{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qh\\\\\\\\\\\\\\\/r0ZKt8VeEZTkbn7ukrjidjDg8HEmOyU1Vcx4iMInlPl\\\\\\\\\\\\\\\/HS+alnXEVMsY2yYGNBMyfrA03wEGgMpHbYWu33wjRkUUUFOhYaspMoxyok8q7EjrKiRqibBNNltum3sUornNqjw8tN5SkwDiuk\\\\\\\\\\\\\\\/0ia7SNcC1u\\\\\\\\\\\\\\\/tE5ldcK03S6XVLBdrZ2xBoU5XCpXXMto1U+XxxVUIbjkvaHnfmuooQcPQNexjyCKdRnNVo74AeX\\\\\\\\\\\\\\\/kl6gfnUi3ZqtQBwukMat5PzSArpRMTP1cGTpYpkquVfVTY8iuDLzCD249bn+Vb69YlTvu42cYfkaNDGYh0k7LeFWw0S2VW2\\\\\\\\\\\\\\\/UWzwVQ+231yMhI1CoVN6stGi2fIMcianvTcpq0NUmUlYe3InHjgERUQLwWAIZOSb57+004cJK6b0H3RvWrGIInrkppI2m2KfJuSbJ1NE4ezU1mqHHE+wFGLlS4o9xkfavmIK1rUuKH1xPrpquxXqbxiDdfhWGkccysaroNXsbdF2Iugxn+dqEPuCLWFv9alYwczGnaW3aJYn8uSHjpHJSSXQhh81asj1wZHAyCeLR\\\\\\\\\\\\\\\/fcP4wpovgbexTUWB6vLwnMtz0ADZ3gZoLD9wUMCOsxbq0uDGI0Ihqzn6+hBn7cWBQ+Tf311UrE3rXnFoHyLNtZmMJHe10VyJXBf6qOd790Mv3lW81\\\\\\\\\\\\\\\/1vmD9uNMV0l4gRvcUPFFxTpnI4lLv638NumjWOUeXTSekcfwa9SYcqXpy3YpmuNJIjtJLsqnjZ50WuQl2\\\\\\\\\\\\\\\/UZ6tYVZUvvu1B8Q15EMU0rnzDnkRY83pKz9znfrjbj45jFZ8rj59Z+RrhiGFTAeSmaxxB3Dvsdtma8l4hidysg2R+nqPNzuWLP40q+DcxWU9y4JlZFgMf7euJgeD86f4D3lbmrk9g2NTpM3MeS29sChjLZMb1LL4evuEuWaEnWS\\\\\\\\\\\\\\\/DZypFgpNlvJNharN9rYaAMoQAZMFFFojiX9rbq2ZRGobSdhjvNGD8fkAB7x2+FiaTZckLOuug03oJRMnbPKDwUKChHmEGz15U5Kg0diNOtaStlHHc+sAyP4234O9AjnNkMr0ohFjPfLYPjS5\\\\\\\\\\\\\\\/rikIP59LefNvYKWtf94BeNcxaB0dF6fXhMU9QLFKAhz8ThU0ubRVP8DjjpgloiSZnn91dvrzmlACCGQcp8th39Bx\\\\\\\\\\\\\\\/vPuf8lBEdde1DMu3c98kn\\\\\\\\\\\\\\\/btDfaM3Op5XlgkDNETX\\\\\\\\\\\\\\\/Vdy390jsnMhT6R22d+bOD17pwUWZneLB2O89xzFZL3cnFj1smNHYGb\\\\\\\\\\\\\\\/ZDsNUvnkYC97ljMuC+cRLM62YcW2ys5lHnFuyqwPa2CqaAsX1GXV\\\\\\\\\\\\\\\/e7x\\\\\\\\\\\\\\\/SnUSf4uku3lFjBHM+HA6wbnnUmjZaCA9UxF5dRk7KrxFOCQyQXmFYa2H\\\\\\\\\\\\\\\/bP3wd96E9DYl9gg+coHReldHDiNm2qbnrqtlou1fcHyheIW8wBOr2GegC42W6FKqBopDm9A1ummhR\\\\\\\\\\\\\\\/RQukq91tEfINbWmCpHTSu2qnM3qvcA57VubHvg56b+lJsr2j6t57YYRB8zvFqQ2El5FoY26pUVU0vEVgAzyAslyDWb28vTcAOGGG28zORaavQ0Wtu1wH4Cm6oclRqjzvCt4xyacrkvpb4O\\\\\\\\\\\\\\\/hYJ2LcM7kV\\\\\\\\\\\\\\\/i4Dd93nTcDnS5iYxTP3A8y\\\\\\\\\\\\\\\/WuaxjLZ5FJhNMnDNMtN49\\\\\\\\\\\\\\\/LOkJgeN3Udll3d10hGDsowySYCITzIcBjQu6tUdc07s60qP3l9oQ+h+9UmxMnOEoyvnkeLO5rLFSbInwokgz6c5Z\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/2ud9phiHi1yoy5QUR9LTISBztamduMGoaGo\\\\\\\\\\\\\\\/tFIDEKhWqZntdNwK3fiyoLq9KTWeHOqc5YVoRUPaf1VwShlKTowRB89a38Ke86w6HdXVUMj63XEqBIm\\\\\\\\\\\\\\\/gMOxXJFMhjih\\\\\\\\\\\\\\\/MeyozuPfu+rqXw815z7kNqLKmaxA8StxeWWvtu3Fj96CMN\\\\\\\\\\\\\\\/jekf4fkfMXVAjNHZMzPEHyRreQuaKUSQB8QBZisKV\\\\\\\\\\\\\\\/qHSuPialzMLJ\\\\\\\\\\\\\\\/0MmAJRUa+ZXykkHKvo5X1v6RBmsWEj\\\\\\\\\\\\\\\/Rg3yCaBVaQepsLdb78o4LOMICmVT4St3wj2hPK+kL55RFmC9E6KLM7lA5WMse+Ri6ECQ28uvrvIs5bWqnFyagyVwSw8xVSzbzIdWG7Z1DGkZnNoMlJ\\\\\\\\\\\\\\\/hlx\\\\\\\\\\\\\\\/zRBh06U9OQQZq\\\\\\\\\\\\\\\/OcuAFPTcPF6ujBw7uTGJ3aZ0TnnKa+0wiqaoPoKgIloes7TA9WM6SuUfzp6dTAmkkksEDD3WYaBmj5J6fNi8d1qyFW+dMGuKGKFMK3WorTGVzkX1MSLvNiiYR2sA5SlXaqeuO26ussb6MQ0nYFKIq7CRLzf3yFXPd5c27eb2zX8IhpdsSVqZv4WEdcxxHN1zmcFzPmywthBZulbenqW9pH7oplHjV\\\\\\\\\\\\\\\/M5s44dOC55AIgGprKexzHesIa9AyyMw941ZWaEVSvp9URwvKALOL6kKea4cH4KcYn\\\\\\\\\\\\\\\/OrQ159oJ5o3tSBifooB8jdmxkyfqg3RwPQkpRpCbJdJMj\\\\\\\\\\\\\\\/DIXnqnVWE9q4jG4MrZZQs9HZVakwmlAS0StbfsCKUXV84SVH\\\\\\\\\\\\\\\/KYx972IBOyfq+EQsG3JENJSDlihITk5l1xhtjjUAvLzKwq79faa4GByFFrQAnFRVNue0TCF9GUzEyJgY3A=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wQFPodNjtUoL8pcNWvUqUg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222102d2f9ee3180366a1ff6eab09837a2916d463c4cc130ef6e768b1a0f9e2dc3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e005292.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e005292.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005292\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005292\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005292\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}