{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00228NDC+jBNjN8fNeWF9ngRqFANxrZ\\\\\\\\\\\\\\\/gzjmz55JUysY5sUQKCBJ6V5ancFUPQZVNu0E3SRFS4w3DRGI8QAMcXQR0ZgV6DkEW1EfaqT2dyp6W8Gy+Shk6nb6fDJedxnMAouiKLKkpuxKLJsBwCaBswmIvhBtpqBEJYXrH6Uh0aDtYBtH\\\\\\\\\\\\\\\/GPksGDr+koCDVfDuSD5qjeTiYGyOcBVV8gjVLbEIE2kzCQRXywDG1PakyWt2Bq5JJKGuCEQokP4dzfjHJmtpjITpRomJSFTs1RlkmNTYhYBWdUUKW866BOypVz9SXgXiHN46rGGTjzlk0CWSiNFxIIP9\\\\\\\\\\\\\\\/o2e1\\\\\\\\\\\\\\\/qEnxbewdfL0mUsIF48KkErqv6mtDVvcu7MDqBom2yWvAUdmUBdk6e+lOAcmTX5uGwr2RuRmhT7A4YorUW9eJXCLMNisG304VNT40tNcJFWtyTdWedDK1sjvBmiWpYKoUMO7S335GnaNkYllavWPqi0Q7cNC9gjfIJ5eiuQxeJ\\\\\\\\\\\\\\\/EYpS2oj69zIRerEVrR0CiJ6tRY9FbLMJuqH6dGIqNIKrcunrn4Gz2jlkbBCUw\\\\\\\\\\\\\\\/j3K9yPgbB3c9\\\\\\\\\\\\\\\/5y+hkoYLfYYg8Gz1uFvr6+iL38ApuQKN7qAnV9YcvGkIN96Lb+HCjV2S03CrRDshsigwtOjZLUaJdaTGhomUzRKbn3LzYFRYKi52OgbK9FSg\\\\\\\\\\\\\\\/8tIfP6GKNgshtW4K3j0u+cp1U4actBcgFJ2gW1V4zBRatJU2IahhzVysGoMAoARwvfXWAxT1M28jp8OdgbzaKV1M3rltdEhjwsacGvQgkaCmudkWnZNZrxSIRRuFnXwLp1cMvimqY+OiX4ohbwb6bo9thfc0jb091Gpe8HLUjLm5HcRoL89SAO\\\\\\\\\\\\\\\/JnW\\\\\\\\\\\\\\\/V\\\\\\\\\\\\\\\/61YAIqQArchwwrr3lKyEgGuT1oJdxhYefERhTMPtx39Q+8BgieQdlkah7\\\\\\\\\\\\\\\/Gqhcj9DgWnTByaIY1Qu7bMyus8fs3Tuebc1UuWp9pOI4olCToUBaiCqwJl0nvdcpFonJJYilrKCPk2UJFetprub2jQYw+nrnEtXa4qiO8jhtjkZa+BUuCsgQ\\\\\\\\\\\\\\\/UoW9CKIzRTXdF2qcYOvoozzj0zDLiFArq+IMTg9rFzoexULuuPJzqqeoGeDTQSafZQXLUZEe0EtxYFimc3C2g9P+uPqyWTxZ8sokRP2Ed4jpzpMbnzNKr\\\\\\\\\\\\\\\/OLuerOUGHtHdwuJIhP+O4h+7wcWBdqFNAagFByrLXK5Q\\\\\\\\\\\\\\\/sfCoYpF4UJ4tMSYZDnRKyhK3BS0iuPi55P7Dm+y1l8LUxFqgrFyaHxbuggSPoGCc\\\\\\\\\\\\\\\/RjdFtjfQWQUqbpYvOzmw\\\\\\\\\\\\\\\/7O0hVFxIpSYEGLddxYExWwxF3tIsk\\\\\\\\\\\\\\\/Fp\\\\\\\\\\\\\\\/eRa1gkyktNAQOONEXITlLUXC+8tLXHMISZNZNv+H02nvfmLN27chWpZ+Ls9fDtJDRUWco5\\\\\\\\\\\\\\\/M11fMZnLMMZMAWTzg3bf1fxaEXWdx\\\\\\\\\\\\\\\/IuaYZtKP4kaJy6fE8SK8VfZ3KQnYF1n2u+AMq0H20WJsiK\\\\\\\\\\\\\\\/oiS1o4+QeyWQwEeA5HYvQaaybpqyOsCOM4QULKUVuG7jKPqLwZo\\\\\\\\\\\\\\\/mC2\\\\\\\\\\\\\\\/u0UUvJByGpmZvhQHQmvnKDis4Zc4i3KUVZAgtDsnPYjkH7dVXk04epV1pLKhObjbFGHYJ1l2zfqxUhDkysfOJ9QGApZERvuVxovS5MDugtgrw3kCb2bYEXd9dIMfkw6GzsjnP2ElAoZIssf+Y6ShKPpVLPFNrmlb6eJOLFSu+PfokrDOivOG+pL2ZfMWGEoyM39BY9ByTjyZ1UxEm3DFWbdcgWhdV1AuiiZejLGjekps6\\\\\\\\\\\\\\\/GSoobjVDPwlZk6sNmorg8rQaYc2vrqKLXp7CPbOSMM1mR0NN8mv8Rd6\\\\\\\\\\\\\\\/kV7iCrAvoKOtQMbdk8gORb\\\\\\\\\\\\\\\/7u3pMziARE\\\\\\\\\\\\\\\/spZbO+LRzyso0nNUdKnB7W33wUnAgW9WTB2amCZF6rLGRORlDeCFSAwcXNUMcsrTfOk1K6nIgjLwesYE100knUeyZ9htgxLGlajLo+wZuWsaH6cKKFHNQ0RI38NdYYgqSgWcytMypDm5MpHoD0i8WEsBiNal4ixgtN+OjrI4Gef11RDPuM\\\\\\\\\\\\\\\/wjxhHGNVQH2TiZ7vCmfE5gXGykuOAMjyJvHdytAdRgOGP8i7sKSDqEh6qpA7uRbbuULCXlKKnV2Y7Nr2arutbwF6RGTAN8w5VOT17K3N0w8o9v9gmEfCmDEgUODayRWEJW1pixz+LCVlUWoOG2NZF1J3Wem1Q91W9h8D7nwpdZ0i8yH3i\\\\\\\\\\\\\\\/LMjaDZbWra8FLWsRKWJZ1oK0HwHx+KTfyPx3Mw\\\\\\\\\\\\\\\/YEuYyfy6TXd+rh1kvorJ13ss7OKvdwxdGrKFw91axcWrN2fAazh2pDKQ45V9jf26UGx\\\\\\\\\\\\\\\/XSnmHTSlQ3IMJ8xrhebYp2x\\\\\\\\\\\\\\\/M9M0FxMpUx8u4GAvZEnMP9523CIr4te0UawoL9727j4BlkzkrYnTR2knEHj4\\\\\\\\\\\\\\\/1PDFh7DR6ipz21w7KO4CWxUScle+uJYSLHdI+I+xIFuE+CIG3nEr4Kg0CHrXuyqgfeZEaul03xorJzYXRWipZsTz4MLRGiHSLml+zOkeAo4kUmHHB5l2yVfC68rlw1il4Hz2rNLFOS4l20JMX4sQ62RfP7fCErhxABtxrlabeuQG6CKXOrJ+A9+bgaA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022MWZV497\\\\\\\\\\\\\\\/lnd9PQqIcIf18w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002238777593fa34d6eda38605a92d90bb4d80d41d88bcedf743f55b7021a893b559\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e004902.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e004902.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004902\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004902\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004902\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}