{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022P9YpW9W79KprU4lWE+jaOnj45kB7P60Jgdtle2DbbYHa0p3sp7aTS8FyoisMGFAUFTuj7PsgnFiCVOa8yYpy0SHCmxKLNK\\\\\\\\\\\\\\\/InjnWDc6qt+dJ22rx4A9MjmqPWkMW3MFkypZG3eoMndC3gjC70+xNnepjPoqPVmKE1omwCRlW6WVTO6PZ\\\\\\\\\\\\\\\/7HjnBh3w\\\\\\\\\\\\\\\/XpgsGaCYz25WD6Tfyg3Kk2rYPGQHnJoPkDchUYbJvKSlmpg4+aC+7VrGNBanJ5Jba9E6PPj9GCrBiDjzyNRdG50mOXi6zZY4MXHIRX5mQqJFjPUjfezI9WxxzdzUyURBuFIFm2BrOfjOY+JhBspZ\\\\\\\\\\\\\\\/IbAI59qgFKaj3FqBcANmZMoW1rp\\\\\\\\\\\\\\\/Nn6efM1ewWF4uaK\\\\\\\\\\\\\\\/ciTdETiSaDLGYpxnJz3oqvQLu76LvcjQ6gypgeUcSkhZ7FqgX0mvvR5tCsrI649ILU3FXQDq+ita8061ufFIO+zF+OKl75zUGyjsSUREJPLx2n+o27m2qwkkh\\\\\\\\\\\\\\\/20n+gxI\\\\\\\\\\\\\\\/M+GcRKp5HaF7SM+MH0xV1C1WYOyun4PVTah6oL\\\\\\\\\\\\\\\/xrUjX1ZKNxV\\\\\\\\\\\\\\\/c0ReZ4LSGonsfrGPpOBObhaL4C0Ykc146yIAhV18dqBciZh4jvQ6qJGwyexAnqAxarB20t+uoq\\\\\\\\\\\\\\\/AW7nutdHvtwlbDwdiWi9SJQ8jPnE0S3gAiajSvPgkgH13H9OVWJjBZH4fj0fjnSmm1QLkuZcfKqLCj\\\\\\\\\\\\\\\/mIXwimFqXMq6xH46XmfffmWwHRDu1XR0yVEKSKlXSnR+odYjL+Ky6zAFUmpc9fhCWwM2nWpNqftm2azpO7PabNRlfKYq+ukqMr92sVXWz2D7KB3sgEX6hd\\\\\\\\\\\\\\\/TJK4d1HeXgE4D0Uj\\\\\\\\\\\\\\\/TJSLzbEohKmBYP+R9SKQPsA\\\\\\\\\\\\\\\/ZNA6UsD3qb6oxVN4Qqin7X3ShHAWb3ujwzu3JLdzK3ZwmylYWoXG06MBMQk+TFhjRQ4okm2R44ngHed49rRyfy7LqvNz3ahDrGHUr340CiSbXJ1arAN4\\\\\\\\\\\\\\\/1a\\\\\\\\\\\\\\\/lKPybvdXr50bm\\\\\\\\\\\\\\\/cbPqYl0d0WxEh6uoam6nAt7ecYHxg4UoYJlCoxTPb1Myenj+SL\\\\\\\\\\\\\\\/XUGidIexLDpe+i0WcF8lRio6gRtbfyI2Z00sb5Bh3uTEsY0kAovOsrfbd1\\\\\\\\\\\\\\\/E5F5cCWLR7xTruBOFpSk0DpX0bbaX1GxHJ0Z22umdXl3O9QXB+SL7bYdgv6y4biJIsomuQjI2lNhInzUuptO3dzUuSgi1uiqTtg3UEqGajHBeRQ8w72XUIsqtHhtb4J+TFHA3rUb3l+wNBdHU94SenLVVaHvjEp8RP3+\\\\\\\\\\\\\\\/biUBzZ12LAA8XqWUBmm7KiQHRs\\\\\\\\\\\\\\\/UvERpbsREeh7YMFzPYdt\\\\\\\\\\\\\\\/bOWzPB+xOow3JrFEVg57FmSJenKZbumBmnhJxauLL1GGt\\\\\\\\\\\\\\\/3RvskGianPP74BKfOGBNkQxpi7\\\\\\\\\\\\\\\/ZBkQzbK3FN1diF6H1Gjks+WV1aH4tEfD6aYQmhr6vrO3LytUsiQ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/zBGS8Erhl8ABNx+yUN4u7m2Usk7X+PCcQl6\\\\\\\\\\\\\\\/tS4hro7ZUmz4pR7nZS2eyY8i+5GXK2ekiN1AoDSIkwrxuoFrcinVraHsSSAi6Tj1MwTbmcYUg4RTepgtu6MHN7OJn4zii\\\\\\\\\\\\\\\/7x+fZ\\\\\\\\\\\\\\\/snCh+Y0KV9KawTt2+tzwmEucC2Lo1ZTcQTUeaWqvCW9hWsIWCU7CGEswaOMqw9jb4DLWwgUMLp7Lby928c1eQAHrTu+crgZxfmCEsrSVa2cnFa6Dk6eIbqYfMAqwhnn\\\\\\\\\\\\\\\/iwJrsAL0WUn8ulrM8z3Z9\\\\\\\\\\\\\\\/UOWkQvRboH28xvajQjrWUwoOiI9gED4\\\\\\\\\\\\\\\/AR9vZvL9SjDFCmsSO821tz5KQB18\\\\\\\\\\\\\\\/A2hbkIgIsa8UpknsWWwZBVyBFmRSRVdxnuhEBkqY9BeGDLTzmOujQhSfpMv1Eo2uuCcLagfHG+8ayFzG7B5O1e0GumxUDPhMe4g+0HdeI2fHwrhyIIv9pY9gxatOy2jCzg8inhfC7Ac9lG70+UW53oP2laI0Dhkup0QJ1i6ys22LRjoA4AQ9dJJFpw10iPjH3vIU28+h49lfzkwcA\\\\\\\\\\\\\\\/5mhtIVPlw0QAg37D+JPETt8sWVuKxrv2cqsYOz2ymOqvzxZLStmUcJ0bSwjzHnB4Ur1D5CRuS2hOBKJnPHgmGiu50aTcbtyChDZygAb2F3c15h1yR+cPDK0EHNn9o8qYBnFsR6RvUQ+eEm+Lww1g1daR10DL3q6R8jaSWxd6szoHK6TFcG0YbNQA3UQinqeQZnvneVLcBcf6yF39gLbiVViWBLvJBkGoAjH3JZ7OQTbO6gJxYEQWcRI3KRD\\\\\\\\\\\\\\\/SEXNULXAc96gbFvnZWWSYJb0+56c5IGwNYSqQtRU2+fUVeqOpOR+GdjHyn4IHIuu9uFKtHkT0161D0c4EYTDSSjgrAxDLEXzXrErcxoRbiQlVwpt\\\\\\\\\\\\\\\/MlOoes27h6utRWWZwYUR4d2IDQPIthnpuyETnmkMY9yx7O6azwahPzV9irLKt4iHwYFnpERXdGvaA15MbCzAnatRWtFH4W2OrbwXRzd7Ar6b10IeRxDQfXPEZL6f7EDdUz\\\\\\\\\\\\\\\/iq2krJD2NLrdPatrfTviSg9YsqjXlORcu3rzbhy5TuRrCqy2J257OF2P\\\\\\\\\\\\\\\/rznmq122q5u40qpayqgS8exSXnWF\\\\\\\\\\\\\\\/iotsw9U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022btLYrVS4D2Mn\\\\\\\\\\\\\\\/2PSIj+lOA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022e91de5959b7598bfd2e39ae152fe8a0f017c19fe652e75f044d55c9bedb03a45\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e004856.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e004856.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004856\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004856\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004856\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}