{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022CkUaGMFyOxfJSul0KzgJlM2fG3OGzBKn9aAFubHa2AwHVWrXkGHKVuZuf5xbxwPDnKG9xaujm8i5auZIw88dLO5z5zcajFMbQZ\\\\\\\\\\\\\\\/dXUVCcmXSf130tIpi3ayegO83TV9igLl7+cH4pgNny5jE587KSqKsoWaHEucHNbeGt\\\\\\\\\\\\\\\/OT3CSShi7l5\\\\\\\\\\\\\\\/Hzu47jlISTQckVVEhcVO9Bx7LGBGo4AXj2UaizruOhe+TVAfRcuhzxtopmC0\\\\\\\\\\\\\\\/LVyxmyuGIcKVDabV+Eric6w15muoH\\\\\\\\\\\\\\\/Jljh3FhnFTg\\\\\\\\\\\\\\\/mK\\\\\\\\\\\\\\\/qIbNu+x\\\\\\\\\\\\\\\/uNP5dtY9Ph4JJnKj2bmaIWZVjTvh14sR++8Kk9rOQjsV0RPZtfnPxgdi8prbVJGmrgH0pOpIs3Z\\\\\\\\\\\\\\\/L7tG6whQjmeUmy3nhNsr32Ezc4++6gxRMgDut7YYbHVLJh2reiR3T2ZexDRCPB4gFc66vaGRBmLEbtWNDCzD2GbSyCQT2HH2ai2zQ5NmXW5gGObNQeH\\\\\\\\\\\\\\\/mValYxiUkLJlEyVx1JBa0laUbkcBFUj7RQZKsECqwHH2B6A7E+iowPPYGd0lSjY6FH7Ueys\\\\\\\\\\\\\\\/nwPEydogGElbkf0KsUsJWb69lMnXW4jCIsocm2UQyKH5EU43sdxR3zs53gVj9mwqkSbsMgqP5gifrIu2gCxcF\\\\\\\\\\\\\\\/0yuBHs8LgXDbMQI67Sk1P2nOecrSxCo0M5EwjBxYJKm0lceg3rRXRc7+3IUGmCSvx2JfHMHdva5xbmv6MZ9Ey5XGtYp8LiBuu7uCwiUWUAdR33+1V6quc7LcLx8BIkrc+jxUAr\\\\\\\\\\\\\\\/HjDPvvWqaC6vER+lmEs1BXp8zzuqTCbzZtw3dlcecB6oQEcYziR9Nm3Id+KBif5yoWdyJgdcqrUKG4psTHPyVFRehM3qRdkBJqyWb7X9URLzbi86YLaB8cRFZV\\\\\\\\\\\\\\\/905wRmWWiwfxLxFiDhyXODcBXPVIA\\\\\\\\\\\\\\\/h9t0dyfmyPq5xXg+182RBywiot\\\\\\\\\\\\\\\/kvv8sNvBmjrP3uepl+Pyi78edlsf\\\\\\\\\\\\\\\/LNCubrx3iLGE8Tt668ErEZ3CHBz0jJ\\\\\\\\\\\\\\\/r0PPcjLHUta0JmN7yNk4xjxvGW8xd190tX4yQ8y2zlU5v8xrvjum2KqOBIeDNhzYwDTjw8fXCxxM9Jc34Ga7JD8EZ7n1OgGR72\\\\\\\\\\\\\\\/I1HTH9qYYohlVS9iEtDXNB2ITb\\\\\\\\\\\\\\\/yWFfTOptS9GMiAAyF7mDTlqbCg4IcgCHgBEFT22N+OHz3yh2E1cq7U2yvq7TY12MESmOpqZ1aZlqd\\\\\\\\\\\\\\\/SfpQCPZqwUiV5k0\\\\\\\\\\\\\\\/3SyXS1zI9GheVUoBAM9Ji+sSBMmQdDFg30EVQNkbhom4YBMPlxhymsRGX3RWADsTQI8WFPPY9sd0fdc7QPxMiTDDj9knbgH9Z60s2AiKZUzOffOkfVEE88UIrZ7H\\\\\\\\\\\\\\\/MCcGsLcTw618y\\\\\\\\\\\\\\\/txTa\\\\\\\\\\\\\\\/4N5drC510ZAfW5tUPBcYHZo660rtntyIdrBRBgJDN2rDwVZawvpJYrj0g\\\\\\\\\\\\\\\/ErXZbvZZch9cwyQViUnS0kQUNqaTcP1BQLB\\\\\\\\\\\\\\\/yZ+3FGGUzCX+l107eYzTQ63+vaoa4oHf7eoO\\\\\\\\\\\\\\\/TZ9waoCDS\\\\\\\\\\\\\\\/9T1FdHVftEsQJeRE8ZlmrscIu5XZSRLt0Ke\\\\\\\\\\\\\\\/G3QvxoP2RKfYLV8HxKq6JRWxhhTjpxhESQ1w5U6HfeLvYqcplosZBZz94ml+OuOOVkyX0odcSJ03aLkoJgWkODonmIeBlWv+YMbov4wnUyBkFvxmhlV7doJjhyqH0dlGlHpsg5nH1j9kNQr4hE3VQEntvwFDev1bB8wt99voY3XUzb1OZ8uy\\\\\\\\\\\\\\\/2iqCghrOx+Kw1YkfnqRL98\\\\\\\\\\\\\\\/83WHSGk9XvKyGG4AczVPP\\\\\\\\\\\\\\\/ciJZ+OK0LMPgF8h2tPlkzRPnIDOuF+1\\\\\\\\\\\\\\\/zo2t5ODO0ZQRxwgiMEzdLQKPoMXjYJk4\\\\\\\\\\\\\\\/SGo39WZsbUAXXWRpxYJBr2jpcgv8CCU9EbJVvtXuGU3BvJ8VVll4aAnOk9cP5PJGI5h0KcnuIVScRuJftRxs4XUWLpI7GWAjIA6uEktKQCERUR3wv94kJtpfCuaweEPrbG17Wjuy2xbEz10vBXyPkdpZkSqnt1RkyYYUhlEHid\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UchlLyB53XEVgbodG09tCalUZUYoJBYXBA2Ji1wEQJKv508J\\\\\\\\\\\\\\\/ncw7NgY+iX0E9lZBw1+lQ6CXxWA7N6uy73Ch88wOEuVZetnAWACwFgmt8nH\\\\\\\\\\\\\\\/plPOProU+0ruyfIexuRZ8yYc9bgCDWJyG4UlwcT9gYhMaqrmbyfESm2+MjGIos8+bFVy7ndrA1NUmpMYWqmTsqL+5Yjdfb8edd01DTUHvFtTJoLiXQjRmwYFkYrliB+iy0Pol7wKTSWfhiceFayWewJjM+9jYzLQDcfMsiDE\\\\\\\\\\\\\\\/RZwxwt6ek4ktrVyG\\\\\\\\\\\\\\\/yKjyGxB1a7N2SmT4oe1Kalgwm7iDf1JB0S0Q5ni0SqmqVAMzMwa2NnuA0JkR6RW\\\\\\\\\\\\\\\/rGd73SGnOWNpy7qN+ByqVkBuFUeTk3SnNbza5BKiNWTNpQWK\\\\\\\\\\\\\\\/mh1KUO7kpYFEYATRvU0BMuuwmylJulGdJQkm\\\\\\\\\\\\\\\/l5I7vph\\\\\\\\\\\\\\\/ozYiOX9anNtUpOhshQvGdCrONlNi5ndIOKKU44sg9cxhGbn82tqSddFtIWAEcuqy6wwWPHZnt+lWNp0bSvaXIuqVbfY5wpAzyL0\\\\\\\\\\\\\\\/BVYpTEZXbqYDU62B507ex1JSKUfyo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00220eAZfTmMZpdDqhpcciewzg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a52d746684ca2ca084d5795720baf8a514be7bf3d244cdebc09c3d5e6d094dcf\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e004600corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e004600corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/9\\\/e004600corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004600corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004600corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004600corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}