{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022TumYtjB\\\\\\\\\\\\\\\/9W1TvuVcWT7XQPzKEFBOxQdF1GFFZmIfKJ\\\\\\\\\\\\\\\/8vzeaJzBETS7kn\\\\\\\\\\\\\\\/TclrPvToIrcecRWa5ZrTODLqhiD2muMPBR+02OI8x3UqboeUEzdo\\\\\\\\\\\\\\\/vM83LG\\\\\\\\\\\\\\\/pG8M9jpDE+BdkNNvOKgEzl1WmAMU9XbJw+ZYyTqQD10hKjdKufS6CoFatkV2QADiaO1FmKv7+sAe3+8LEGudGAmwhygAr8vYVG\\\\\\\\\\\\\\\/Fn8U\\\\\\\\\\\\\\\/jz7+UYrJsoRspq7R4LWBi01lzvXX1vAXp+YX8aUX8XemPK2DjFx71uAmY4+cO2lfc2gqM+gV6ngf1FajWGHCjbyY\\\\\\\\\\\\\\\/uF7RoUNDfVtFvj8vhjgNvzM+39wjZLUxSfeKZLRVzOv3oCvIIsluQIvE5s8mCuusaXrcAwUqDUTnvDaZSlfT2Egiik2ILKZV13+BIsb3hOeGQ8kVrcsgpNvY0mh0P6aro9DgAdM36rHHX78utjqelMCyqPr5DV1eM7qVs2VUq1cJNeYf4bg9OUIuGWDNY5BnjqAh+45mxORlqiCkYqk5KT5VQeOatveKqut9RNIn4SY\\\\\\\\\\\\\\\/FbcBlNby16XSrHmTuwxejeZl4okBjEwqVoobBgPbum7ktpz9IptjInnXMXH9wcp4CmLf06Xl\\\\\\\\\\\\\\\/jMdsMSgKvPFyckhnDUz2Ntqtp\\\\\\\\\\\\\\\/3LTvjYT\\\\\\\\\\\\\\\/SLOO\\\\\\\\\\\\\\\/GLp2WNL8sopOfGVwme+eAS6ScZ4Y3jz5OV3aa0FEDHlPv1eC6qR5qOtl+WAOFElXUTISnUELrzAcpRTddvYm6Rvh3L1LjrdV4JheJbuB2\\\\\\\\\\\\\\\/+CxQNYjojtrZREAczYrkgy6nOj69GIswQyBQDbqY4fTRv\\\\\\\\\\\\\\\/SSO0fsm0MPz6q6AaShfv+pxxOwcWFOsfoydAyMUh1VbI3YfIdHiEPvMabd+ojgj22aZrIu1O2hDVJm+7lJYLTJgPWaJpTYzXwHoEU6f40Dj\\\\\\\\\\\\\\\/q82JJzHwyUgpgqnQ1okqK2KWwciIMNU5quDf1jOMGGJubYaCyA8egeoHU34kX01IWlsJp5uvrEPARBs253vPfECUk9XRkQjZELknnJcfMJakc3y1jd9Mb3uFRthuM+bKzjv8jhz4HkhcViRVNp+Ne86h7Ri5j2e+r6wXA17sa5v4pXljCAm8fDGWoXLN6tnx35u0iz2rkS1BORJczgTnlD676VIqdc97S\\\\\\\\\\\\\\\/8hTYWkrww9pXQsiyRlCtr51O2jdIdJxq+HKeVdLMe1O0wQz5WsHln9+RDoAm81aaOtdH\\\\\\\\\\\\\\\/B8\\\\\\\\\\\\\\\/FSE7tapP+2npl1QJ7Sbx20OX6eQYKqBwBZvtBuB0Ms8wJVQTBhhtzIuHtimvMbN4YLoVCpEfEIH8ki5enXIm8O9jE67j+dOldwMm0BXZvQGulRIPmWeWbjCwAmPzmJUEaHkdz+vxKgq4hpKxGgu34qaDkGUQDLB9F1OIfBkIcounG8LYTQSjapp+CrbfmaxId+RaPLKBNS6HhvhDgVFdR6U+4LX5WJfsuJopTgccE6nXjFjuAiOU9EbZtiwvFIBafAHFba\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/qrbDqSjJWslGhr2QE53EoAcjtHEQpEg4wtVAuSv0xIPtAxQXYdBpqfw4POCoe2y66AM3E396iuuhzwzP\\\\\\\\\\\\\\\/wrfsRe4pTBBmRjlAadIFUCOcuWwVYMtmA0Q0lfsyP1j\\\\\\\\\\\\\\\/qSspL2dXvleRnYtbdxNLAjXj3qCBINwk7MjBeDyQo9V4pUXQoYNsTLNw01aBM7OTDGfPKFFnxScavhdLoUldKZNWvVSnCOlFGJlbWb00BeOKrd2gPHxKo4sDPUr+TA0u+lX2LeC67ttjv+vVCVPBom36GAEHd\\\\\\\\\\\\\\\/0+l6b+Kn8qnsQSgCW5qycsI20U+8FL5k+Zatk8jFfrmAzOOEMJpXX0vtWQmUMB6Ri6jzNHNtzf4uYpOz+i+UhK8HHmz9nemHlUvDK5uXbAcq5nPdS5Nz4kQLUZh0SqsjtKrAhauIByrsjFHOPM7Dhd0G7NY44Js21FneyYL58n8ADklvYXkZL\\\\\\\\\\\\\\\/bF77vW5SozyZB6Qmign59skYGHNLXiKY4W\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/xZlbD6Az+1cJeGzXOW3UxzbYL4+v44fr3Un8G5HhPk3cL8C1xsHGLU\\\\\\\\\\\\\\\/ZdDy7izINNaoV1T4fEx6wKHMIi+AdpfAcMAXbvUB7vXqdOrgx14MjmOro1OG8zBox5RUTdDK0evnywVtR5SRa6f62NIvwrAUbHmPDy1a+KMFcKbagfbj1nplGx9p83eSp+mW7DWb6I\\\\\\\\\\\\\\\/LJMkux0QNTurfUrXzh+Sbu3mV4hPQu6JMewNZtJtculMijQjwvZ8d5IC5SIu8DZjjouMkB2QkLbbLBNnzo6kTDawHnfzsx4VzJp4ooLyFHxqCVVDE8AQuoW4tpRQZEi89UEjeU681cV09ItrI2oWoZxApIwjUtOOk6C9cSnHk0x71V3SPsZJIQ4ZkhV\\\\\\\\\\\\\\\/fJnc+UsEbf3TGywp18rJLLULh4Y1kRvUGOuU94MRA7S2\\\\\\\\\\\\\\\/eWZFHkE2wd6+14073GW8iIJur6+4cEL5gXSv3o3bbgGa3BMTSOOm1m2O4hWz32EkvmbZV\\\\\\\\\\\\\\\/j5+l92Cv+mpnCUZq8WHRiqyB0\\\\\\\\\\\\\\\/kL28y\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/KNP1tHlrCRUwOx06G2h2OL9jJR19aWtJ6AbTgp0M8fo\\\\\\\\\\\\\\\/1yCom7nFsbkF0RI67OB+Rp\\\\\\\\\\\\\\\/pA7xWgRPIx9+13yGB2IbnFc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022eDAY\\\\\\\\\\\\\\\/rAPyYj0FhivUOZvag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b93e6896bf096ea3ff07130a8f6770c419f8a813bfe7e06abe9abeec49982513\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/8\\\/e005147.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/8\\\/e005147.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005147\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005147\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005147\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}