{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022chmntGvex\\\\\\\\\\\\\\\/32OoMhxQaGv+hytoJFIxt5tN8u3F4dat\\\\\\\\\\\\\\\/LAxJyhdyKcKxbYqArIqncVBwrTTo5FjP4iLy3cd1g\\\\\\\\\\\\\\\/KuhEE+afUoZzJe\\\\\\\\\\\\\\\/WhCiAA4BARRE48WYrp7LZcxh0\\\\\\\\\\\\\\\/mGDiDEEbYaVyELNv7J6eXOu1erlbW7+XE1Urub2LMadijHPHvp9ARP0bnj5V+TK7cwwh0IChQDUgx4DFBm+5H+HV7KAj2GglHUR1TsQ+a4wVNgdG0F+5hsKq0fXW6UEsMzsFLYNVmP4yC3Y2Hf1\\\\\\\\\\\\\\\/RF4RujbEEh86f1uytUzIJZmxCixTpoJ8TgA\\\\\\\\\\\\\\\/p5Vmohtk5vDrdFdNA6G+372J4e\\\\\\\\\\\\\\\/ZdNmcg50pTbPwx6rj0EtrjuZYCv33cIopFrgl25c3wAemR8wrzAw63+I3YLq\\\\\\\\\\\\\\\/k85zi4bdOoLWZblOo1oqTiGPMqvWHoueesGGLvTXWvO7T2dZIJwjEB1piStnalT8RRLvWgvjNAho8CZNg\\\\\\\\\\\\\\\/Nna+CL2REqvSvnlnpMs+SnHGObUJAzzbRAMthObDX9mi5BWgQHhTnUhBtuXdf6y\\\\\\\\\\\\\\\/y0GBnX66VsWkltykUbnrxzI3PrGdi8wVICNljSFQr+WrPcNIppm0GQh3q5qKJExmAorou2zWbxbK8edMxTq3oJ0\\\\\\\\\\\\\\\/3FjUZjyWQ+hb9VGrG2X9Gwt3fwzH\\\\\\\\\\\\\\\/Y32QSs7eJUdxCLTxb7Xa9Wwm318UI0VrgrDQRB28VxSNk5D3X1J1X3V5\\\\\\\\\\\\\\\/wiABsgqCOUiaZTTHuroN3PDTBKtlOgHJytKI3S7N7HNXZPAZVwB5SUuxRVtA1zKf\\\\\\\\\\\\\\\/gxz2\\\\\\\\\\\\\\\/KwCQvwgyDSVeVS9wYV21ZEw9noelSO8Ghe6PCmuIxgjviyGOUrUSfJIzTEW5Chpa3GAKvfVcA8Cpsr3dNuGC99f6SPbnvZO82+LOwkHD6p3CNHkFUgedHz3nQJpWuVFCILijqD5y6ykT3L1y5FpGlZSognW3aFyXf4ywlWxQOQ5OFWb\\\\\\\\\\\\\\\/Wq8iUkkWD1tFckrsAa+yROKCZFGt7o+d2B+LIbHkzwmQrZD4ugzN1F31cKFq2JLGMTe68pWbkTkM+buODUnuPNVPRJ+oPdE2uzHhGI5DE1bUf4Ha4QRxJFsDQYsUOUCBvN4KYitXQMGBtxh0jmM1shGmS\\\\\\\\\\\\\\\/mC4vHkUrV7qlqNFqiybc\\\\\\\\\\\\\\\/aosndrUOfGKHKeIrs5A1q8s1FKPbiYnUKcJXf1D\\\\\\\\\\\\\\\/AvXS19cNSMowIRjSx5bfe2t2Ym5Ci+XOXRPropfUEoJxwgjQg\\\\\\\\\\\\\\\/ZVXfICe+874V2+tfXE3hMrH4lp6wWmFkeR4jtB+gMT6aLTvd3uSCPdDcYzY+6YMVRCI9OrizIIgJELo3oF4Mog1F\\\\\\\\\\\\\\\/2iIuS6MyUXSNbcgn+U7ekLF5ebieX3wxbqcutMSMFyzCavGgVHR2PRUazv2oSJx+x7QFiIhVWwQD+lQTCBmdtGB3XmKGYRgMDfjKGSbsTZZZxIL7M20SdHZb1ekM2zN4gnr4BMO4\\\\\\\\\\\\\\\/pqdeMGUdo9sndFEOy05Qf7i5QNQ8AwkUGs4z39MldaDpAfk9n5nKXnalfNFZhwz4bweKfo64CniTmQ16U57wEgu\\\\\\\\\\\\\\\/tKydbnqq1vUaKcsTwLmdf9vDuolKf9ZC1hTMHK2gpBZAOae\\\\\\\\\\\\\\\/tMIiB7h3eFP3x3kN\\\\\\\\\\\\\\\/R0cX\\\\\\\\\\\\\\\/eXkX4uhx8ZFcRL1wcFCT1xj0rjZr6y\\\\\\\\\\\\\\\/q8+l\\\\\\\\\\\\\\\/CdZa0vBK1mYyPyjcpTVHjTAzmlmKtzAmFCLMEi1V\\\\\\\\\\\\\\\/jgnlaKDo7lhE4DHj\\\\\\\\\\\\\\\/EzcOQ6qcVFm7OIdJna6GU3DWKb7izzuAdcuOZ4enclJwjtVw7vyYcJSjFUxhnZ5G6ICLaIcFvcNhjoB3TKEkRfrtJniNaLa8KPGvYBQXwS4dD7BTstW1aSS2crnjLwXkxdMEVpVfzWwuyhaXZa6mFvSP\\\\\\\\\\\\\\\/icrQO2TXdnjFvEkvUU9wjyQnKxMainRXoCLE8brBHt8esALH39zb04b3a6uYvcZ7MxgLjUFDzgYU8kXNSgP0I4++Xm9HlkoXayRaBRqNiIxsuIaYIJirr0b2N+8JFlKb9wimZf7Ut5107rn\\\\\\\\\\\\\\\/YMbO\\\\\\\\\\\\\\\/1Tp6BtHgXf\\\\\\\\\\\\\\\/myR6LvZSwc6od7eIJZXa5xGnE9SkxJlHo0l5mzxYn+xv46puhpiADJUoDB9jAOGSfKm8nEbN3uEGOsoIsBpgVD5dgGMOEK0lLVXsmSMqk74A0VxPiovDwzRPA0mcfxt46ADJ+ug2Kj6CWb68M8jlkD2HZhBf8z4OjvHiOr1\\\\\\\\\\\\\\\/RFwUtZCN\\\\\\\\\\\\\\\/T7x4TO2U\\\\\\\\\\\\\\\/cVSwPAQ4dDfMSoY9XThwIaJj+UTOzjrnc5VOYUGZN4FMrhMTVVqYx\\\\\\\\\\\\\\\/81HYeBl7DOvxbPo1KxgVGl7ydCq3kfpKo2SMOFN24YgVpJTVGSkzERFh5pmIN3vy+gDgA3XGZNgNNwfg4aunyhki9\\\\\\\\\\\\\\\/uieWroDXEvvGqCB+6vcN2wcjO284EwQnGo\\\\\\\\\\\\\\\/4QR2OZ8mz1UGGGVCyVOUMIkGgMReSY6Kkj6bTf4iF0bCLFcGdpULVwDVjeyj7rHMQA2EkeYkYaxPzKZJ6Vbvc89dBTbhPK2G5czc2SqLY11nA4m+ldnlijFacDuGJGikGCOxYYVJBoYQUMKMMLB9xyXWOHYud2Frmp+P+aBAxN03qllLKEWXyt1T7189th97G253FkOe\\\\\\\\\\\\\\\/S0eTsJ04oYtRerG+4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ukWjbf5Uj7r5pL2m5AGQCw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002234bb49d7a8b9a672903184a6798f776465d7cc2df724a1233ad5522d7efa741e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e005575.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e005575.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005575\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005575\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005575\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}