{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022eeV3i1HjdcePzgXW1ISPVSwi3A30kvJ4Tx86+e+tqM8qcn9wjwfyUaCri8coIXQ+K8zJwHjuOeTL9jldKkfpnzEcb4yqC46XlaJWxC7yDL4Rab4s5K+KTQF7KCeIgJMWMilPnh9bwkIg\\\\\\\\\\\\\\\/5bjcGByWoqnV8hYblsawmeJFch+VHvUXK1BtS0oqlWzF+mB090wslvzXrn6UzUv1VACiNLBHBWq0AJL09PCeum\\\\\\\\\\\\\\\/JhETUTbehhX0dcHIdlToBlzSVzImKCoiNiU6MODjb8rBY4mU3968aGviHSkCBJCXg1sfpr7fz77MzjY7Nvr+7adjR2429OCWM\\\\\\\\\\\\\\\/o6U9jJDl0Vilvb571e1mvqEYlBhMTZqrsQA1pRbVrsWiYk\\\\\\\\\\\\\\\/506dRHRU0yx5b8UXOL23t2LrrtwvmCuLm8nQjk67rETkmkxlxXV1T1c5CVmM5pEZoHbXnq+WYSibreBlKxxq\\\\\\\\\\\\\\\/ihG1WqpgVStmWXYjlKqLy1TtuBKpA+XCSwK5REX+P1MDc\\\\\\\\\\\\\\\/ODg\\\\\\\\\\\\\\\/USkq+8wnvMTFcYgaT\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Fsw3Imf0PbNlFg+5nh9q\\\\\\\\\\\\\\\/AYBDisM6arCF0m2FgfE188DHI0g9Wvgrdl1vZelAQk\\\\\\\\\\\\\\\/i6CpfgnLh5kmc9todlq8gS1BpOJh+tYK7tWJ3u5p1cYCVW\\\\\\\\\\\\\\\/mTUjygtqgEGcBZODK3l2qNbKLzcYE2SMU3abxL+V\\\\\\\\\\\\\\\/MjHR8se8n3wfvRemsq0eZCpNZH8ccbxyO1qy381fVaDi\\\\\\\\\\\\\\\/5KGZ4oXRMGGAibp0cm665Gywla5In2BkglbNZnW6b6oZVH2f+BuRVs42Cs5PK81vBRhMw+wcWKCTVohoZOs4YeGhQwQKIFyPFo8hy1vpwvtP4krPhmQZGsr6luK\\\\\\\\\\\\\\\/VCkhBRohNqjLZ626O4tA4RRCEx6VQq5\\\\\\\\\\\\\\\/dkix4nSW10e6Kjl7ofngbPE\\\\\\\\\\\\\\\/WvmyVfYlA97LgeII6dBTcO9LyDXEuQPdY6DCtWPVSDADqCMyZtzuRqgXYpeQfMp50l1u+qdpAqlbzRi1gGF1G4NRleG7Ru4Vxqy+CHPzKlqmq8o3cmkLh40LFfvhyGB6FJeavcR7wo7ZU66mXhrs9Ct0NVcAdCRhwJj5Je0QCFbycm0FIL8ELWco8aeSrf0MTxC7McQU1h05iz4DtaSAy68NzwJFpJA8tIEc86q8YewvXbMywj1rhe0YZ2RgYw34sEjK7h8w9KoFfIFImzLJp8zeR8efNRxoflfU4P7ZVBSqNKQb\\\\\\\\\\\\\\\/IZEdwJSSV9K5Sh9ZOPWhRzMUxI9xEedoecx+cjBtVtUCrJWcARy60XSw0WkBdV0qfJRQF8K7QSoXKQjrLqsdmR+60CliCYUxVdfP07rUSkWzwCw6GyV4ghdzDFXSwBwENogfyWLJeOFn2V2lSFabDpM5ax0JDAhgjL5DaqkS6wDwH7OqylHl0VB2+MMRujnDocJdsRcZm4i6cvrNVkRiBGqVuakI83lM7A+a8OhFhSBwIzOK5kwm9XcIIkkmPp4biTzHwE9k1fo064MnoWQdGBcKoF1R7P7m92Np5f3kVHMAHdWQCveetTEBhI6OAHewLyXjsunnXi9TqI9dvfEKzbGneCGenonR560PXkK6tndwZcuHIbXGkCBOwhT\\\\\\\\\\\\\\\/fiongioxg0n32Bqq83r1bIPVuP71ztg22ay63CYhZLrs5h9e42\\\\\\\\\\\\\\\/ph72Xs8icOuMNDDlFUpYrlrt\\\\\\\\\\\\\\\/lK0Ihn\\\\\\\\\\\\\\\/76cAAqslFeSQWYfsEerRR3\\\\\\\\\\\\\\\/6HONv6Z+GkJsTEroG1UgwGU+GLgSR0Q0C+nVNmnZDWOq2Vwpw0UHmwRf\\\\\\\\\\\\\\\/dbkvwxKKStBV71OCZdtDDth0Fcq9dVG48a6iEIV5rzCfDclynCk3Y6\\\\\\\\\\\\\\\/y4lb6dIo3YXC211gEAdOm6QbwjQ9Dz5NJ+rcDPzfTk4n8ECau3c0RQOuTWnrrO+\\\\\\\\\\\\\\\/CXeFp+VchLaXw6acfGKZJUQ9+\\\\\\\\\\\\\\\/VNwC\\\\\\\\\\\\\\\/Ip6mtid+5aQiyCpLIIsHq4eQTWDCXZruE4TvgFG0+a8eDSWwY6VfURNTzMY5\\\\\\\\\\\\\\\/T9dpb7s0\\\\\\\\\\\\\\\/Ygpytgynk0dkn8hpMcpHMMa+lvlVjQOt9jPCpYdnZBRy51Kub7bOb0BVF221aEIx4uEG1eQm5Xe4KqHP7wxKHqpZ9+kJOFR\\\\\\\\\\\\\\\/ZkX5Xcn9HJXMi+Mxb\\\\\\\\\\\\\\\/UcKTkFsIMcLepcn9rOlEaCB8imzszXxqoJzGEfXyFPFbTNzz8Q7nJmDT4eHnk7D2iFOJ0TYHt8PeZF9Rcp2MhgoZuhdsZew+QKF8shEGyz7TgDuzT0T4WodegxvyTkfhQqPXyJGaXtOLy6Z6HTjtbE9GPLzzN6MKCr0ImNNY6pt3gAVlDAmz5NbCGHwRclhehbhQ9S9rEUVyspQG3ZC6qaWSyXw6Mbk9I8CsyIHRbXy4Bgcc6qs5NcvhgD6gAhoYyaKfa2e0qHN3c2AhVF2Rafh2Cldm2c\\\\\\\\\\\\\\\/oS1xlmfXVPOW6jUNKEUxrqQKEicw4UnT4uknagkybDVecUvowaAO+OpIIqU01PqCmFTU3+xIOl6s0GyhyKQKb2ZqK08YbPacfavSY7hI+I5IDsQDTMipm6vYH7AV5G4gVTn7qMUYU4AH2YXyysfKsaee4M4vedcTQgkx11OKEj2aZbpxhn\\\\\\\\\\\\\\\/0Mqa\\\\\\\\\\\\\\\/IMDSdIqKO0q3TgBBc0gq+7YfNjQa8C\\\\\\\\\\\\\\\/7+0G1SsAvqhP+Lo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MiSIe5uYOaZsoUn5mqTBdA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222bb5fdd6c6ea73b8abe8c531fdba6af8ffdf8e64e86175d8c5324198ee08bae5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/11\\\/e005241.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/11\\\/e005241.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005241\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005241\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005241\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}