{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022k2i20kMGnO6A1lH\\\\\\\\\\\\\\\/1djita9RuKHRTxDMVaniN+\\\\\\\\\\\\\\\/551\\\\\\\\\\\\\\\/H9ffQCsSlBXQIfipv0aQUFVxJmm29ZFKoF\\\\\\\\\\\\\\\/dw8cpYBMD+NL+DAr0lMjFTT1oPOohOHgK0MK8H4Pm04dHJh5wlhsDOTgKII1MCEJDKkLkLpkhjUwdzlB\\\\\\\\\\\\\\\/Pg7ojvaK945z3nx+GWCXR6mFt9xuGuEmLp5liThxwnEdNL3pHRo59BlJDJqJA1HYBkU5XeAqq4W\\\\\\\\\\\\\\\/z7mOfqHWMFnn2fdD0Jx7O\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/PuwSYz8r2OFE6SV8tBE+\\\\\\\\\\\\\\\/j8ge5j9PxUslnBWtOIk3IQ19w14p4xP5hKn7B4IqMrohxeomHvZIzRsw6OhJyVLzJMsopjk77eM3yjXsWbrU+YZ2hhZWPu9qoww+M\\\\\\\\\\\\\\\/43rSumcwHU+bUAXQLp7RqG\\\\\\\\\\\\\\\/ll8rqjrs4h4crJbjWCx2t2Cc+qj1088FKmY+3ivxgv4BDBh0hwict40+O6SrgFIyWkebAd7fWGeX3hgkSP2eLmCRObaL2uYDxXC5xH2W7wh03IVOO\\\\\\\\\\\\\\\/RoUvn2upcjPCDZ1kA43M4jcidge+8qSc0M\\\\\\\\\\\\\\\/ZWMK7YLRQ7VbEbUe0UsrOwB49UufRe7EPFYiLOLO+GIe3Duq\\\\\\\\\\\\\\\/T73T4t\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/S4Z\\\\\\\\\\\\\\\/YzHk2yLCx7AHfbjG\\\\\\\\\\\\\\\/62rPtER6PA81M3UswuoRDVs30Z3yr1nV7arT+r\\\\\\\\\\\\\\\/WUiYUXuDR3C6t1hXw+PrdS1H6Oudq\\\\\\\\\\\\\\\/mwkZ2SRYATisiLtJQGIKriuNWv0mGf5+yrSO+8XthpxBgqC59MLAIug65CQbgLcqdefdEk5AGEANIgNNv0B+LX04B17fTWVUne4C6pv3SV5pFyyDbA3VaYuj157RfNWxxVZAZEKHaTYUOdvmEjGqukzExxKWVtnJO2RaCPVG8ZT9H5ArYyYpKQE1dsM8+uwc7BxWi+J85MP6xnR7SbnpF2XpZmxP83o5\\\\\\\\\\\\\\\/NVAuySmOCDmnzz0fSfD3Ma4KXqgaV7DHX7oQNkCxpyG4ZdQq4aNwSUAO6BSys7Djzk3NFx\\\\\\\\\\\\\\\/sF8aNceWeQKXFqVNVsGtY6SqOK2cJDLI\\\\\\\\\\\\\\\/J5\\\\\\\\\\\\\\\/kWhUQYWMzmdiQBl\\\\\\\\\\\\\\\/xfyd8GbLFilPj+ShGXNVX3ZlKIyXOs1lYrPSJ0dEUn3+JG2bvMX40+SludG\\\\\\\\\\\\\\\/MkLOvwI5DUZso0\\\\\\\\\\\\\\\/+l8G9ZLjoOU9Q42bqCrg6nNTlhWsN8DLxMbL\\\\\\\\\\\\\\\/Uu+KG9ZRpk5sF2UNGnjkao2\\\\\\\\\\\\\\\/hXVra\\\\\\\\\\\\\\\/8evU6SpTSw6TUJBls5LkinSlCye6JQjMotKF38rBN+kQBpe\\\\\\\\\\\\\\\/P6IYDkKWf8Obj52E6TEVRh2x7JxQmQTftx7BLsU6ayz0HAr5Frh7VjczQUxeuVHnvNuRStNCTcjkcT\\\\\\\\\\\\\\\/vXu75naoBNR\\\\\\\\\\\\\\\/UL8corKdEp+Nk1Ha0bOku3Xc8W\\\\\\\\\\\\\\\/AxK2t7SdESgKveFz4JlD29yt4wCLBGm+OVV3qGf+xJ0zD8EhMsvuosp6h1+CtAIK+\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Ce3h8dFgMQ\\\\\\\\\\\\\\\/M3yfpvfSgkUmSf+wYjXssTQAdbr+MsIWaXSH4w4m74l+e8FA1r8DLzXPkQMgcsR0qWDC1MuDx9UFd1ngf4GfmwH293z0r88SC1Z0JDip+CrZ\\\\\\\\\\\\\\\/hgScUnXFKXGrSnMuH2bxIsEGoY1qQfnygUakW+mIbJTkxduoP4LnWZ6+g0zWoRJvmvw1HjBbh\\\\\\\\\\\\\\\/dRl18NEl0BiF9Vh9a4mCA7fqkt+DjqwFwOdrFiezCeQkHIdHNnNTzYYAjQtpIfRIJT0\\\\\\\\\\\\\\\/eGSn8QGECXr8Ek5iUOUJPXQ\\\\\\\\\\\\\\\/gj\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/g6clO0SB1GFA\\\\\\\\\\\\\\\/nRKVanCvt22GA4mle0kS2NE+I4AGYqExMo17a3kaR+Jet\\\\\\\\\\\\\\\/UCYesuIRIzICNX9cReGH+PoK8r1DQHVHO+ueTVVAx4evjfPbmCAHn0b6A\\\\\\\\\\\\\\\/ASo3+Cr4BXhZTZSwgVBNMPs186HYPHSyuZrd6waQT1OfTEXWc4VtqmIoGwvwtNWvAjJXn9p7PbPbTrEW4r2eLcD2jdSJKQQMvYn59DvdIDrsoAqJDroOsmDSUi4or3RKt2yCby40sSdj8xKFNwkEmyKuc8ugXJAqGaGXUihjPmrPJBKAgVvgk10YaoMALVLCKwdC9GZ\\\\\\\\\\\\\\\/X1HSD\\\\\\\\\\\\\\\/iRw5vc4I9AoyFuvglaU7ZLOOF4taNcWeSqgC0hNEVsSp8NgAHMorBKuIgfLMTUaAFM38vkiuWWRpVRBEMEiyHvZvG7x4kfN6YLIuspCad+i\\\\\\\\\\\\\\\/JGegFl5GsJSwB0Zqsp2hEtkdgC\\\\\\\\\\\\\\\/u++bVSh5jcbCTebdDhzeExXW2cIo0EeyCsIKryuL9Fy9SpF8dtt0h50sQ6UtD1zSGOhlglVF4Wb2W8kESYP6v2OUUqG+M5ObT7+0DkZJvMrf\\\\\\\\\\\\\\\/RufRfCLjkIuWXNN4XPEV++uav66Zsb22mRQ\\\\\\\\\\\\\\\/BiPQtvZufoAC5ffi3yX6KNTYsNu\\\\\\\\\\\\\\\/wWICaZ0ThaDe3Cgkz2rNMwYHagK2EnK2j+yaFJnG8nGtRtLAMyuwmeRMqP9xYUpEfzHduDHHxwWZtCmR7Czx32H721VfLvxqQvv+JZOG96+8ENgxAo3rssTIuEJkcQD3Pznj1BUvvvkf2rQjT7+lHUMQSiVTJrF82TK8vsKNGIW9mbMyo\\\\\\\\\\\\\\\/EfJt8uivTRBeke6ejqlsbMPV+lo0TlR8CIDMBWib1baNnRQJptiAbQweO83AWDuJc\\\\\\\\\\\\\\\/mZ5PzsTZ4+mjd4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JXm5SWXepAQo2tH\\\\\\\\\\\\\\\/xjDXEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002263aded8305f3c32c4828da4900812f6cbcf5a66b23715570c996ac387fcb4d2d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e004322corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e004322corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/9\\\/e004322corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004322corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004322corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004322corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}