{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Sog1jYkhhXi5msahTBShLkOCfwJ7zCQs1aDzRqO\\\\\\\\\\\\\\\/8BNvrTtB+B0B4z4k5Iyb75Ukcgiyzdxx5wVXJlVcAxucEtJfQT6zTZtG6d87I9Yqq1TpduwwrjiQg4ToNHc1pI7Vyi35izu1gi1IztWqxp1zwGbV7X5dOONm\\\\\\\\\\\\\\\/Q\\\\\\\\\\\\\\\/RwRoXDBXffBX1KDxwU8ykWmKu989NowFUAs+qO8wwEHDDLcDZTZNBkU33BsuuUS848+Lt57oMuKvKQJcZnL4b4b6ScVbNlXEE3jfS6B2mMpHscrXZaRFpDBnx5NfsGObz\\\\\\\\\\\\\\\/6p9A+O0NWXkV3zEX2DKmnnRLOVC9VLCZHUO7cjSGVheAbOkijW5xDRZSJp95OVACzmECl9Yo0dNSdYRl9V1T\\\\\\\\\\\\\\\/rIqirlhJE2FLa7xQUy04RUPzL96RNtY+gK\\\\\\\\\\\\\\\/rFS0VY3BwgHy2CtmjdiBXZt5IqNOYtxKUb2AVP6yWi+7COSmfvCvL3o3ksiCKIIa1pTt3T24D7oOA0dy3yTrWXd9YZofVobEBwdNMOqM1j4wB69P60cF0+MeXvtVdgrY6vOCgeD9mjlOM2t1z79SW8jNiRpb9SO7Fj1dz9s1eoZHW6gIxh3WwDY3jRM38faaQJYCoy6xr\\\\\\\\\\\\\\\/fJ3w+FXBMbRpaa1cIp7UhpY\\\\\\\\\\\\\\\/4HFaaXUdTID1SNVspQv0se+bL9musDERlyU9zhf8jpSfyg0pyG9d+83SARVktzwLbPUpHxIOTuirJ5\\\\\\\\\\\\\\\/m12QtPFCVd0\\\\\\\\\\\\\\\/uDZeqtj+KTs5XJ\\\\\\\\\\\\\\\/8dSz7Ax3Nf0VE+nFSB\\\\\\\\\\\\\\\/RHZtDxa7k\\\\\\\\\\\\\\\/DWbZxewjYs90wQxTqURoaVefE7F1GQimR\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/xWwVMeCvL8hkFVirpCbRC\\\\\\\\\\\\\\\/GfNGuFcCAzfglOLiE6ym7KJK6v395nTnlbKueQemczKePRnb5nidsvbfSXM2kQtMAIoqm7T0WUjA0IOnCW+HbIvkGbbk2GhxeNUyEql\\\\\\\\\\\\\\\/HKp3cLgoTh8WBGxr06Mr9dLD\\\\\\\\\\\\\\\/L8CP\\\\\\\\\\\\\\\/I+2EsjYRqGgPNUQJyU4o0cgXE5wuvA0GICh6VA219wO908lYJdrL1VA8Rvo5ZPk80hJf2EusAOWOCfFM4Xe0IKdblejxAKRjtPnyd2wl\\\\\\\\\\\\\\\/NsJBXyQkb8t6LVDH7o\\\\\\\\\\\\\\\/TXgxo+Xv0Mz4GDCicHT4oe97chwkSNqvPsLiNnPPjyOAEEDamB5Ruiy7iklOCiyzoYj233BVUOKuH3vb\\\\\\\\\\\\\\\/o2PE4XGu6WjTYoHnW6\\\\\\\\\\\\\\\/CHOQr0oumuJ\\\\\\\\\\\\\\\/QRLp5vsU5L1q59SvjIhwjKoMoO7sZhQWcgqB+q\\\\\\\\\\\\\\\/ZPGZfBORNLJQu+S3llmT5MWEuNrGA9m7OaC8xnfQUN\\\\\\\\\\\\\\\/9Qs8DNlgbvmg3rO7yMCiyI1ODtGRbkuGGprWgczWdQJNtNoqtHFK1MWzNaf+es73w4Ox1lPk9ZJO\\\\\\\\\\\\\\\/ed9CmrImtEBGg6ArxGfL\\\\\\\\\\\\\\\/dm4XBeRToUx\\\\\\\\\\\\\\\/cXBWGvIwOV5+BT2psMi3m+6eLoJiomyonYc3ScuBJQkrbxMvYdOWzxxRv9BJ7NpTIp9DP5JW7+VV6liqxeORCiQH9yEcHUGvXVCUfPfmblKSHfmmpyjEptkUYIC0Ozqm\\\\\\\\\\\\\\\/W++uAvSXCL+CY5ZpA+yJRTezoWdxt6TAYCwXEXtyBVV0iFYTt8Vf3IvQoyoOaGhYUYFJzz18QQrt51\\\\\\\\\\\\\\\/DK\\\\\\\\\\\\\\\/BHkSIlWTK4vRCVGnGmFuPpXeomRdDQMBCwacPybOJaCrGzsNMn3cCAyQ2mD7nYyeq6tTQNauhaB70inoaEqi8XujG+LqMBVBreiedTf+K7efsfjZCzri2jBC\\\\\\\\\\\\\\\/Gcti+8yBUxLxfJNIeqdw6X5LtqbO1rnw3dq9Vi+iqFTAuiVi\\\\\\\\\\\\\\\/DyUhO4oKsmHWLroV4qbiTR4FoIZJMUcSxbOOmhW\\\\\\\\\\\\\\\/6trI6cyrDMi3AkOAmwubb1\\\\\\\\\\\\\\\/I5K4QDJHsNcZ8mPrTZo9ICnbs3AHCl\\\\\\\\\\\\\\\/ivJZMRpK\\\\\\\\\\\\\\\/2cNCsrU20PI9Cmhq2fk1NuqcH034QNe5FRSOJnbW8xgMJusg66JAksTBsWaHjM4MVZs\\\\\\\\\\\\\\\/PQZ2ae51gsSO7Qg3AQrXl0clSC5wk\\\\\\\\\\\\\\\/WwuiWl6KiseF5IqvdhjzHZM+sktscdA7jGDzeOJWyeXTtSNV8VDjFl5oo7tVbEUoGDeikBdEk7zU55KBalBlcuuO9qUpPZC6v4XvzZW0xEfqU\\\\\\\\\\\\\\\/9tyIdNhqEoqG2H9zWIFb\\\\\\\\\\\\\\\/TR358WqSNLN01q2Ym2CmOqalxxSo2tQzfBJ\\\\\\\\\\\\\\\/BI\\\\\\\\\\\\\\\/X5LjTA9\\\\\\\\\\\\\\\/C6KEkiYvOw9M+J1CbPHj8AFye+QQFl82vpTJD1XYI9gR5zRXq6AOnuiS4xlmYFpWa7FFlW1OcRs\\\\\\\\\\\\\\\/A4Y9U6u1Gv1rRy1551pb0GwN187bkefuF7LwhL0mEc7+baloMg8KS2vxoQgNf0V72g5q\\\\\\\\\\\\\\\/DCpzdj+TnATfJvOKJHQL30x6TfJBBTWzfAPBvlpVbng7Y\\\\\\\\\\\\\\\/WDKGkSSoDD6TIDVAAX9T7Ny0QeyxKj0gE238Kyv+bKDz6JFGSmF+Z8Xj2Nvx\\\\\\\\\\\\\\\/urBSe60MxJ+gYNAyHEkMqahauuuJ5HczcUl9VKrYOeTBu+DnXKFy\\\\\\\\\\\\\\\/OHfD2LGAbuW6KbLoOkDsM77z2gGHF63fWfwF6GVyamSU6ZO0jVl81gUh50Bn4dGmh3NkSX9LVs0QLdadkFrq6\\\\\\\\\\\\\\\/5hpWmhWRlMS\\\\\\\\\\\\\\\/tSRCxom+usI5fJ45sv9PcGr68iV+I7puKLWAu9Gwezuvc4c=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022y0EWv2Yko2fsIFGaz\\\\\\\\\\\\\\\/i55g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223dfc47811e3696e2b45219712ef5f8076012f03b0ac4bb7bd3fa86d56ba21593\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/12\\\/e005543.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/12\\\/e005543.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005543\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005543\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005543\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}