{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022H\\\\\\\\\\\\\\\/hf0UszcMEQPOrLSyaC1lMyRP4xtDfEZ5bjRW+picIR0FY\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UPBINC2KSaYzxIYLXB8+2D8Jjc4JNiZiLqJUL9DmWBu9wE\\\\\\\\\\\\\\\/b7a09vHKcNWcn6cUMkT3YDu\\\\\\\\\\\\\\\/Baji\\\\\\\\\\\\\\\/zl6724nleaFTttO8DDY1BC5oaH\\\\\\\\\\\\\\\/66RGnuO\\\\\\\\\\\\\\\/zHI6TP0SYs\\\\\\\\\\\\\\\/Io4X2KqPqgRaoATjZiYuM17nRAbioF8dbFOoO9gWiYtjWyw5bO0m8SfOL4mX70gICkl7Nw5V9LrkKZq5\\\\\\\\\\\\\\\/lB8oNJEgNFnRIo26f2LZpKDdlUPD5ph8YykHolU1xRcxuRO29In+KCpFUbKoI+bAjuL4zXWAjJq\\\\\\\\\\\\\\\/xEzEYyKxINgyBWXZfNYUodDwi7wTJHVQYYLqqf8DxEvU2xx\\\\\\\\\\\\\\\/EyC6tboZyVyAuRHMDGhYim4j25L8NdblKtcyjrI8VSkFSykabJwWm9z86W+APS6OS0Amf6noV3e0tUw6YnxfDGpUM+xmv4Ui9prEpwYYOHtt34PdBBB4llqe4jVDBYJkyzYatSf0mDaeQx6kGzczPJQHk\\\\\\\\\\\\\\\/c1CI+IlhaQicb5OEzVcey+zJEkaJaFBRT39Vga2Ft36oPlsJnnzuRQeDosgUIlcx\\\\\\\\\\\\\\\/y5r4U73eoTGpq20FH9gYQ+bDDax3zWGwCoG3L89SapKDNXgK3SOv0XXw1PV\\\\\\\\\\\\\\\/bfvnASAYWcQysdoqGOXnAXXh81JJPwpwZLEHKJu5D7AmKwaqjR3WefNcNmWiLFBNkK1o4v9nuuCTwEcrSRRHotnUdVW5FdWveIFLJaNbCZIHV4b4+rA474V8kav0AOcD4oAXjj0WZFfG537JQBY30fEJ\\\\\\\\\\\\\\\/5NEhN2iynl0ngbhjXRpNUOKRaXeq0erLAoUH+S31hIoUQMA+dVdKRcysX7f3opVhyR8yAqDPGywRE+k5VXP6kGGR36T0Spl1dnGrsM7dHHtqtBePm0o\\\\\\\\\\\\\\\/hkCKeJXcxe\\\\\\\\\\\\\\\/sUY4SOHirOd8XwwGVY8Mq\\\\\\\\\\\\\\\/e7HKe8pS8ykZCWXi9sLabbysKXJpZ720vNZ0r9E6PW7nvHzliwUknm7Ftvr6u0c8sKQoQUhfZjB8+wbQk8S3DzvTayNESrAuVKrIAjTIPM\\\\\\\\\\\\\\\/GL0eOCPqz9jTAiS7czzVxKHQKZGYqTLwzXEyyCQMqstxMT2jkl6kHg33Igjg0FjDFSygp7Ae0q48e\\\\\\\\\\\\\\\/6aLF23wyQsslq6jiWA50qfUhoBj8iRoACHGHO8XNbhL5CEobKLg2UnXCalt6BSY7omQM9SPvvKV\\\\\\\\\\\\\\\/IzOrowfN4ktNCk6dFR4t7lYyon3AVRiB1VcLlER77bvW8ktQv\\\\\\\\\\\\\\\/Fj8k9lZNdKlL2X8EAW3QUg39MbzfliLGAoJfcrLrJoebJ75gY8g0NHPcUmVBhXLnwupjHoz8MMjWfyeyJMJPCFm7bd0007E9nkcqod5s6XVwCdipQxFlv0J+2FiJM+zR\\\\\\\\\\\\\\\/SZ9AJsckq8hsrK4K1HzJV1pivf1Z\\\\\\\\\\\\\\\/ZClm4qWfRDuGafI\\\\\\\\\\\\\\\/4hhm4uAhSZCYqQ7XOoKUaJ+uKvvoWQXslA8LB9PrQgp\\\\\\\\\\\\\\\/IOpq\\\\\\\\\\\\\\\/vgvuHXry7HiqwbSyj0tNP5TNjPzb9PhR\\\\\\\\\\\\\\\/GfTKqtxA4VYVu\\\\\\\\\\\\\\\/PYgfCVKY4E8dkGpnPIxeXKOxUNUs9slroo\\\\\\\\\\\\\\\/gVOv1rE+oMZe6xw9Z9YoMhMK\\\\\\\\\\\\\\\/Wy4CZ59Tji2HjFTYHFQfez55Lr3bx1Qn59f8bwxQ2j2mSSceQ4gJGAIhWypDyJrDAPNVn0v6YUf1iqHpQp3mgJE1y68Ip5ruy\\\\\\\\\\\\\\\/QI5uNrGa7P+S5z7psXuwAV2ROieyTrtDaevVv6pLaMZjUB0klq4utiUygwzYCzl5RQCCCOxuIf4GvqC67pUP9qKNOa3W\\\\\\\\\\\\\\\/HEZSO9mfF85RH2Xh07wGWwYK4xAgm9xSP6yMMoqYjLgnjbEF7qpx5FSJl4Ogvw1+isawrG3KgUxG8qoEmSnQxbHIWmZFSdXzWJefB4ZRkHWOWUrKnyvxKS3zRJ6MujDv722tJhFLfu005JZz4UhrBNvOWIf\\\\\\\\\\\\\\\/gw9yuj89cz\\\\\\\\\\\\\\\/rwGnrX5ZNbLZFkjUS1ZM+XNEcH6GZaiZC879hGiQTCXkcTitZeSJfaCpfFEapGJQN9W4hYuyLJIa9d3C7xaNWXH72ThvWTickgvatbNI1dwK8gJd194qDZ4WwHEQAtFDnJnMhQ68hMcyRF+NtwyBT3C0HRlkFq5iYewNTlYJX3ck\\\\\\\\\\\\\\\/5ev\\\\\\\\\\\\\\\/Wi0O50eTMvZfwkz2+ucAY1DXyYCxsxyKLRH99MmJIDQs+7+ZTUby+YdF81XxlTJCBRuaaxy4yIYdXp+xGJ9i82EjEJx+tCj8GvBAMhTDXCgcN6rJeLbynZtwcISlT90q6fUz170vEgybHBsSU9DEaMh8e4FOiPgWB+y7G6uL8hx6EyrfBecKHr8dRDps1ZqTCW5HQrVDZitVhlI+Wr\\\\\\\\\\\\\\\/fkLaXS\\\\\\\\\\\\\\\/sshHA\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/QyZM0IuUzgLSw9c41TORDSo9mpKKuEs0chF2smZdZdnjLlNpBl1o8hR7h019rm8d5jMg7naPk3Uaa5odQCZ2kaVlY\\\\\\\\\\\\\\\/Mmy8G0oGgrhVu+GAGjb3ETEideiQ1NN4p2oXFGwEdgTa4Oj4zW44WQwpvPDbdEPyHjfJVhjbsum17Cq3wDBQX4ZNZFC46sWMFHCkLwhjpB4Dsl4ilMoyfe0Eg7GMFeiqR2JAd1ysgYUiWCIcKibxlO9Gdu0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MR3cDngCf6YddPwMreBY2A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226d4e48ce8838076e1475ef705a2111d983f9423c986a5d19c1a4bf8e46b67ad8\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e005459.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e005459.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005459\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005459\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005459\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}