{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Lc5gOMOvMFzWIladUviz62sFLbK2hDw0yViWi+l0pYHvchLbItThQuZGsMCWBge0vi3fT5fTCEjfzovuzRL3+rsf+s9iYRWNkI2Jf8wk8V69RLFXLshnqig3wL7S5CocqFBtbcoNh1\\\\\\\\\\\\\\\/mpe+Ng6R+KNUEecZlaxzgBasZduOru1GMNifZCUvVbg8cS8efPikB3fVydyR0RiYjOeQbM19+jJH48q8UhKISes1iNQWDw2HdEycfoUjV1Q1wwOcK1YbGeAOSz4crusg3SjHbemmTrDk8fx7KLxrAPRfg2zrKd23pCFCNeKIrT41QTKB9QwWCElRPgfcZApR+JdwH5cytMRWB76VILniB4mUGREFuqKYVS9rzEodfwHbjlJjjXwnQN7k0HDKvCe6kl9rYMsizRFcYyYg1P5nD1FRJVKR1R3k6NSEhoc\\\\\\\\\\\\\\\/kpGH\\\\\\\\\\\\\\\/A6tG6fRFuxRAoYLbpujwAtdXyAxDlCuHEA7SPqarJNZARnOwNL1DWu0g+nix9s7EpKowp+Wysab4\\\\\\\\\\\\\\\/UgMhRJJ0JO7YKwII9yotCb66PYd7eJnbC65xFCWUe7a9yjACulb\\\\\\\\\\\\\\\/HtKTrSS10ebgKYxVPUrYm\\\\\\\\\\\\\\\/Mr2RS1kFJsn8\\\\\\\\\\\\\\\/Jose0u7EBs410ysXJLJd\\\\\\\\\\\\\\\/1075VxaDySbvPl2QHLT9jJ+nkmoiWN0NCaiklCkHOdDsR\\\\\\\\\\\\\\\/6YiX9AQK\\\\\\\\\\\\\\\/t3UmHcbazMZdw0JntjhhA58spbyK3TyrCCjJvf8f84Tfhtd8s1Io68kt4CKWmI8bI5SqkY6+pekxlAScscReVaLtrm+EGXj12CN6ooeieWERUnmHR0\\\\\\\\\\\\\\\/zjzRIyeuJf2R2nwYsS\\\\\\\\\\\\\\\/UQ2LMRYrDgIemBxWVEt5ncRcOoD554MMyNSZL1Srw1KAmLNwj3mhhznecwWqHq60eCnbHFkAjsXk0vsKxndUmcDUKzH6JQ90XXQYK0q3imtlt0l1j1uA+l2mq\\\\\\\\\\\\\\\/0IGdqKKMK2X7Ofp8t0cmu66dqjcw8Y9b36o5PgnAMyg2ykeLZRfIhToCktQmlRPRwsNbmh2zyuuRfmSOlXJqp9uBOUumxBjWhKCtDbu6wvDQMeltSauUvjnasJuOcClrVJxZrKbfyMlxGYOIjoZQHnl0b0kzqo7V+MXrE85abHHS5clPBY1nCC6vcUQbhpEiHaUVV2jmwKf992IXZ99gsa1NmtKdgke9heSF\\\\\\\\\\\\\\\/TJXUrJKC4pcwZeQdenlA3APW\\\\\\\\\\\\\\\/IQyAin9rq+EgGOwEj4wBny4pU6DrqCmbkV2BKTNaZaa5PHLRpODu1DxxQq1FDRj8TVM6y19rZEEqLiiJFKfoTeHsGO3QCpTGk54xIF0qik9q7Mi6XPPpD8zBKh7c7\\\\\\\\\\\\\\\/Xt47wrzrGSJPNDIPHiGX48WtQhPFI9HF1+hxjE11t2hXf5n\\\\\\\\\\\\\\\/kjmNp+1y9rjo5z4M5+PyX\\\\\\\\\\\\\\\/RIQcJzOYXpFliwig0tWA19sxW9eFD1iSZGZ\\\\\\\\\\\\\\\/JZjZWGi6DvzoL8u61e4X0OwTKI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/8LG8Irx5jrfCsbUl1JhVp6nayFF7AnGVnO\\\\\\\\\\\\\\\/2IqBaylqecGyrj43VnD\\\\\\\\\\\\\\\/S8XBts7yWDquTxEGwbKGSRwPcPTdJALRvRSqjAc3X9tOjPeEgOUnQqQEBOef+3o45Q3tJ8E6nA0WOmQu0pB3iGmXLgH6cwUZAmKaL97GZEScIF5jXwu+DjNpN6+XxJXV1kY2jgp4k5+s4h00CsvbDP4J3qM4wCAbO0tmKvKC04J+TMhagUSbSJ+N6qhwCPn2KUTdmmY1F52fxamUQUm+gL+sJpfh8nrTA7Lv\\\\\\\\\\\\\\\/kko8FofxJPPKa2j08W4dsEgO5b+zJ7QoMC0Cr3XPg1Ysdf0v1ELekvuj8djNmRl39av4Jb1U3fQ+rZNGDUMwtbfPnOWCUvPsxvBol6ZVOJ6MQXswcOD838lxayW3HDes\\\\\\\\\\\\\\\/kfAmjqQHS4xiDwqmIokLDYCuPk11v0O1HziZTQzC3F1+dyXDGc\\\\\\\\\\\\\\\/9EkoWDE7WgoXq0U0kJeiIhSUaOqGPGSmK6o9i21z6UW6adCwyKvkIdI1Bg8jx0F9T3jfwHUhK49WG7nagkm6C0B9lxRHq3yfeploVYSfXQHnwHG7KwVS28WTLcU+b7XTcLqJbYOHm5CMDVZMNV60ZK1\\\\\\\\\\\\\\\/fHhZhr6PpUShfMA2hXPp875apaj2e562D+P2tuN9CjZRhMOxUWJ+41ogmhaquA1ArBMEVWad4fGffeUg+OzCUhuuApIcntyeR2aq9QEeANIBBXDTSuyebKBbnYGXdoUhXLPttDlLnmMi\\\\\\\\\\\\\\\/ZtluZDOss0Ol+hB3c1k\\\\\\\\\\\\\\\/W9Q58C5uCvYaC55mTimUcYIGs54aw8ig5rFNRVs6\\\\\\\\\\\\\\\/BgxqIpVMbUhRf8NKTMcee2ElNT9VkOpb6SyBBkYYDytCHN2jrhLAKSfpO8VVJLJLFA0oUPGG0TuxLkDiYlL+PMjJ0IAqPE0\\\\\\\\\\\\\\\/cIQDmG7rz\\\\\\\\\\\\\\\/wZ5ZNIR7HOFIjMOo2IcYnPPvAyz5JeXUdgPMVEepOmZIaUT8r4GmWHx\\\\\\\\\\\\\\\/VEVsk0JBowQjXjU3meLEPSDwf17Z+e9nGpANRXK\\\\\\\\\\\\\\\/x3wiBUmGWwKxMia5Y8JMQEzyRxuIe5Yq6Q1sTp3o2G15heylUYVMsSoduYYlw8wT+tA9k9uPs2R962Gg2RYqDsX2q+IgxNZUzfzww\\\\\\\\\\\\\\\/4IMpzneOwVe4jRDHGd3WicYnCMyIjgA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cjRZJrRp18oVxGznjvu0Ew==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229fbb6171345d8eeab0508b5489de090f89ef34b8def3bd48e0eb2a14ff73276d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/7\\\/e004464.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/7\\\/e004464.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004464\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004464\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004464\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}