{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022BIEtzjVQzjEnoJ6URx1KSZfyPzRVsWnNgfb97jsUK66VOn7QDw58GM9WCGZAPdNXgMSo1Qf9MLvwViOnZiKhpIfR17fj04RWuYYJf6CF3dLsaSzCW8AUePUuX6mKAfSbRAKBedDg\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/JvkbsyiDE+heJD0S7TXfHS+PrU6M4jcEFup\\\\\\\\\\\\\\\/rbdEcVhEuhOnAfS3THVtAE7UlH1yT7cAYBMtGsOyBJCmqC4\\\\\\\\\\\\\\\/XfzyfDyzStfdVxePgh+CTdXo8PPOx+jKQJUFKc5l+wEbkzsgqOx7nSC9NfP7ZmnMIa0ri2QlnomwJZOqMLE9sXYfPMIzPwL9X1uemNK+ZDQlmxDaSn3Bs920HAYZ0xVqAuecqcCLVEz1pJegwYAjidxCCNnJNg\\\\\\\\\\\\\\\/wWhJV04gVfrkZCcTC1jY\\\\\\\\\\\\\\\/Q69mAESm2rqSfPpnzJ3MnzDA62U5esU1mD80aIVHuVb0FVfLrEsSRxZY063HBDion1f8Yw2R6OHzRvQ8XtRY1v8PchN9u11hXu\\\\\\\\\\\\\\\/LKKNeJjhE7lj0KKqVOGMU213ZfLIQhUgb1NNUJke3Ft3Y1Gz7H44mDMXAYAVbm3IpcE9yTyw5t\\\\\\\\\\\\\\\/BT6hVmn5ceNRspSHOPAmxQS+dpR2bCTb2XmTX0+Kj8hnnl3l+N\\\\\\\\\\\\\\\/OOuVGzHecHvbkmxkzEw2X2ewf\\\\\\\\\\\\\\\/4LCfStJ8z9dVC5IMPBWq6DWazPrEdyOl8h80rOJsWbNgLUQn5UgFm3ONEbgvq0rutBPB+1TJoRRuC0\\\\\\\\\\\\\\\/yMKPMBnlb6Yng6nzmpH7pbM4Sqnc0a9jEjmAIIsfd7w+cHixdyqvv4p2k39UCYkxRGc\\\\\\\\\\\\\\\/M0UoynTgPvYS\\\\\\\\\\\\\\\/WuSrPviuuZ2kp7J20Af2u8TdZWMX+efYSwTdPoD\\\\\\\\\\\\\\\/Zoew3x2F1BM2kSK8BXnNo+GbuFiD7qW7NLIRheL5uaEQ2MVpCex3ZnnIlb6E6BMKf22R18\\\\\\\\\\\\\\\/2J4ZPtkSuf\\\\\\\\\\\\\\\/QyyWpgN8SIatYXhrZ5YNdAP+BbgQ4XnjdPoZ211R421qvtNyJINUwFKq2duQ8\\\\\\\\\\\\\\\/Tdw67UM9wnIDQWf0ZwlZsTq0JJ0S0WYUsiYvI76o2vhyi0mqmLNJs7rWSQ772qeLR4Key3sroeaU7wOYwsDv1zwFXjnZeR3r7dUWEDvEa44q\\\\\\\\\\\\\\\/rzZ5XHQ9nnJwjtirRtjpLc6q\\\\\\\\\\\\\\\/DawlBznGPzQrsJSDo4l7X\\\\\\\\\\\\\\\/ojtEk+eg9MI9ah4F2eAaN8HkXJDrz91gO43oC1sG1Y2wEXJoKeo1TDJpJV8kWX1GVsXtOrID3g2H5kXjmWU3a7ODK+rTqCXmOFI8fb5I7LYQgq0r1\\\\\\\\\\\\\\\/tVDtKLqoBjlyMSW5Ya2kWD9TA+\\\\\\\\\\\\\\\/XujDvBedLEIZBtjIg80dkej40sFhF2sdhmH\\\\\\\\\\\\\\\/jorfySrGOEbZ2+sVTMPL+NIgAb1HQ8xNt36uKD+4342kDe7JAOTb9AZ0fhK7u1KIwPnMWaLrxcguLDE4WyO00fQbjLamxg30F7K\\\\\\\\\\\\\\\/R9WgV6\\\\\\\\\\\\\\\/+CdVyEzsoYOLw6rMPXl1FixKvqek70hK351loW5KAJfDaaXHq5BVjLhz2uH8nTWGyLK\\\\\\\\\\\\\\\/9tV16ajQyUVoZPw44F9apESiWklPIg\\\\\\\\\\\\\\\/Nw4aUqH03kRPW05m+ybIXAb4mIavUcrw4i2CjSYqWSEpShXLPvZIUwypbTw+4UuJvcJbqFEcVrYAB6aUMFaYtvr3u1R0eCeH9DPKX44kK4wOhiakYV6fYQy7oo+3SkmfhE9Lg636LD0xgzcX4Q8k2VLjk7ZcI1ySLr6f\\\\\\\\\\\\\\\/9XbszYwVfb5Gv\\\\\\\\\\\\\\\/GV9v7zaMUdFT8l7WySdw4VdnRb8P+yrezfcYAdlgB95m3ILHAOz9aR+\\\\\\\\\\\\\\\/cPWOnbI5uaGORZpTSExno8EkU+UiNe\\\\\\\\\\\\\\\/mFn17bKjVZgDxh1qDITWqdfZDjvfSGZ0j1yOHO2h3IuMJtxiZ\\\\\\\\\\\\\\\/dN0r\\\\\\\\\\\\\\\/V+X2eI5Z6r0SXIdXW3rOxWEjs4hX+IdLnNw0FQ3jIuWew0LXD2Syd5FYdHfg8M0z1nU9th6CUBHwPiVLujI\\\\\\\\\\\\\\\/aCehZ99vN0y0RC5mHEEQqeJjZcOvI17YMZAJ3xQbP6DJT6Wkjpmd9+hov0jFKpRcPD8ir7wNckIhcqyl0c57fbAhEP0cLTMuCLH+HBL\\\\\\\\\\\\\\\/f0e+3i48wIDgajo8yc\\\\\\\\\\\\\\\/PJKMxXAtqymhD7ds+U\\\\\\\\\\\\\\\/OxDhkHNhwlNrs8x2rUJzyLwhjaUzKUSzsJSQ6A9xPJ4Rg3yN5oSJdmtdbGqBRIV9WAgypqTb4wuuXLYGudYycxjHsMAEfLN0mhzZKtLusWXvn5nc4xb54IDaZqVUdtzsdP\\\\\\\\\\\\\\\/kp9BkArNnhQknitxDVRfrTOpB0t\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/7nj+bHslmIvK7vLEOWtK5Awco0HNnOT4w7SGjxjQW86B7TpAttG2R2BmDsSjmnukYfXqDZgTezb5gBAzt8oG7coy2h8gmYejisjv2hDugHpXGRvMEG8X0Jy3++0L767yXQmG2t6yMfcu4l6uti\\\\\\\\\\\\\\\/zVsUpVYosDyqruAX9BhGuR01AUmaW6ytzbYZRl7kG+xCob9+dnTPS45guVW5NTGNiOOgESLDnijVl+eb6\\\\\\\\\\\\\\\/q94Lthzf35K82Psn5AOOYjnfVDl1HjUQzttPDCE9d\\\\\\\\\\\\\\\/UiMHJacHJn\\\\\\\\\\\\\\\/4l4U08daKQZTNRFqaM12dMOCsVD2eheDIQm3FEPD0+bGhKvVtoVqLY5k9BuGvPNI+xCZy7s80adg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SHUcj+fBr6oEQfks\\\\\\\\\\\\\\\/V9WCA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229919bb47ce11d850fb923e15e193f77392a04327760817fa60dc6c1b2fcce296\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e005704.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e005704.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005704\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005704\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005704\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}