{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022xdJl9O+\\\\\\\\\\\\\\\/0DVDoKyTN1+dQv5JOwRibT9CU7buWZTOy0eLUGpLb1RXQQ690Or1claQHYI6fdZYpGTj3UWNnguzSciOgXVXxfpoJCE2eLR+TqLbQf8UmGAC7sXd+t9RVErh4Lpurtqe2zfsjmwlQTDzDvd0ap73ihIqxHON2DWlLRvcTY4fw9+gBZHEOlrSHqJe7GoYNmDoACaOTdBG81DjWSNhyoDiDFi01jSC97pIo5mVX\\\\\\\\\\\\\\\/QHfWuFZ+k+Wmvev9LOLZIKUHCYymRlgTPj24Y6jEYWeNWOdcvEUAX67A3mtcu3bYZ0JnAQdZZaKXlNq+G741Zb1Zf\\\\\\\\\\\\\\\/kBveVXliQy+r6hlKuFyk9JjNfm4e8tX7SwJ9R6JJp9DA0+cIa6Rb5S5X6Hl6shYAU2trv9PY+\\\\\\\\\\\\\\\/xFr53N+zETgE2vh23nf+Cuu5JZyyh4Ub5rK7yCKTF8sm6zo5q0cW8h0neC21v4dwIJW270kjZSGwkcQgQ4XAqOGst419hsDR8nOgxsqfbCH8eLYqRZMPoZUpq+kZ\\\\\\\\\\\\\\\/xj5sHqbcQNZIEJw\\\\\\\\\\\\\\\/l+vHg7rsN\\\\\\\\\\\\\\\/QBruIZo666zYUCw8WwqgkfSt5NDcf8dLmAm8Ko5VuvP7OtMdCwQgKsvQXTakAtaMiCegEqNRTrE8PnG2Ps1R7YV3GbxpOmmpsCINxn3X+vJ7cE9\\\\\\\\\\\\\\\/f+6Efp5O3f+EtD70eON\\\\\\\\\\\\\\\/RWcr51dCI8k7Ok+vV2747vC7\\\\\\\\\\\\\\\/v0jiK1uELnx0Eh9uEdW2f4p24xTU8HIOvJWilAZvFOXEAThGCYWkTNRCfyabUIm9Sn\\\\\\\\\\\\\\\/gZx4IouV4T4Ytllo42+75d6WFfnidUqBtismxosVSi2rualOVbw6wTU\\\\\\\\\\\\\\\/GVWognMK3jfZqjrb0\\\\\\\\\\\\\\\/l6hDKkT7mxqXJAKKZ1GZAWUr8K38OFS57DrUPwHmgysJ+wRVf1ZgyLerObyS2GAV3LKA2Pt8SnYsQ+Vjgx4\\\\\\\\\\\\\\\/64buzbIF6oDffawT9SCiPuR2N1eqQNDp+XFYYfelsxNwznvAPlHMq7BbHjS7j05QF10MUnYjB8q33QyNiXeWR8nP+kvqqhpMg7nfRSQWfgP8Jdwkffrr\\\\\\\\\\\\\\\/1JgcI5BAc127ZFt6RYpPleauaE2E9+m12y6DVpYLt3uUexzcrh7rYm0vb3oAISvvuA+K6R\\\\\\\\\\\\\\\/yBhgdve+5bnk7QN3kQ2uPL2xMlLvZ0xqpN0biMgGtNb2pyhmkwU4uQRY80Cel0WiTcgxZALrIiqxKaaCnPab3W82wbSaWI3tUT6Zg2O1ZluObQRKkBUFXQFP3L4olpRzq0MT+Fv1eJofDMjr7vbjqWwfDvGQB17mUJVxW4hq32jViBh5bdLddpBTjn49X\\\\\\\\\\\\\\\/qNkGwm0UQ2idAL7GXtRIUs7YvYIP5EPsu6Np4IsMAsQYzu8V0Tsi9TXsFTLcal+9jXP7Vl7+XAvAgdu\\\\\\\\\\\\\\\/z+JWbQfgca78Q2hE6jTWtynSRYlzUF4xNd0Lf8dO87fE6Ca3msO8D8QD5osWubZcyFBnlvsQcBgOag0OjLeoowVJqEOvOtrU\\\\\\\\\\\\\\\/hEI2ez1GvzxWOQ3PxYTmQxRRAjrVpI0zrgBZ+0Rlt3RzDBTttIurmOfDVQbLUDPd3TXVe5oTlafzbzsych\\\\\\\\\\\\\\\/Kxfm798zSmJrIQdfUPlC\\\\\\\\\\\\\\\/Ei4Sa4WO3LNa2YzYXti2mDXakm\\\\\\\\\\\\\\\/nXFH9bjpxI2xTAaUghEx06Akb227EPtkmKiFP3IsVbOvXN844umD6J1Bu8Jx3XwrkPtmCPIgv6PSkvRJ2noRvUrVVk3VkisZdLgDpXCrQOTmXo6W95iZBqxqR+bLOEwjb5CzE76ASu+GDyhSa3kk\\\\\\\\\\\\\\\/xhNw\\\\\\\\\\\\\\\/pVrY64yYGCMt7ngYi2lp4Yz7Dfetb5xoMe9zSGbWxJAGpAD3h9n9uAko3QAqu+VG\\\\\\\\\\\\\\\/ROnXuvqAxvTeXRcl4Vofayy8GjSNeHOe6brIQLxeCMEmwoRS8oBi6huQ\\\\\\\\\\\\\\\/aa81kzHDkb1jIOLcuJkoC7wm76XSSEbOebI\\\\\\\\\\\\\\\/aZzKrAwFsX7qELU10FcsT\\\\\\\\\\\\\\\/KlI6QWXmTs4EajsMKJ593ffu3lodSPTwc7HcZMlhjY22PKRPpD6i2OWyYMyklnkGI1yCbLCty5cZazJjyY\\\\\\\\\\\\\\\/R79TJCM8lpqi94zAXd7KomK4LmrGOPydFnikVQ5jVADRguFSBJRC3uBmhDPPna8vm0oTy0m18pSOoZUu8\\\\\\\\\\\\\\\/UFhEDazi0\\\\\\\\\\\\\\\/6lwOJFSIpz7PhAqREcQNkiQHW9717Adi1ehZ4Ix9KnCIyMDDdN+XKltFbszoWyIWihg+UBCsoRy6qAxHpvlpVeEjTYx0y\\\\\\\\\\\\\\\/LDdXcPV7Mq8YazM\\\\\\\\\\\\\\\/ehab6k3W1oYEtlq6\\\\\\\\\\\\\\\/UIRRjeVpPpBBc0wv55v1kyMGFHMRSlyMaN8TRjyDgSy7uTASVpuzNHF624aKsZqs+MniwZB0eHwDP6VWc4bFjEZiUXAyw27O7SjO9eJWyhsIMw4vutzxNg\\\\\\\\\\\\\\\/TttkjfbnGMMTFetM2afO1uyurm2M61BC5PoX9riRaRkSw6QSarkK+TKJqz+3joKooEXz3+RwW3xVk3coW3FujeqfPynm4HBgV6QljCp33LVI5xfaUJn+VP9eOh8nFmfgYahESBYSS0H9wDHKGFsAZdrvczaeEtXddIPK0kpVwmTOqugjThZC2IQM4\\\\\\\\\\\\\\\/lBugurfXKU5POyzEKFmG4C70rgQ5lCYJGzZPJKwDs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022a0+ZB9F9jV\\\\\\\\\\\\\\\/BQ4u7tcpRzA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d001acb42b2e13a587d102686c428c87b5b2981ce6a54ddb573c79695a8a894b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e003783corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e003783corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/11\\\/e003783corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003783corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003783corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003783corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}