwp\\\\\\\\\\\\\\\/0w5k8ul8rzXjW\\\\\\\\\\\\\\\/pY7YCiY0MzTuPv5+GpfsNQUSmvyX00jFken\\\\\\\\\\\\\\\/pfDejh4eF5WUt9QPbYC8j8JcnpL2fSmJHNiA2M6KbE8xL59o207fxfnIGLQX+F691Cu+Pu1hiColg9lx3vtmWU48RnXmAxcLa\\\\\\\\\\\\\\\/gilemHSoEdQZjsDDWlImReE+7vgptMF99QNPa7TIRYZX05DNQto6g8J7osB3i2doqtlsYparKxMl+bQSTUihoV3EijOpSN+xOp+O5ZetdrEjilvOjdeunbmE+jpCEQ6\\\\\\\\\\\\\\\/pq2B4NPKadCG2SBCfJGqvDLWByg++\\\\\\\\\\\\\\\/tFaipzPWLj35bSAhJ5byKxlxoMzcAhitrbzjQBsbzKU2p5s3TZzV2hq2uVscAa9R8jespioIWKXeN8ajqMnIjRSQ5amFZcBiVRIH9pRpgPaHozhlp\\\\\\\\\\\\\\\/B5JJapa5IYmT91NyGD3Sf7XBKde4qDAVPE7sKxGKIMPIv3KdNLFyiEQkAzihbtk93iFx6daa59actGd5vWg40LBfU2DZ8p4a8RSM24oKw4FQ2Np\\\\\\\\\\\\\\\/azQOKqcgySRQ+9eJXt2Dmif5ZO\\\\\\\\\\\\\\\/PXceGqwITeBjs1beIFXEJO\\\\\\\\\\\\\\\/oRgjYXcVoLrSuB3s+dtlL\\\\\\\\\\\\\\\/8puJ6X5AlorsXRVxQ7RoRswWyFrqPXxWwPWGSyXYYvQ2Z\\\\\\\\\\\\\\\/UlfSbmbSO8avct7bPICgutomL81VHvp0X\\\\\\\\\\\\\\\/uCMI5RrAM8gexa+9TEQ1WRughqmGnlp2CNrL72EJzrkNR1MH7HuOWGoxU3tGX3ylE1Coqyp1uC458ZDMQXjc9giFJJ7wJ4CukL0zTPMysoLmlLWFYf1GUMwCj5jd8DVgo\\\\\\\\\\\\\\\/sVm4u0c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022vO3vF1gz96xVbI96B7DQfw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d63f371f5979032755596b3a691a5f0c73ae7779d5fb039856bf549f64f33131\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e004794.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e004794.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004794\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004794\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004794\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}