{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022w\\\\\\\\\\\\\\\/l65bjZQSUX+GmXyrI1ODqLnP11EvLb2BVn3za1GDBUfkriURlhBD0t4C9qtnAccQoKqsj9j8iMFuRoFMgxfrKlLz9UwL1WNcjrH5T2qcBnlytlJ9W5RtWDxei4fNaqgZdLJ2pOhbJORxcp6fdpZch5QpF0BxcEYTfug6yemXkbtd93eg0uDMUfvEHB7wzUBbmRwmA9Qh7uKD6aXPFO\\\\\\\\\\\\\\\/7oekuXa6ocnWpuhULIcSWBX7VOh9T1kE1NyQs4lvcQw+mk7a1qirqX1yQnXzCKPkZE\\\\\\\\\\\\\\\/DTRMVJG8G9uGGpPTm\\\\\\\\\\\\\\\/vqgii1AlbZfe7nXREpsxrFg5XGmK9oF1uetjz4PK366jgyfRVSdH1o+0wf8KCsTeye5LxSuU3sOrJ6nOYmv5oe8I+bN8srAeeO5kLsjYW2CLl66OkquVHVi34i1ogPt5B5n9Bm0fetdXpRMj8UeKUZD7I0Tvmmc+xlUCVPIVP\\\\\\\\\\\\\\\/kD8SoSuqUI3eL2LfBDP17NK3rjzVN2f2D4Qs3P2d48efdTZ44YUFXeqjx1xIHH2KO2BldDMQKzkkHLEDup5ObuLDYq0RonfzjBJcSzqF5m2nec0aYX5P6jtV+dqdRBwgPEW44XWOPD4T0vY+91c0bbhP8cUoU2ZQx2zPQjeUyI047qW6qYmIE3UczS6Zy0fz0m2nTf1z6cktnvTEQy+3hx\\\\\\\\\\\\\\\/lDlfWR1pjrv0niyNVchTMyHRHCwdQkOazFJm6OnFJCoKLjgmLSVqdm0gh\\\\\\\\\\\\\\\/m2iaLGqr2VePuFkeeUQeT11OS13szpWjkIiH03HzgImWnSk2hfHxLDLsm0ENMUtHZ4HbK1WqmUJlwkTBruCuKraWLstVBV+wqddt8Rf55Si8C3LlWdwF3ZUcEXyEFWv0sDCApEoqxOWip7GcnOvxbkHGjXgGBkO6+2ePDCBvjoRDpwY6DHmfeNendGjAOREbAjmln+X6gxpC8qoXmFklV+4eB2f\\\\\\\\\\\\\\\/jA5DTzBFNxq4ba9Yg0gwDB+sV10AAZzNAs7l1GcB5B7i7pydwt3p92FBP3XDdP4kaxSRhxbP9fFUqR7Cya2b9hWmv32OuOVYe\\\\\\\\\\\\\\\/kAJepNZdjBYNLiGpVGfoYFMgg2swhf7ozQd56WD3lmzEnwCUUIQ3gr+nkdkxBSw+hqCjMtnU34Lg1Ulqo5e4SHyAIEEzuMteb3AOsFbXwq21gBMDzs8Hx9etb7XIijpbnbFxVhNTOnj\\\\\\\\\\\\\\\/o7i99NjSAnuOqlSve5nUhFO4jbP3Tr\\\\\\\\\\\\\\\/tcXnGWw6WekvfJr8oLWlZbChJpfqanU3uZi7q1SGLf6Wu9AyHKqQsIIeaCRgSrdI4d\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/L2J5TcN0x71Io8fdCVmxoeNk\\\\\\\\\\\\\\\/CAtAe9oRwq3wOBdvyHaHmjMvxGHjUJhIM+l59Glowk1YmKfJYW6feon\\\\\\\\\\\\\\\/cyVHUp8kqGZyxwISI2ONbWvDB0MI3MgG3zLTRzEs7QkrLgRaSnJwCstG0oOHWDRt30mCVcE5xyEGULKsrrKyFFv6908ycAemk4rebnWxO4GtaZAl1enie9vpS058cSmznMjrcYT8WuP6mAu7RIRbqXpVOXIqV5aATZNy82S0sqxr7m16GyLrbrpNOYkd4NfL4vBzdHVloGGi8rFdkNeEkPJnaNL6HFhU+JRyX\\\\\\\\\\\\\\\/1aJtStd7KVsflIWuxm67LOGv9iZ8BHDDm3sSKJhLa0ggIMgv9UUNYHydDEpu+H\\\\\\\\\\\\\\\/1qooYeuneuLP8fB8FmhANirO1l9QEoiKF+\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+pnC3rRq2jiyou5VWid0cYb4+c3b1u3+h\\\\\\\\\\\\\\\/WcTPzHD7DmwV338pEUIBnc\\\\\\\\\\\\\\\/9nF6OpcgqnEZuQzROyk2UPJHyWlcfU52p5hre6FXmRYS\\\\\\\\\\\\\\\/urn3GXElcbobV7N+aBrMtW1iuMqIMf123loVWrT8d+2o4FEeIrpy3JvwFyqLLKJqiM61dVIJ5HodMvH5vsPf+6Ghqs0Sp7nqE++5ym4Vj9xpChoP74UDrBIBxeWpbRIGJhajM1CxU3obk5JcWcyphoW0dxKmSsTsZUG0qn12OwrAgyvGd9BTcit89qCOQNErVF+VA4t7yU376IqvGwg1jlJ25LgYgUic83DeX5bYWFOqhzovJmi0BcUPV8uslqJwU23BYRApjXvoXOgu9zelwy0Lj3WsCtFc1Y\\\\\\\\\\\\\\\/LIUAWPN3p86giaBZ0wzPQfk3ALlFEQzOcZPKTc+Qv0vryfdL1LI8cCwlebN4yL4HZiWZ6itZ1Yvtz79xnybMQl1eGuhMusnfythCTOuKtWQsm\\\\\\\\\\\\\\\/lxYMKEAoyK3zDyCGJYSXPxTnr9BDHc\\\\\\\\\\\\\\\/JWX91tm3BieDuguj3K\\\\\\\\\\\\\\\/t58GMvQwTovpN3fQpoWkRwfXmVxTPOITSl7FmoX8Sd7lDOfTH60HHf7t6TtKC8d9Lkj6mc9wf5zky9kbI6liArzC6JBAe+T8+b748dM2hlpLma081lmXkPuUO9fXaIt9UEpu3Trn3iiqH64jnMzUXrFb1k5UuvU3PDXb38z2mrEAjiRLX8FH9mIQPSjIdnX90MvUC0\\\\\\\\\\\\\\\/etk14FrTlNCVMp0RTNs2uQfx2WOwC4fgDJCJqmYZrAwrEx+ZyaaIrirfVS6or1RZkF26hrqClwJya1A4GBcApk5dTqykCYlVGg2\\\\\\\\\\\\\\\/GqQcUMlbrJoEBGdoX2TESVfo5Ilu0PenTOMleQYJ5Qc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wnhY0jJAdWBsqKbvM4y2KA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c52dbf5027af8b319f1be931b9bb211998e4d467ea3b98fe1f4a6d3cd390e03e\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e005577.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e005577.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005577\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005577\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005577\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}