{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00222vaptPjOztBu0NUcKdQ1F0dxlL8CnvAq7GLJK6dt39UGzOXWRoKGyxwAzuXmoI6aLLT+P\\\\\\\\\\\\\\\/zWA1dlRjc1\\\\\\\\\\\\\\\/vMCZu7gAZTxdVt5KymbZpihsfqwvxh1HHT4B41sfAFFPo7oO2vqontd2P6UgeMj8lfmiC1jbR6ZlUSYk9Iqc5cxxf5zRocMDh\\\\\\\\\\\\\\\/+JtMJ5IsC52EECcVSk1JW0kHTcjGfI90Cc+e2rdpR8K\\\\\\\\\\\\\\\/FviYVkhrMOdTkdanN1qNXyRzPExra3CicoinV4bxHho7Kn17SpLtQodM7Yz3JDvdkcLO3bwPsHxstMpNOCPA7ruN7sF2fFHy2oHaa1Bd324J8eGf4RlwIdpGjJ39\\\\\\\\\\\\\\\/yOafhkjmuRsTumVuGr0iQX1id0pMtJk2tajxipz88RkAfRZQzP42gSfbDQqgzwCEDj3mVWd6vBPXu8Svh9YZQ7ox3sibwXzpOjc9GmLZynwd+w5HRMt09z5SZdry6zUrIlC+02q0wahNyfko3p9F45ruILIGDfwlRF0pU9AG9C6e+XBRTiLup9BOQOO\\\\\\\\\\\\\\\/y05Z+XPYWaRioZ8JTz8EdVKUemj9Ww2QeE5wm6boBoSUuVSwnTWFMKO7kxYP7vR5M4qcTOegUy9e4CyNMcoIgHfESB9XaWjgdHPSnwE3fkncI5zMUoizrfIcYs4gYKbXz11XAtA834Wuo\\\\\\\\\\\\\\\/veDggseAxXZIMU1YZT\\\\\\\\\\\\\\\/uxmypy33KJHl4pZMlSDPvryd70m0\\\\\\\\\\\\\\\/RCt61N\\\\\\\\\\\\\\\/FDiWKkNwrjv7kpOz6SbdGHjqc6sNumKNVW2Hv8SAkSOUhEpdYZHyAtMKRSEA\\\\\\\\\\\\\\\/Nnk1rT1va0r63fmYg3CYJ\\\\\\\\\\\\\\\/dygFphMC3sfUD1tFhO\\\\\\\\\\\\\\\/5CNOE4lt8Jrg0QuWzJMoFZc8woEvCt+IhJtm720Lx9TH2eV8j734DsXFi+cEM\\\\\\\\\\\\\\\/G1RmJ9RvUbILfn65bjMnrN557A+7l0Jhr0obDsm1Ne+vmOWDvvtNRZUt\\\\\\\\\\\\\\\/c\\\\\\\\\\\\\\\/rGdnhl4lvOLhxmhCOwpKVpkUFemMNkMthVoO4JDjCOE4+GMDxj4oeGJuCHjVA1adgFeYy0c1dZogAT1Iq57cKNx7BVfF40M5rXnPF1O1q4pyKF7Oer+ki0A9erW29gPAsAA0Z1NlQevQZvAwW9khLxJpVeuKy3BIysKKA409qkZq0kpiIL6fnKmceBq2N\\\\\\\\\\\\\\\/5B06kKBnz0LLYTUytby26slwSq55J41RKasXfZZX7qRx6Qme3EFYFeGKQTq0vk\\\\\\\\\\\\\\\/hzCUlFzYaL1MYrydevYD\\\\\\\\\\\\\\\/yKf74d8kicVqvZFqXkMSzhGZuysrOA0d+tcMoZNDAk6J98kvXOKDTI8jQIC+o0hPaq5RELNhGpbyjxu3MOuj9qdxLC2Ew9\\\\\\\\\\\\\\\/LWB4ZdNBEiNNoZAVnIinE0ZkND91H\\\\\\\\\\\\\\\/vhVo9D5VHg94YzscDWBGNd9q5aGUjbJGlxfKpFcaxoa5al5urBIoGTzvWSGTbpnxahLC\\\\\\\\\\\\\\\/3vjtQ+KTnDK0zFXwT2y7wcTx6dLfTv8Z0wju+UBthLWkWD7mwAvcJXy4O+xHbWh9tEpqDxHwmlOEcexFfsVnGsDGxTVGE26S4g08BCi7v81vL0SKwTQNmEIClIadoXCWk+WCEz+i3ctQavfdFTcdvRFdJr6I4+UJd5iX8Acig5rwZ0DDB9vFMKR7TA0U0cjeu3t8gTGWJowILkUMPg0zwiHQOIs1Aw0nojbjdPqAOb7Mh9Nw3upXidgBLV5BE6xSHt1sabx+tDiV6Zsxvpb\\\\\\\\\\\\\\\/kiD0MEMLyierYtFssqalJop7NinH6t2YpGWoAYAXOLjBP\\\\\\\\\\\\\\\/FVl6IYpHhxs9FnXmrGt2sg0qbmJrjNeZ9nxeeCqQIH\\\\\\\\\\\\\\\/Xp1L1EYGwz2F7n76bW5+Iu3Fbe9sikteVTTu5lvyf8QcafqsGlyRKMzFBg5zimqjGrPpg4dYk85oP9beU63TE\\\\\\\\\\\\\\\/DHIiGnaCU3d75Q6M3xcEdq5Ps7Ecywu\\\\\\\\\\\\\\\/jSnHCaCFmCEKnQqTw145R+G59\\\\\\\\\\\\\\\/81MnZmatsO48G01DF+dDxwcVl4lLdAto34+CE2RSvS\\\\\\\\\\\\\\\/Cx3584LQypm25yHEYHWfhQPsOR+oJHJEsdR4bHXpEKxdrjezGeHGmtXEcDeOI4R+4dr7EgSqAlNbtdnZEHerDlP6UiftcY0Dplzxk26MbU7B+k8Ie0qeAuBatdfNDMqRKzdz90LWjpd274rFaiyTAd+9x88ANR6rx7DJ0yv25llQ6ywar2BJCGE5LcDqGfD5WAMehQ1YxZe9rDiVwV1OJdgkJy3PR9jIwYcHBABHcXvMXUs6ED4ITcR3kQhLhV\\\\\\\\\\\\\\\/WNlnFlW3Ak4zWm6zAKH08vdpf5CLGRKeBIN+cHcHR+knAHZGrbqmI\\\\\\\\\\\\\\\/nf\\\\\\\\\\\\\\\/+qDLXCdLqQewz1Od5mNZrjiJCF7ArwuiJv2IM9H\\\\\\\\\\\\\\\/c8yjJOlw543Pz80fwGfzTxrMW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9SAfMpltyKtLK5CAOoWfdX1E6oLNzCiWLFbhnwFxaTljN5mT\\\\\\\\\\\\\\\/+Q+dGTCd8glcAOyhwOWc4s7LNBIInV5OHJ8CmCFmJHkYaJ9Ghqk9XuWYHsf5F6ICY3F4RS3HjofHn+cKhWDR1C1y24F2kLYLKC17iQc7LEPg4HVX+rqO8LFz+g6FO4inLV30Rp\\\\\\\\\\\\\\\/RpeSe514E19FFC7zuC6iVZVNuABfqeQZPjbp5RKP9gDCI2ud2Sti674RUfw2Y9E8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/O8LQjTOaDYu+NfOjUvWiw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002221e726a536b4524c574b8b3204fe8c2ac36742b4d92cdae17287fe6cc851ae41\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e001731corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e001731corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/9\\\/e001731corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001731corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001731corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001731corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}