{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022u\\\\\\\\\\\\\\\/RNi+C95iqx\\\\\\\\\\\\\\\/90pPbwDgWVMEepwN+3ZaMb1nkzyeSnMIx98R9LtfS1nXkK3ktwVu47PIZQ+dQSiNsfQUGZexgJvQA1ZhLqbs7H\\\\\\\\\\\\\\\/NtiThzArvnDWO+waE6rqiy6pqPG1WP4TCCOLstiRAIvt0RiMdkaJuL3+0HlSa\\\\\\\\\\\\\\\/1yVa3EOXndUcmOcT4UBfKMsEh+\\\\\\\\\\\\\\\/DL0u8uLcBFbwFXbNBezF6Fu\\\\\\\\\\\\\\\/61imxNObbt30lVjCFFwqCF7syujsx1\\\\\\\\\\\\\\\/zXhS+37Fxq503WCGK9PckbZs8tCaajmJumc2mvXhWwAWRtwm\\\\\\\\\\\\\\\/3BKjD5uqLj2Rrpq\\\\\\\\\\\\\\\/Ome+HuAN8kuwtg2trg4ptwSZyAtSBhn5LtaNXj0MDW7gptXrVuHzcQLaosHrAbyBT1ZVp8uCzo1YLRP4pfQbcja\\\\\\\\\\\\\\\/27FPQ9zk2rNAX2YT59yahYyfYgaAiuy8KXsTetRBqdyQ+L7okfKqHQh0ui\\\\\\\\\\\\\\\/cJQiXNWnZCJ0TBjw\\\\\\\\\\\\\\\/J669faSue2pXwisk02I\\\\\\\\\\\\\\\/rYusEMZvdGmzvk6FlAfMa+6oHozdrSaOmToqhhvPeSL381wwuMsupirYv+GdY5QJcs3fqxqT39EcBLtmT7WzYeAWA1RY\\\\\\\\\\\\\\\/kj2s8todChavyNCHPTEt5WVTd6KPK+UuJHw\\\\\\\\\\\\\\\/XbTsPgnrwqP480Ckf0akvNsrfi5PttFXE6nIpLcEtzYD54LegPAt\\\\\\\\\\\\\\\/eByJmkBv5UcQYLTXHe5dnxtaEbEdk\\\\\\\\\\\\\\\/FDEqWbtJBRkXW1v4lYgSKYOGOOlSgMeePD3+QjEuSTcviNfvT7n6uN8Lyx1Z6lcnqkk2aB3EbDkHDvck6yKE0n7oGXQjzvDSXqtglO1daF+m4gIPKobldz1FXVzIN\\\\\\\\\\\\\\\/hk3cHGRm8B3N5FVy3O0DYd6frsMnTJn8RlMHJvqFKlkBwP58GOy2TvVPEioRWHSEQj3CkPHUAWmvp0RH6uTiyjGrQcyO1IZaujTFQfXtVPmS\\\\\\\\\\\\\\\/w9I+wV+U2k\\\\\\\\\\\\\\\/h8uR0hXHtvTT555FE5Oui0T88kFx3rr0WkVeG3pKxvQnTDw5wQm\\\\\\\\\\\\\\\/ItrOwvHwA\\\\\\\\\\\\\\\/mfr0J+3U1m1tKizEgbYFwWFuD8A9JfBWnt+VgitVrGbneMxXoXWSnuN+ZNe1oLqtE1Aam12VYY3dASDuqE9h+bJPfByFkc48REgosenaZyersrJkGm1KZaBoA23JmNwomD8wxushiCefiOrqRg4t5nYH8q0xzio5xNbLTEvmhYCG5PRakfemDTDaaWI7v1nE6TkxF0Kr1JFmjxSzUmp28lk8VKCvWM3\\\\\\\\\\\\\\\/1CF0E1mYI5OQ9Fbgbk4jVTAJ0Rsq9u8wABKumelFc2iFlAHBHEMqbTMihjAsa9xo+2Id3I+UD7qyksbAhNjt3OoTVvhtT0TU5K0m4LpwLo4NDD4lRcGj\\\\\\\\\\\\\\\/CkZBr+4WnlL73SFUmWRFa+3ImMmWuAxFKwOG\\\\\\\\\\\\\\\/26U7Nbs8\\\\\\\\\\\\\\\/hSxkSiMDUhN6IWY05ULaDma4qUzoE3G7bx72JTTHZ6oVenEwt4WEnZMijiUn27Kvm1pk2q1iJEErT74\\\\\\\\\\\\\\\/tNChhEgS5vc4GhcObuPM8r0N6ab5fGwkVhUr6NrEzh340p++AmTdKpeEeAFvsnXTmCw9YsSrvbFU0OCh5XHDWsda6YfCFu4DgSJUTp5cpYZgLTSFW\\\\\\\\\\\\\\\/YQF\\\\\\\\\\\\\\\/5A2ye29fjYphTA0LbakAlM6mccYo62+cLMzYAzdK4FExSevMgbUd+uE7iiHQv3dUq0PkD4WOK66gl2l\\\\\\\\\\\\\\\/ktVLWVJsTV5Kx0Sev1YtBLSFCBWsbNeAjVrut66Dv91ubad9va3JOEtHZ8TxZ6K1K5qtw9p1oAWi6Sba62Wbvz6Dr7ChGj9x81FLj5kIWtIgF1um2KJ0L\\\\\\\\\\\\\\\/IbkRIB3AD1Mc\\\\\\\\\\\\\\\/E+NMR1fg6WrtATF1UQZVo+MduGMCQdXWPb9rrKtR3qrCstDTApxUxON6M3npj3UEOuc22ie+kYAvGUMPSBg0L16SJ2YpBh86ECeUOZD1nM2dp1UymwdSIj15WdATThTBa9liKoKJpUUgq+fHFWuUFeJXpNoKePpVryDOJLdD1vUStfTLHp9J8QYieO1ae3pesL\\\\\\\\\\\\\\\/xT2s+QCC+9tjF3iL5MKFSbxV66uny7sS6aMrWUzJbE+by5Gb++x5C0b3IuKpxcCiExR33QL84eB35YKq6XOX23NE91AOGWCEf3NRCNqVt5n2W\\\\\\\\\\\\\\\/elXo1yIxhokDj2R75zzlyHV90AL1YHeMYxpU0iaW3iTSwc7v6WWl724ZPsSaEHi3ScC8aH\\\\\\\\\\\\\\\/ORMR9kGF0cJPVsnP5Z0NnYV0HwQo0DnVfiQzFRDjBRJtz13vVzs2jlOp0GvDsP\\\\\\\\\\\\\\\/5m+sV2zMUrEMdCZ8PHwFCMzjPFckV93AgPYIldjWLEot5gLs8VpcqniMSHhv7DWAmNKtKRvJDPu84PbzaHuYgD+8D5l+Bx8YSNR4Z4Ty0ljNJNuGAmiC9CDsvf5QNSVbHwWEjaCDr1po6ua2nQ+A3nICxNv4qkciMOuJ2qvc+KWJT6l44N\\\\\\\\\\\\\\\/rU9fbKr2yHBxCDyZ+HHNPPVDlk42FbP72mPTFZR7Ueevgn4P5c2EYP+GXFKZlKULMhKQvspIuTx6M1uzJjogJWZ6boQXAeAWcjzrIfQ1hWUlUBOkkUIZOY\\\\\\\\\\\\\\\/Y2ojaJgVOUhiRgTOstcZp+VArYhPHbW034PYNrHKrtQ76rOYJOLfkpt9c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00225OnIBHUINDT\\\\\\\\\\\\\\\/TdRcJkJyqw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224747d8fb9f3d86dba94ea23f7ec0b2562efd33f63810252ddf6d66b46ccf4e3d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e005345.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e005345.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005345\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005345\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005345\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}