{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RbyYeoAg4d\\\\\\\\\\\\\\\/JOiPR5JZs7Ej+KRsLc+vt48qLQa0wwKgFfgMC04JgeQxK07BqNP9rVD4wz4cG2JEON5xra8vpK6WQJB6SbcSiu+fjllu+Th5TZdjkk8G7Oh04+bvBgEb\\\\\\\\\\\\\\\/qlbWQtPWGgMG1G1+QMdVbYOdyWq30+uqA3Qg3cwWEzIVx8M7So0+NMkMHec8ukEgY2UL\\\\\\\\\\\\\\\/juon8nlkavni8rm4iFC49EW1wAchU93HwoSMCSUv9hzS3L4u8m+IKsN\\\\\\\\\\\\\\\/ut12Jxs7VSn1TXHAJHXyqE7JwQnh95JFQwIb0PZiUvCA98AHkW6wl22HGoVkBNpn8YTAV5JJunHaOtVypMhfVNaNS0Jil3XfKcWT\\\\\\\\\\\\\\\/n0N8hf\\\\\\\\\\\\\\\/758BSIuri8bWh1tPMAapN4rXO0KW7nkCjPa2qhzzt2Vhq4\\\\\\\\\\\\\\\/FwjZkJgRo1mYI3P2vjrVy9EzOTL+UQ\\\\\\\\\\\\\\\/VRM0xXyosLP1rGlfzo7Q8VKhrmqATrH1SsubxCvRWeME0Z53807AzCuGEQePht1SAcZp1AeW9mO\\\\\\\\\\\\\\\/wKl8qp86yPZ7COpQ29Oxj\\\\\\\\\\\\\\\/O8bN2tK6PoeqG8YukHm5qR6tIeUjYjjvOKQk6gJCSpC9G3fU38ZE08+hQ+kEK5LvfYhHAgVSa3Khz2sowYpOOkRpbmB\\\\\\\\\\\\\\\/FNcJRrwug4B6ajJQ\\\\\\\\\\\\\\\/Nc88qdRGNYs0HPXBQa0CndJzlSw6dO9FGyQfOtjH9sUAdAaSE+EAYgmjnDdIueQXEFzFOfkUW4Ks5BXa7tPsHjXpIpa3T9p6Ot51Mmqx+McFcu0E\\\\\\\\\\\\\\\/598du5tAyFHCH\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/iRs\\\\\\\\\\\\\\\/5T8KuHyM4xP6SbKJrxWcs1sRH8v5Ej+tdbQmEQ69HpHD4Cf8rfIev8f6iS\\\\\\\\\\\\\\\/pnZHF4ia3GV96lEcPSEyh6mehrJuQDkB\\\\\\\\\\\\\\\/nu1Vmvu4nxJMDsrVhOy9KgneAb9RYeyMU2DtCvnIR8CdDamVmM1i6+kLEBqauy7PolMaHdfX47s58hXgVp6E0r+SLazF4VP4exTzfIo7fvnQeyJdIdhpbidXVY5G7sQQo1gwjsiNCYMUgxlFJi2kemvAHlsRDHFECfqtBSje7KeueYOJsWydPloTRjvq+DV42eXV1hT4ajGv+6iOhN5l0Tg6bkYEW3ko\\\\\\\\\\\\\\\/DFejhxs4SmjRlGJ5yU1V7aUAHPFScQ2hMswfWCr5PtrJqZTAJ3dyoP9vGwD4SEe6epV5iuz8uyYCUpGFIE6Glylv9qOdgGlBI5D9+KAqh5FZKheFcgRUBITsYVGCmvh\\\\\\\\\\\\\\\/5AwNDg7zB88wp73HIxdf3E+KQCPttJA7AIqvDhiZO63lY3qvmS1RRqKHjgTFwxTDcKikSaBp0S6JBp+hkH4KEtl5A+\\\\\\\\\\\\\\\/G5TMFcH5jsD2leNV9Wjzt5N3Y25fEusRjhlFhOF9EVnGfxsIE1FBFT8PZpu0qsPQYNODtm8W8QR1m5tOx9BBCc+AIq2yslfKKJ0eVsDc3pCwrc5h8M4G94jVdgXbLiUOD\\\\\\\\\\\\\\\/R18vXHtNqn4+FSfAb5eM24IPFyrV9xCsZfEr\\\\\\\\\\\\\\\/UpkcU82aduAEENKUcFaZkMXPO1ViLZq2Ot4WoBtvjdrLNrv0nRTRGHicKRYhXOUIOOmbQC9G07a1Hr\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/2RC47wCK30A1tT3Vu\\\\\\\\\\\\\\\/DpGGSwymUpb9HfMu9a4aiWxS7uEXrmnJQszt6weLufqlzuao+k6gdXbDg15gh6tnto8kJrsmVHL\\\\\\\\\\\\\\\/Xx2h2lka888GTyMg+6dE716GybVH\\\\\\\\\\\\\\\/yzUz5Emcs5xpVCN7KBfUDzPrZ0S6a\\\\\\\\\\\\\\\/3yJAJ66lw3JI1qWmCv+d3dCosLSgedTMz4cUAsPtDJ7NbZ12whhtGbI3VbPtEIsIx5C69om11dse5yJ8+XCEoj3oYGJWwwTe6WE2CWwqDUbgl89xl82nGIlYLW\\\\\\\\\\\\\\\/n+2OEZobnDV5vW5Ho2eoCSjF2KtViphuPE0XNZgM\\\\\\\\\\\\\\\/wxOuGAhUrfdE21WM7X6zk9uQu3Yc3P2OpASIMPqBMtVvxKuw4zIrZoh22uEiQmZMD0ws6GFD4ODSlQcbQgwi370M3ihguwDqHlrAmdSDNyTLtAZEHJ5tCU0RYVFBHYnwzfc+lcqreUdtQk8tCY8oBk8H03T3RSz5CT8FDM2ae+\\\\\\\\\\\\\\\/Nnl6MMuysGBdCdnzwTOgpUGi40Wk9Jcfg3pK\\\\\\\\\\\\\\\/qHBr4ZYq9KrHDfNcZYuMA9SCmlnjF5v+M51mbXQ1Yc0F94g\\\\\\\\\\\\\\\/FOYHnfs9W+KnWPPiKFMdBU61PbBNvgKwHkm8+aM76xiZyTEEJt+uNSDHgLGhx8vsAISH2hIsmI9QdnRVoDg3Z77KT826SwjQTtgSCfkZgOxRHl4cjIDP6oaG8P0r8xVMAhOc3kYPAX3IX+l\\\\\\\\\\\\\\\/Ofq4v36GVbm8J+5jscW0RG7KhrIWS5BV3llHfQlVg\\\\\\\\\\\\\\\/YVZfpnJ\\\\\\\\\\\\\\\/4OYqsn0hof3BKZ1pxosnRu+tFwiFVVAHVtFc615mtwrlLso3iHbloBzU52VSyjfj\\\\\\\\\\\\\\\/PzWBP90th0grG5Q6cKKCI2VzMgBxWZllUYjIv52pmpsJTwnGZ8BtQTETE+U5ubEZEWLRkbaif+O\\\\\\\\\\\\\\\/jKgm\\\\\\\\\\\\\\\/0MRQTJU54a\\\\\\\\\\\\\\\/e57ll5zdqS+vWm+k8tBVo+Cl1DKn2PZxIfIbBPoyIgy8dGvvyNes1idYUHB5jcTwqL7Zrly9yelkS13Uyu9LsJ+TrPLO72PCHPIX3EUsOWQH5nZwuXqOco=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022VDEXhcP98Tz3zyHD3SJlYQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f4d4a74f84e13adc75b6da1b427923dfba6063d65299b6ed598f2bc3b6a77ce4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/7\\\/e005059.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/7\\\/e005059.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-005059\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-005059\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-005059\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}