{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022BmQHl5d+EIICTFBfliSkI8b4ApxRykh2n0Y2uy1nOXU2OU3aQiInH53ewIWrH\\\\\\\\\\\\\\\/TN7QxSJDP1JNPeSz82tBS0F0d5DlY3ld4oefRQhfMOXV0OA7VAdAnCK0Han1QSnQyPxIDaxECHq5pWds9tG58SYeA3M\\\\\\\\\\\\\\\/uukPQO9T+2L07b+lfC9l6nCufCgQVUhNrQHznoHnv20tT5h4UsBFUBqu\\\\\\\\\\\\\\\/OyvV6Fpv8SfBrf4t9kxtY20XMmkW0cI3LytAwmJMyhG0AMFBqOjMHtsGOFJBkz99OnE+yUSMf4xJsKmXG8nk18SJDtakeYpz1piqD9wWLUsm9c5ahpyZ864V7p9etVjRDeSMNNm3uKKyX+W4Rk+HsARMRGy+6ZsmdfVMQOcIiBbPSVThwBoZWFXT01AqspWdiUCEdCYy8fsijU71Y1huZjBFeXMwQ6aM5B0kgg6FJxc3llsxwW1wYtpuaexeHEYY97\\\\\\\\\\\\\\\/KW\\\\\\\\\\\\\\\/1eHUX9\\\\\\\\\\\\\\\/Dkxi5lA7benjViza6\\\\\\\\\\\\\\\/vVvsaIfgME2WPkSUBEsZhBQy5eGzytweWls2v2BupDt0CFsguVr4U3g46GwDfMyWgNoTxD97NlV4Y9VIDAMOaDFYHbEaWidB4ZjBsFFfFeey5+JXjZ3ZmKVoToo8xDxJ4TDH\\\\\\\\\\\\\\\/nyoZTWyXUKGOlHtCtW4lrr1\\\\\\\\\\\\\\\/lplHcEuJW21zHK9cPI513UQiQAXpjP53XdfG7OBFnfJWav0soG+wr0JDf02WDkiCVzdbLbA31EW1y8s3MFp2JA8WkyoC2U4cRc44jFWhNZHmOJhkTRJSOOB04Pz0Sx+aWJ68LBJ9lLijBvvzgczawP+aiCw2OiOR+jrzojkPQVlfL0SpTKKBcVoSXRYFbZt1JpveKotNW1ScxEUfbDPC3HjHzpgWqbNUlDGuIcy9PjQ8hfI77oqlIVWNLmyqk68WN4ajqoltB0r6ZCFb+gsTaxaWjwCLpqKSXcwlsBhGDRP++8L0fxzjXuuqElj2niCtF5v5RYXSYDPSn4mVL\\\\\\\\\\\\\\\/BTveoEJXEj2sD07Koi6a1gdLT4iJATfBtwDemxa0nxanxS4e6cMWQZvXMBM7vnd3VEzX\\\\\\\\\\\\\\\/KFJxPDVR\\\\\\\\\\\\\\\/6mXVKZAr3fJKILGXgh52qfH9dh+egE6vEOaMxx4bHmIhZ3t2YijBnesXUG+2+MToHRHctcj5jJKX3q3RlEWqg40DfYzyv+zm8Re6tGh5XU3wilhD6eeobywYnsY3SzMGZmbN5akC4dtFDCVp0l8OoMN2f4dCp42VYTrqmD+t1r587z+QmDMLuXNvrVvFWgSxeXibXE5kWDszogif4Qj+x3BKVLhQoIO4Cn9Rud9vbebkgDgk8JfyuKecsgYzJNGZaS+OogoHYMjKRgD\\\\\\\\\\\\\\\/oanBdOjJv5fK2jSjdGplbzE7DddMg+uFcPoib6hrscviBXLyyoN9SoMUTrEsbGKc2s3TWyvk0vgzqdqt5vCVQeTLkbv7shXaUsvQGOfg4rMZkBpOJnK4XtgaQOT9CK8f9d9gJQSpOXZP3yDw9CUmMiY\\\\\\\\\\\\\\\/5r3l9BFLAvkYvwvH3qM5jTqqzvhZ\\\\\\\\\\\\\\\/EgI6Rh52PNHg9EiuvAfzy5DieyAcxaSezHZH6Nk3GNCI1pEr4CfVft6oLbK5qd2vLatHeWwvIWJlfM1gUYWOM20JZzP5eYp8pOmRiQW2LheXqwShCzCf1DLhfYlIJzf2lkDfedDZX\\\\\\\\\\\\\\\/MO+GOQ\\\\\\\\\\\\\\\/Aq2U2+q85DSQAbWgjegxDXOO2Lafk9uu4DpHBkUTeLdkpPTR9CZsU3JOpWKgyOEEBN03YUKuDA+6we486hjC3EtkP5R0\\\\\\\\\\\\\\\/gkKZ5QbYZMrucMcBV94LDomPmFj3WhFdo+6WyM44qLyTVTMAmfxYShoJU506aoE+rTbKu2j+s5xzmMBrGTAXpQzevmu5+OxuACnZyu+S\\\\\\\\\\\\\\\/hojzCb9x6vBq67NR71WOpk1yXknNHIECzto\\\\\\\\\\\\\\\/ChrNZIp0N8hOGei\\\\\\\\\\\\\\\/HeZ8KTzvDdq\\\\\\\\\\\\\\\/Eoi1PTVwqjayqGn8konPfHJIjBf9viM8Jd+J4ntMs0DeoPgxt+pkVVXAwwy4VbqiGjTVa6CZ1+g9VfGTaMWo9tKQ0tVCUj3vGdUvT+rm3JmTnA3EhWfuyXiTZWWxli2I7WikaAW03FdheN95zCqhxdNoJBztN9Ecy16bxrI0pYLjwAq\\\\\\\\\\\\\\\/khn5Eiv03sxzsCJu8LAWCKbIXjBJBxGI5c6b1cB48p\\\\\\\\\\\\\\\/UsADgxQEpZ+JT9OKQHult2mBuvMGrSeyX+qkHw2kcnKPW66Y4Rz7ai9MeKYQbZU71jP2qk+AHoOmMZxzTv2dotvlJhGZtIa9KoSXbw8HowfFcJN6Y1vewybT7YYGwbDImX2VsxdgPyCZdlf4Nrx1ARtFZBIDDV14jyP2JC8rktd5SAkkyQf36hCnf5bXk1SLo\\\\\\\\\\\\\\\/od7fb7AAY7KtRCGVMI00P5CSeK1xReyVfMjwd9sJVD+lCQ3L2JvPcjCPm61t0awVyZStU1co4ET46POOM9Bh4\\\\\\\\\\\\\\\/kG7eEl\\\\\\\\\\\\\\\/EAosHxZiXSfpioXbhbi4mZVdPtuzW7caoB+gLHrxwzCFKJEClzaRstQRpJvro1eN499mwkahYYaftCWsDAKO61mU5FlQ+qnCyjZh52Uujqt2TZIM6HW9idv1kZTmepbKp2L2IRFRRbw+s4ZS7Nrkus7bmwTPD9SImC6Wus=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JE7CNdXohOA0MxVSFr6UfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002299a7f51b20218e8e067c5f3df7ed749da78773ca51cf32092597f50890984e75\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e005141.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e005141.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005141\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005141\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005141\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}