{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022gRu8jfmUR+XpMg0AV4jOXe9OHIRe5QImtkOuNXATk3oOvcCrIbuRiwLjYSAo8K1B230EJjYZB71QI0gD1NJ8CTiaRV7V2nBCuS3wsvuM9EB5myc5nGDVESFyayfA\\\\\\\\\\\\\\\/g8N1qTrIKrOv2lknhbdksmHxAU0vwWHhK7qIRlikSVot2M6TEITjeK06t9kSFyKRavxCno+UmsiPU6n\\\\\\\\\\\\\\\/ENxXP5S7TAiCJnojT8LmyRMwO4mRAPcW466G9Au4vgIz0iC5bx+EsRJuY5wuAmg4ydAl\\\\\\\\\\\\\\\/r7l5C8RLTGc1vm9eFyoTmDH9mqZ4N7rnU\\\\\\\\\\\\\\\/ohFGhbFMDSk1IBOoGjNeyKXSIjksW+vDngEyGHWd1+hCWlrOZjrr94eGVBJ0i4oBt1PS38dn5pV5AvBMnMwDGn3YY9CxBzkVqtJEvEWZ\\\\\\\\\\\\\\\/uA\\\\\\\\\\\\\\\/Orrwt6RupcRDGdtGKCWqUWyql2One6A2LBeDEHv6h5nH1IWlXDENZqlyDLz0x+PdmNZLP3\\\\\\\\\\\\\\\/svRN6xeWS8Pd8NznEhykfOdX\\\\\\\\\\\\\\\/mjpUzciSErb+eZC5Hz17qHyr5oK6UIgGeHu80W+NXKeApwayPUGxz94+MLkke4Q\\\\\\\\\\\\\\\/OHtR9TElSfZzop2c2bUE1OmdLe5zswTBSbL1Live3R7av\\\\\\\\\\\\\\\/Q4QIcHkiFHAFWb++sp3D8I88DzMVni7XEJqj\\\\\\\\\\\\\\\/XRV4\\\\\\\\\\\\\\\/DF1+sW1IZxYswvHtogtTsiWmFWUbjTQZ8LsMM+0eF+Ynkr7nFePMfp7weL67lFLUF9q144Aaqmtkv0n1XImq4lf9DMNnHxuVqSYoG8AQRUNyaV6j0BMRyQsnvNN2UdqlMdr1q6PRM800yYnX55ediJ9tflze+qFh8RWx0PH\\\\\\\\\\\\\\\/sChXBqL5Mhknr5RTzocnk0BuoYQ2sdczsATJvUL8SCCgFVNBhvZrK0O0Y0NaSq34x8qpNAxtpJ+2Hub0Ft7FpQdFovNPI3\\\\\\\\\\\\\\\/bh4g99YavoLwsj3+7CuztxFdDyimkJ48BgDf3WJq9u3t62bUJzHYvpMfARlwSORpDumTV+yyrMgjo74VjXoMY+JBsJn3Zor+ZDKpaURm69Er2cpSF2W\\\\\\\\\\\\\\\/Aasdma7EzlN+VVgE9imX761E6PgVvDobAAHjGdXDyRSPaANeaECra4HYi5r0ED+0r21Lk\\\\\\\\\\\\\\\/7aKS31shSvEvUG3Twt0TXKDpz5mquJ4rDzAFEytJe\\\\\\\\\\\\\\\/coxMctX68qs\\\\\\\\\\\\\\\/OsZ2YlsGxaGDzCDMu\\\\\\\\\\\\\\\/XHuUk\\\\\\\\\\\\\\\/1nkkiRZnWeUgOAzS2c772p3TxprtdoPE\\\\\\\\\\\\\\\/aPSSRcCX0sk4kBAXuZc2S3Jf5Q6zYNiRGE8mbqaVcSAJ6XYso8m9rT\\\\\\\\\\\\\\\/YrYDTYdgTgs5urscEnQoATUR6kMEBVOchTb+D0uuvaO7JHMcut78INzQPZChOeI7n2YvkoiHq2IZMEfCgt0x+w1q3S0o8ArP16kMEsyuVfwknfpPV4PGNvcQ6JqTe9t939A5T5wBqrFKKDRYruXKddUulElMEp+jj+9GSwGPQelyGbLScCl2vK1lzuTdjNAXRh9qYhn3eip7elqI2F7mwV93cjp4aJ7SJHSIn0GJOx85pBckdHMNsGQTb698DYSP15lx4DeYRu9r3QZqc\\\\\\\\\\\\\\\/LD1K59k1wMZWg\\\\\\\\\\\\\\\/U3SUVilb3kJDTiDBVICAzRDMuGsWmVI0uuxmypD4V4BESqoMlMomC+CBf0n31MygzfhIznTcEl\\\\\\\\\\\\\\\/91Z3zbhehjWRTWmStVji1YOa2Ksi3l8wMwMOFM0\\\\\\\\\\\\\\\/sRw+ss6Wmo14X0JUEnLidP0RFzn9T4o6bNBlPZj4LnT2xb9fgbphb0VtMhIOmsXSZwiGTcs6qtdf2o69Hn1X0gyNzPFe8DTJpko+75QlmXQFVu3+SazTnuUM3ngM\\\\\\\\\\\\\\\/N+PHFhxX5vorw5d9oUWFxW7PK9\\\\\\\\\\\\\\\/eOF9uzbPN6YL+0w+b6Q+gir673BgQ3VFWp61FZb9SRcof3sUWS9gOlmNL6TleQQZ+VqEw+FWVWETtkHHYWHtuqG5z5PNHzJJUVmBASVZvakyTUcKEaEcdJ9if3stZlYsfmiBfUXfUNWkw4nbAhpRRWvq08JySQXvoTOR2J3gMkWalms0vaKPLg3YaEi0Ca\\\\\\\\\\\\\\\/713ORqr16U8tS68wp6aOqlOc1ignOMNBHeD+H2SbHj68AStvA70J6HJnsXAh9o2Oxjm0i4NICTqko8XYYzOfC23rJLFI+WQ9vYQEiclYqzErlXz3m6tbh12vDQ0qWTbAt+bMe29uP1k6deDlGl\\\\\\\\\\\\\\\/ZK3pvLxLaQfUNaz4RtIsHXquWBQxKq2D8IBcKYlIiyix0wHvOLiLWEzRM2mnGUJM1l1nO2ILku7zw7ObkDO+bmE+PJryxAEswogQ5jZC0NerFrCRCVE+LUpTtbxjy2EDojo0UF\\\\\\\\\\\\\\\/c1q0V7kWQpw23NwGKbFM7l4kVEThenjcowbKex4uyR3azB893g9evmU16ElK4NJzSTuocwcT0erqg\\\\\\\\\\\\\\\/HAowCEEkJNhyRQmcnbMWrdr\\\\\\\\\\\\\\\/RwNuy6r8XZcD0C4tMtmve1PMLIcEjad1Q0HN+lsZE+Z4KGiV4FnozffGjZtL9WMX9k6Dw3fQBGdMiJ2o82TWd4TmZqHoLuVelVQ3zmzyZiUUXxuhM+vUuoveI5HMGHBnNJfXMMfGyHeI1dVhJPCZjTqbV1OO+fX+Ccc+AaxvD2lhKV1djX2\\\\\\\\\\\\\\\/vNhzvGgUpX7dSo=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022zo4gN0q70PImXIveODHsqQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022833bd685f5f8995ff98170af504bcc69bd20ebb1a28ad4571514261bd5443537\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/7\\\/e003750.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/7\\\/e003750.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003750\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003750\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003750\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}