{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sga4VFP2BANJ3qhWZ9awG31m3Wr6EJoSCoJv8jUH5PSZNd1bWiO1+gNi3XMAbuwoyWzvya4c2FxWYnCy+rCf69o\\\\\\\\\\\\\\\/QtZ0nK\\\\\\\\\\\\\\\/d7P1PwhS4J6PkWvsrpG05Li\\\\\\\\\\\\\\\/ZnMcPg614e1cizGiBwiRAgpgLqFwu9VVFoP\\\\\\\\\\\\\\\/aqiuFrmV3Hzy4+oNNbQFzl7XH\\\\\\\\\\\\\\\/hTlYRyMaBXM0dXPmd+IZBwBh2KrG1tF\\\\\\\\\\\\\\\/4IpsHff5X6jl9G5tySIHIiAHoJWXca4WUcL+FBC3O14DjlggEkiT7BHrzeG2l0N0LMr9VRsS3ylVhZqTLvtaHwRsfLudxXFL6X8AAST0UI2Hk8FX9xOthLl4Pl6M+xkL6mH8Ksz5uHKDmgmbm5CGMEFsnhLXrzfRhWpQ4wpWBdTuqeaYhI6tTyHGR9K0SDbhpRjw3Y3gqE6rFu3ZGOTnHJS7VmGGgZNtdNqg3kxHsEDcJFYzsLN5IFhW4YVwW7+ikXh4iqPzjw1V+bX8+HKQP4HT94RylTtFu2zIcSrhWU2Zo+PDpVI8dt1ms9jLW7Wk3I+ZvGPnOEGDIZZ\\\\\\\\\\\\\\\/QHTs1xQiH4Akt3MmJsnZ1AyILPj+PehFHpHay51l0alflBBX9i7\\\\\\\\\\\\\\\/2NNEU156fFITT+sSAjWLFurA+k7C5VXZXNK0Po3ItfrA9HA++83j5fObH0\\\\\\\\\\\\\\\/R8CNq7ImiHK0NGtmhavu9GFL\\\\\\\\\\\\\\\/ZwFfsy9SnGB6XE1Hy6bXOaqP2DdSNNFenyT\\\\\\\\\\\\\\\/3WHvrBbUQeEs6qOxvpyIBt7N7N6GPmoN\\\\\\\\\\\\\\\/CRWPAc9+42sSBuJ6bhXvA2UNoMqHiWeQEFTDnz1XOhxnZI9owu8NHJmQo3xJ3SYj8P\\\\\\\\\\\\\\\/QBVYdHoA+pr0ekUCYEkRZQoVXfQoKZ7dy6QGQRWJFdzB5qvbIHszdj057GfjU8NLG6vk7m1yLeE\\\\\\\\\\\\\\\/StguNezVUTZ1evOwFqYrcX0cbOpbaY4uMQWIaiZgEW9wW0BUKkbv8oT3yaiw1GneHfdMk+pwpPmeI6c8p4nA0XiMtWkwh7XSYSopAuypzNBbXOTV949zmsMdVTdS3\\\\\\\\\\\\\\\/eR+7B\\\\\\\\\\\\\\\/HAgfhauipNL6bv+EckBnxzk\\\\\\\\\\\\\\\/Ckw5y4uL0dkn3fSHixEKPu3t1cboPTYVpgsxJdqr5HdFlzkzBHOP9RauSVpYnEkObWUdEWSs\\\\\\\\\\\\\\\/ACjdL3ESnpbQFc88V+FScdEUA9RK33OTLzpBAsGCrEqdmmB607Vw6egcunQGoB2uuBGqiwsSDQMm7YeP8ri5dFyg6Qw0KnR9J0Q6qMbz3XWaUp8DzLDGZs7iJRDmpJ+I3\\\\\\\\\\\\\\\/a3Pnd9olkMcdcOOdmtYSUfupoQmCAXBGcEFv3+EfC9hvi+Kbf9F3ZeWP7icbxNGwUxa+p\\\\\\\\\\\\\\\/JUTmWnkgapTcsGlY5Qa7T+wBds5jX2xq9bZtznctT6V45KZe67D+LEH3LRQdKTSeoJXgHhMltzN+GuwT1z\\\\\\\\\\\\\\\/9iPKl5yLemKl94cTJXZ5Qj3m7LTxz5zYl3bSBnwaSePxkP9wRVOnMqmGVQR13ixKDYbigyNbAjCoj9CXbz3LwtAsI6nykzpSVPNGZB2oD6b9MxDju8Qe1Ws5tPAjUana308ypKSu7TP12761y\\\\\\\\\\\\\\\/IQHmrk2H7Ft9UPLVbey+u4uZdMKX079eW913pJm7+c+ApomiOzSS7\\\\\\\\\\\\\\\/wxt\\\\\\\\\\\\\\\/2aKmlx3i+jCjBrruB\\\\\\\\\\\\\\\/Mp72tvZ\\\\\\\\\\\\\\\/lktAkvLLTmYs2E55YyrxUsXzNk1wYojJEkJmGCKIdLaLmkc\\\\\\\\\\\\\\\/K0s5oWwgw8HQkeg6UBKoHhazcBb9maZNzBfv074RmmllLdXF6r5v5tWw93XmhxrpobWYVT0rHQM3Qfm+YBuMYkmpnjs+oAXyHNZDgHPm+VeHcaX3ToLpBngTvRdx3mDZNHJq+RIsfQrzGeK3sypcMe1korbUEj8Zi8R6ZGEPajXYFHO1GP7\\\\\\\\\\\\\\\/Jo\\\\\\\\\\\\\\\/xEneDop6D+ohUrWTfOw4ywfkHARRr5Y6aD857hJo7UJrSdBVDEXJFis+ATjybGjp5ABG+n7iEYg7VktXU3PQGUd0SKoBGk\\\\\\\\\\\\\\\/Qh+IX4M3MC3YVO4eW4+YF9iultkBfRToG3JY1wwX04nFloWm8paSlFilZMXqQvOHndtYUqW2rH8\\\\\\\\\\\\\\\/zzMWAiicmZd82fQKnsD0OmZH\\\\\\\\\\\\\\\/MrdroDhtQqGuzJ+ztlEvb2DLOnp57gU8gOnSbDpCQHpwyTE2bzerZm55NvJdmJ8bplzpYMTNne8h\\\\\\\\\\\\\\\/yVj25kwymgzHYDqt3KU93vcfDCrGD\\\\\\\\\\\\\\\/8fdzmpFE2majEw4Py9n2oCgF1U+1t6mWnxQfp6LRCZvJKq\\\\\\\\\\\\\\\/qnDo99Nw6fcyhfmd52PXrbQNv962ND3BYIHtx0tOTUvB+HK4uyLDdgoAN276IxQt0SY0h8TJQO\\\\\\\\\\\\\\\/032psYvCd6P4MPY44UMGTUwSElvcppUZDlLZYQ7OqtLFv+WMQ+s\\\\\\\\\\\\\\\/rd0lOA0ERgnKoEMkAtcTrFeghUYZgvSxgxyxKceeD+pxSsKI1JP75ievnk9Gf1rWDkw4FqhKodgvWl85Wh64\\\\\\\\\\\\\\\/QNDkol2DlK35ePWOXa0iYyFnBxGp4gI26SefqBiJaYOVQhxqk4ffowMCdHxOW8ycr5eZxS8Uaht10gXCtZhZxyN+vsN0BYX7WX8Ni1boU1l6f+BkX4uU\\\\\\\\\\\\\\\/k2qd5lhV4KINq6dIfmtyrWBr38glOMhLTrblxHcFFM\\\\\\\\\\\\\\\/fgymtvACU\\\\\\\\\\\\\\\/M=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022SjNk\\\\\\\\\\\\\\\/8H7KNKgicCTcAHjBQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227d820ee1fc1d7c383517bdd7e8d10993b2fc9ab1aa691273b785e644ad2b8328\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/7\\\/e004579.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/7\\\/e004579.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004579\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004579\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004579\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}