{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022vBh404PQnqLBTISI9kKyHdSSnoZuLn4pf7anb1z5AbhCCPQ8cqOJuOd6ICrLos3bAODdlNwzfFvCGaDApt\\\\\\\\\\\\\\\/raTTJ2AkgA\\\\\\\\\\\\\\\/LyCAHW8o8CsfEjdil5jXruHxiUca4HAa4Lmk4qTfy+pqbaN3OW9O1E7drV5UxLrUbWWSyq5GFXgaIzyTjmxA5tNZRhP9qZxwWJmjySvZF73K1huiIkhL5639h52NBTd1xUpZv\\\\\\\\\\\\\\\/JN7CLJXKGsrplgeUNKYEMoqjKKsRhmtu4iILeqJs0sb7a2ViyBLVozak5RH0wtEyOJaMQKLNADJWQbE7fQ7r+PzUYsLCrK6nBw8\\\\\\\\\\\\\\\/fAejeEx3xwLbIboWTPTzdSL+KfsNzZdoWwNMG8UJSdVaPzM2\\\\\\\\\\\\\\\/ug9W3+VYy1zVPajq9DLYVzYul837aoT5VM6U8wEn9FhHVjnPO6jr2Fkc1tnkWePIAwKW+vVp1CO6WoOSXWT+zM0serSSoHY\\\\\\\\\\\\\\\/yd\\\\\\\\\\\\\\\/5amPsPgfcXiRM+cfhK6rB1MxL97Ho9pfTLzt8hvRL65H69HqR9WwMyu7jonRfvTDRU81wuhQ8np2j9l7BWb22qF50kpkijtsFuzvTSTqlCUQaMBq\\\\\\\\\\\\\\\/z3ae\\\\\\\\\\\\\\\/vi3M2NbIt3LJnItpDwdMcUVnqr51hvVac2YEBH09oliMEbRFdI1dQFxTWCXQ8Jv0jETgSjnZDtxACtRhwRSZ2psFDdWySq2wZ5bzSA6DSB\\\\\\\\\\\\\\\/XOTknn6ZCKqD\\\\\\\\\\\\\\\/hm7SDOAdrFLGRJp+9xKy9xsKhBcSjT2YBk9Tpu3eH004P37tjGGZ6v+Ps0myix\\\\\\\\\\\\\\\/SZ1iOYBaK6w69bwVTBWRFdzD3Xma+cNUX\\\\\\\\\\\\\\\/MA9QB6g5UzJ\\\\\\\\\\\\\\\/Q0y069rjo5S46ua2oAE\\\\\\\\\\\\\\\/61T7ShNOUASIujZPn2ItRnSDaQTlEQM8yyNnrkiKGbGPWgtgpvYHaPHuX16Q3rIhEaOAym6n+Yb5wnc3ByIr5Htz+jFYCpgdS4ahwM0no6cpHodaKdpVhrXD9ANitDdK3gO+kXrpEHNU9ON2gFsNJ9WQrXMFC\\\\\\\\\\\\\\\/Y0pgBVajoBPw7OvlOEIzwJaZOosVmFyinmf5pz4icurEgHpobOnweb2pHTlloVia2BqdNmQAamkE3zhBAzn\\\\\\\\\\\\\\\/PYRlUWpk6b0HxVBQIlGoBBAeO+fQQvzb14RFMq6MTHYC6c\\\\\\\\\\\\\\\/uEP6CY36foa6DtATVnGk\\\\\\\\\\\\\\\/GhBNA5Z8Hd4\\\\\\\\\\\\\\\/tasFIg7KMtGJXEKAqFfnstQ4QK4SYckv5c5VBzwLup81QPFXQMb9vs08bll+5Sli1BOvO1KUNg7SHdC2+qkh\\\\\\\\\\\\\\\/RFBDWnob263VRqz5m2gWWc7OSGhh3WSCp+02PNiuEVSOVf+b2G7uhJNQ4qSCvhIYuYWFgT+pVLvWBlXClB6vCAy5TS6omikGYtJJwH2PLwdORJD0kdTcxSeBLtlycm1cYWAhPMNBQWpaek+1ZDuI9lNnoA8T04GKcY\\\\\\\\\\\\\\\/lruEmtd4LCOOxdOMjcHrxp3lPsCFjg+xK7KOU9bGDL2Bjt1antJXJFDien3SV+o3\\\\\\\\\\\\\\\/s3PZryrocGMQGj1WudflSXTTOj8Ggh6G6GCWZG+8eNzmixt+AE3y3+tobchFl9\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/3+YqIrWtDswbwnD4iA0590Mec2JvJ8eqhGIizT6LwrMccqL\\\\\\\\\\\\\\\/YCwUK\\\\\\\\\\\\\\\/KYaTPJaYUXpF8diqU2nTz9krunQ9aI5XTBAiApvnztjgaQRIlmibt9\\\\\\\\\\\\\\\/7rG2kAzwtcaoFLieC\\\\\\\\\\\\\\\/3bftXFSTbkvS+P1koub9H3plddxImGSanA3vBn\\\\\\\\\\\\\\\/RCetUd8D2aDhhI3amD0Fq7OHtmIHijBFWKzUXj40EwBJu8FoY6Nztddnn5M+tAnDXfgwuUa\\\\\\\\\\\\\\\/G4dx9smY0R7+FvkSfB4dhV2pbsimXMP6b+Xpp3UvqhzyUSyfYP3jzWNWVKwI5sE4Rss3QcIGcI7tI+NIvGsI1dHmQ985batBExwfCkwKOv7E4GbD+QMosdTKWj3YxCWy\\\\\\\\\\\\\\\/6tnU+vbaL7f85x+1xA+9G221\\\\\\\\\\\\\\\/vfLVVb2XAPMQoyJkk0GjYneSXeeZch\\\\\\\\\\\\\\\/Si6oLg54NexrZ1XLGJ\\\\\\\\\\\\\\\/uOWeHsev1jgkUbO6Bq7wzHaGk0oQCs0fAbwKdjsWgq9C45AVpJzrq6kMPdsp0\\\\\\\\\\\\\\\/c+u3ZkTDOJ\\\\\\\\\\\\\\\/lE32VrEElE+b\\\\\\\\\\\\\\\/Wd\\\\\\\\\\\\\\\/MC2t1nT4cNgC2Vvex556moknCqqZVUmgj4\\\\\\\\\\\\\\\/QreBstIorVYv6YAjjFdczhd2WcBSXUtLSTrzqpDbx1VWSLxg3adcXw\\\\\\\\\\\\\\\/rxdadtFumdwwv82VkAKFDnUEElNysOREwvRlFAI9qf9I\\\\\\\\\\\\\\\/8nS3OghRgA0KjKZbLvcrUc7f74KTvKDwr18Ty42nH\\\\\\\\\\\\\\\/seXP3iFxy7uzEH4tjXGTzqO6L\\\\\\\\\\\\\\\/9oGZVeOuqR2d7zZglf9\\\\\\\\\\\\\\\/W\\\\\\\\\\\\\\\/7YTA9A0QC+N3yOiInIYVErfs7v4sKKKPj\\\\\\\\\\\\\\\/RfKJJcMCNDMFAN4nnqZmvGU0Ms+ciQbMDit9nApMvnyZWIjIdFN\\\\\\\\\\\\\\\/JcgcMQbQk7\\\\\\\\\\\\\\\/R3e6lH\\\\\\\\\\\\\\\/SWrCu5SiJio6LC2gYHOpcN3G8X1BlSMraVv9XWxyD1pxyrOZxWRQz3F2C\\\\\\\\\\\\\\\/lYWVE0b7cnuii4j3GdZTJ7wuNs1JKKu65zfW4itIooDCGiBD6TWu3CbLezjroR68RDAu18xENY8cPqadmVhtrrvPEO0HkwZXHvS8JclU5qn\\\\\\\\\\\\\\\/51kLP+8pZUzLxgnj2LfF05\\\\\\\\\\\\\\\/xtQFaG29PDPM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022gwPbtfzjKwGHmRgVeoZfKA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002271644ce4c52d4147fd1932dec0eeed1cea9dc6b962fa22cd2f2a666b4e67c90b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e006082.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e006082.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-006082\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-006082\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-006082\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}