{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022bVMOhqnwer8OQfzVYu\\\\\\\\\\\\\\\/7ojiKPmlzIbNQi+NT2q6viuy9yx\\\\\\\\\\\\\\\/ROQj8O7eU4kIKbLJSJjYw+oUJcZhVfzSj3jcieF6rHoacgDlUjkxTcss7bZp3FELldN3nFi5g6iy9scChTQ+RwVLCKz2xOaFH17NIzYvKzMpKp0Syy8dsDTDPFuiqbfr\\\\\\\\\\\\\\\/5VZzzkUJoVPiVrxMdKkDd1f4rniNfdvzQgPsRBCur86mKY\\\\\\\\\\\\\\\/aR9XK7slCm\\\\\\\\\\\\\\\/sCXNCWsr+V3pswAcqa2r8nnsTVlFMsFpBvrCd7ncY0QPjTq9A6AwGK6QE\\\\\\\\\\\\\\\/pPsRPNOUhevnR9B12bjyxorEGLdjE3\\\\\\\\\\\\\\\/tmXAfQPTKcKLvDun0LeyP7jlmR1kzLY4NovPsVHZosqQuJSf4nhoSfOriigDmj2bmwtx7kfEaszinzFmy5dMQ\\\\\\\\\\\\\\\/3akk\\\\\\\\\\\\\\\/6o4P8IF+44Egla89ezt75D+Qds8k8vV+1uuDmi8NNrNxam77Hs2DEE8dfFMrgwwyo6n8F8qCEqgH07DTjcL1m7mkJnpPqPzIeKnFzq38HeFRl2RJXz8zOEKHY43TltoeOf+Oe5dohDn0tBt6M3tIROGZU7tIsj0TSiY3mRucr22iC6hmCBTt7LcgPm6yPu6Cfq2V2p6Ds2rHPGvHsU\\\\\\\\\\\\\\\/RbvMlgAl442lDlH8hBVilkfU37XLp2x5vkTFoU7rsV58uq2dKc6Sl5lG+Fr6vdHiqSrYer8b4a2fnCTts8pM7BW\\\\\\\\\\\\\\\/BQeRyJv6b6+zw+iEvgtZ2eJiaEIKs0\\\\\\\\\\\\\\\/UlbRo6xAhc7YUVpEMkXZ5L5QFKjOk0BJmJ9rirlyr4q3fiPN0mVDzXsV8vK1A7okQjPKdyqQH8zBZj23zvYV8FuCy08LRQXqspsLRcxQ3BH9NPEEGLW3hbZ6ZuVqhSpwM\\\\\\\\\\\\\\\/6GNz\\\\\\\\\\\\\\\/aDYQIzxxk2mcfyI8AvTDNrpV23vLUibm1Khid7aLtcedzhjiRtHNI7oXuhMmiloXJht9oZv3HLzqRVC22xFL0lvPIBJWErcMkZXMBc\\\\\\\\\\\\\\\/o7XyvtDOWCxTSDivhdrvQMArm+xRrCtZUxsKMugjtFgWyTe8lutWU0NS4iyRklqN7efeM+XXxQkO1MBDQ2cCofgB\\\\\\\\\\\\\\\/tC\\\\\\\\\\\\\\\/UE9a1Sw+uqgB0BJ2d440jvdu73hv60mPj5vVrDHUokgGr5ZDixVxrn6PHCO44gMBrNuXUUgZk3nt661UAa0cZ03IgxiX\\\\\\\\\\\\\\\/SZoUtYvsoduDkqL5g1VpiGpDP9pOgnD2TVfb9W8NXVhGCmqZ1WdwD6cNWXyh9Els4lpKC4H6QdtMMlhHjumtC8XZCNCcz\\\\\\\\\\\\\\\/EgfgcSGYQCtpT7uqRr21WIpCgsvnCAglkpzZdnWyiUjCYSiNQxZyLyIwq1ZGOER404BtP43YIeyCAeYXTkRLpQn1Bd21rS1y0OePcKBbE0KyVyVFfG5VvmhetBGRPJeGYmj0a94l4Ecf\\\\\\\\\\\\\\\/SigiznpV2obz9o7Y929UKnYfCdEnkP+Or6+H8tOnj99RoR7at\\\\\\\\\\\\\\\/cnOVG4Og+b634f9YbbZY6rg1sHKSAHYKsdrFnLESBnHYP0yFUZpG58tVGW6rFMGaYholxpOUrvPnNxuTt0MJXMN3KIsuY9A169QHYpcH4ZgVebwYEaXWrR0BTA+\\\\\\\\\\\\\\\/gjLNDfmU2dYSZgpkD1\\\\\\\\\\\\\\\/Pio\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/v3i7idf+2KplZCZiFKndGD7njuJfUxWx7I35dXMI4Jax0B1u0GQF3eBWfL6+AjhwvdOtWakAbraC+cpT\\\\\\\\\\\\\\\/Lyzy5OUZAo0QyGLr7T8+7bS0I5tDdQV88QRHH24gbjb9o3NQVzdls94AZYfl06JNskmvnqn\\\\\\\\\\\\\\\/hmevDPyiLT3Jsx8jUQa1b39leR58EnkQFpK5Mv8e66FgsFS3EVyLnoPR4Ue+TxVN8IMqvPRB9dSYXKg5cuo0XDTeXQvXdbGC82oBSnRtmUj2ak4GVTdBNOWglSHrKhPFSImlHdoUpAdblPvjlsItt+1jOa+ogyeexfZDXLTgpEe3KG0C+SYGzQxW2zyrEsS7xi5cHwHUyKHCPQGrHuAPv9YQstVLa1urRXcrAnSmuICGVwr+Tm\\\\\\\\\\\\\\\/ZJCHnx85ZEZjeGwBxb\\\\\\\\\\\\\\\/a9jlCQn5LVawGuGf5qvIrw6RYHMWglDfL9nWVOGsOD9y+I7pgiGyXqfeM0MtUKvcHh3hU1gjoYkEziqzz+TYXzAWR37SU0zIFPl7hgaysZCGbOR+OCUmjk54z\\\\\\\\\\\\\\\/ERMnMrn7kdFbQ05QXcJnCODIaedDOkksztK7n2TmcZDECww7CL1HnEO1X1iKAPCBN2o8GXWAOmwJX3HlaiWSYFsrFHdWhuD0dtuTUooVrYcCDklN1ji3Te9CH0tJKJ8YIXn8Xa3m8KSjig7KuzwTtn5dBJ2V5jvsCLkLS30EzoQ9XNZW7bmh1KJvzqovgc9bj9Rh5AJTWevQPhGX1Mty6HunwXh1vDKwhLkqnLmuYQ0keeExsYJv9612MLaeTyTexOFbePDaUp9i\\\\\\\\\\\\\\\/VbGsv8dwiv8\\\\\\\\\\\\\\\/FHz9xPNx4ZuWClT5vA6pHXfFnQUbfN0M\\\\\\\\\\\\\\\/8JoAKxwxGExe6YqcXb62nWB35CgQlPzWbh6siqAaemV+OYXTOP5fL7QsL5vS92weS3SnSNstYInzTCj7Vr1Rd3o7JSyRHnbg3o7WqN+1rN898w4to4rW6i8SHJN57OJtw53P8QJQQU8QYqkmSbjtxwXE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DIuq3QJZsdGSJsZdbJSIfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c2439e379f992751dd5a2ff0cf39e09ac38a76af331a43276c94efec248d80ee\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e005199.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e005199.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005199\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005199\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005199\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}