{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022fkTvVupm8ucHqy3JJcCIFR4zghdd6T7ReMCjW2cFPPZ1iuNyuob8aPlZWaALthq4X5cJr9hwHt4YN40VjW8XfPOo1BJhwWnJx0FtQ8C3LTaoqT83sEX7biVd\\\\\\\\\\\\\\\/FhfSrprm10cEx9QTWZeAWG3NCbsrNObu949xCnbzs8ccEaRafYGGxVpfK+1gEyBit47o13Us4d0hU6IAAx2hXLCqsA2AfELoY0OeL4LEEGNSNLuPPkOhgBZFSB0NkZ89G4ckxvC9uWgM8xrIjW1oSBncuwRTiiUE+G6AhrTEPymi\\\\\\\\\\\\\\\/CvEp4RDjx39RhfamaoUOvGIAfkIMAVAhRyRnLK79KCar17aVPPjpZ7z74EEB3rjoSE0KALgjtDlb\\\\\\\\\\\\\\\/FeqJwsr0pB\\\\\\\\\\\\\\\/cFaD\\\\\\\\\\\\\\\/8KjBvrDCwbp3gagn07rjoLGR9K7VulrhXlVkGS3rsScMjomjHHLNUhORqnTLOc6S6k7T+ORqA0e2rNN1xgB+FdAjQ4QMW6akbaoxFzaPcpgQi5LSZC0KFJ+I2vnzBStBXtNk3O0UgBDrQejf0qA+YMIBC2+eangZoPY0eYaC7LlKIvMJnAn0boiAdynhCv\\\\\\\\\\\\\\\/z1rOt28Gkt0HtutLZv6FjRPgWrH\\\\\\\\\\\\\\\/eLAF7NR9wwk29PksC84Tst0V\\\\\\\\\\\\\\\/Djg0Z357KtA7wj4TJE\\\\\\\\\\\\\\\/DGx2qVk0j4ggvkJ4kE49QyBGHkZJBYBeWa6pAKfmT0xZ1NpFIFft1+kyxp7Wi7gLDlwZY0W\\\\\\\\\\\\\\\/1uNNSnyzwx3QI3LTY3R5CQZHfFEQE0821ybQbA2OU1q+Gq3c8PHs8MYqkoJdFOuaDytJh0kHuFA0bDkMZLJLmWPtNBOrhM6RvvGJ6foWolPOxkc6zf\\\\\\\\\\\\\\\/W7Awjhls4gFDzuIFcmREbNjeiO4uvueQVaybS+skzRmGjqaFgXrSz\\\\\\\\\\\\\\\/mRo8D6vCmq6Aqmm9njn2M67bJQUDeInfYMIe7P5n74Mqhu3IUgGAXiEOPASJRJkJxGHTxfrxDCn++KGFjUvX3d5Sclh0exZwUFSyrqhxDhSfEgKYjw08e5RWAPC1RPDj2OyQ7HNtbgl+DhXvOIrtThGq9RWJ+uzT\\\\\\\\\\\\\\\/hS5YeejPnSRe21\\\\\\\\\\\\\\\/a5cb6Bmzb2EykyOmAB4MrAXrHNEPIBU1jsISat4G9nvJmZrbbIT7C5nKFa4WNNPyItA7ADCeQ+BIAltU+Van95wWwihV3XXg+Csjs1ZZ6GS0XKshZiu2LC2+HUsg4HERk7mtPNvw10ixNkawCEy2aRDvXXJft62jnG6qJwOr3CeDfqrSsC7qUHvwBok2Get5iCRCvuz\\\\\\\\\\\\\\\/ayL7tQkENsU+YetnvErw0yj4IvnaMwN\\\\\\\\\\\\\\\/+5yZcUV643YYn9onRHKgZUeHe\\\\\\\\\\\\\\\/3UQoDfS\\\\\\\\\\\\\\\/CAYquy3LHieVVZ4XWfGq8KIeAc0Ui9oPn8CORoxHYVCWeJC5S5avhfAXe1xPQpaitYChoEgeB0OaWod+LwttKWcFSazt7fu4rdgqNJhkvXcPJhjRarXU9\\\\\\\\\\\\\\\/eZ25J\\\\\\\\\\\\\\\/DdjPyrQxxSAu56PgITmb7BT1kfi6QK8XFyeksWdXVTZ7UE1192SGylC99nLTdaBwNvRdXs8COIqRwDK2zYxGv34WR8\\\\\\\\\\\\\\\/85\\\\\\\\\\\\\\\/QfENM5stRO2OefX1vDRD77B7CExJJkrQzbans25SNnnYo2et70uFfUOh9R+j9H0NErn+8Ud4isJxPBf\\\\\\\\\\\\\\\/D1a7M0x7zwytsyfk4qeToogWDBiwAKecEJmw1oobMG7QTCYAmA0J9pbRPeDRTCzGCekYAcWkn4QYmW5Er1VZjaplsoZZAgOlv7iZyNR1OEjdX17EYzQkAOwBSeCAkkdDIy90xnmdQTje\\\\\\\\\\\\\\\/ZHqo8\\\\\\\\\\\\\\\/2aB+KE4KGoy+ftO+DbZhtOq4aBudYjjYyd1EtqaVKREDDzFw6I5tmy8oeFYE4TUIUuqhwo3MNui3sefyvRH0ssi2MbLNNqgoV4O0N4sFvmJ3zrFP1q6L5v2nDh7Vg1qEfh3v+UbIxom5vMEOzFkQ5brrq\\\\\\\\\\\\\\\/kDzI9crjP\\\\\\\\\\\\\\\/1KGF3IIncD1RmjDyguekfLfBAzHJWIY64RHnueu04oedXjSpUW+Z64NX9ZeuDld\\\\\\\\\\\\\\\/DIyfhzoayTHLCeQGhB+iphtT7qYr0x8TLi1IivP84Tm34my4STHTVlCSAnCpLPULOPSH725MkW91mifW8GBk2\\\\\\\\\\\\\\\/QyvwB4ZI0XsiQLtQzhzFK5vvmN2ZOTS5CC+9eKrursF5FKpVvJh9fju2e7PDl3rCxJnKB46L54CouJ5vk0q4iIebpDsblnI7XR6RdfQPD4jdeQNTGfLKLpE\\\\\\\\\\\\\\\/2H2j7VtSp+9zvslJs1rejXWd0up2TWamQZf9BjTwgmr\\\\\\\\\\\\\\\/9tibze634B51GHl28gJHcFCH1VSgps3Y5tPPuybou4W5TGBNA3xroM13PTOI89P2+4qJGRX14hm+PaQ4qDVUTIyE7I61Go7Fzg\\\\\\\\\\\\\\\/RpolN2zzAL88+gU7cktlF2jzFMniubQfWtRJfcKQLd8+BT6YwKZ1DuEXQfxwkSmCbWGT\\\\\\\\\\\\\\\/DyBSBig1Sc9mfOHsIjjx+K5E1OIb+h2ffZvQ0w55jl55DVSMV7waL7RJdJvPpKKxJOdyQynvgwAU9HKdOgDWCAK+aTE2GJeBNopA2MMoRNBks37lb3tb1D7PyeJQz8qwVzTM7UTXb3XZmLJ9he9VRDkUcX3\\\\\\\\\\\\\\\/byJhHHeMadNZhxCb5RG+GxI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022g0N0IdmP+2QvEFWH+E9NXg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f1c79a9fb1fb127be7182e36b32751feba4ea989eb207214102b71dac3df5740\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/9\\\/e004913.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/9\\\/e004913.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004913\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004913\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004913\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}