{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hcKdabRXcXEwCfpwEemeb2edjD8Krvd\\\\\\\\\\\\\\\/MUYBF+D9NtyJ2WZBG6e1tx\\\\\\\\\\\\\\\/tSUJrTZsDefG5dgSvUYe7ki1r3Jcidw7VZL+L5qus+b9LXtfp30hBfN9Q20Fpr+wqYu6vd0Lbcl7txltnWj+jAYPEV7s1QWeGw4jirSDu0hZyfhEyLdjSkiQBTMl1SjsUT+Xci0kPYQk2G\\\\\\\\\\\\\\\/Gw1lWa\\\\\\\\\\\\\\\/A1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/o5lrbH\\\\\\\\\\\\\\\/FQBWRIjVrmDacAfgt0tNkJpYAk8MPqsOkROSH6QzQLRjAE4IyuejqU4KKvfJxwTt1Ooad4JW93antDlo+6bjGSq0AHvkhllF3ZtkEMardjsixV0fc2PnM4s+3NRS2sFkwmbckriusxTI4sOrZeIdAigavkwF16Zk9\\\\\\\\\\\\\\\/v\\\\\\\\\\\\\\\/kRHBPakTRYhyivqCBCEobVOcfIYcENFkEh9HhDojO2LJ8zh4V8KJgo9X9vZ7w6MpSCW\\\\\\\\\\\\\\\/yyvHZ1ifxsd22jY63ZBdlmXtjeesvX3pQfgyJ2z8IIZehOt\\\\\\\\\\\\\\\/XNmvbZ52zXfV8RNWwu2Nu\\\\\\\\\\\\\\\/C59AiqKg0Gv0UePup4v9tgXQYna7wTYRgrEKaj0\\\\\\\\\\\\\\\/bnN\\\\\\\\\\\\\\\/Xk2NL67xSuNJXxl\\\\\\\\\\\\\\\/3ML6DAlOUfdQIknWbnNBORfdBw\\\\\\\\\\\\\\\/d\\\\\\\\\\\\\\\/Lep+Q+pWcjd8rkfxhMf8wulJpnbB3ZbjQtzkxqC6tqrr7KYcSptRscaXxQB53MX+ByTuA4oIc2RIs31Q8q6xA86HRHCLYWECRzkEdyRcIRbrx8JZg7S23Bo63a4YllFEGmGlye6JTfhcVh9ernNWJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/rSqfZnE8zohabwlb9vYSZvO5kji+HV4VEXo8R4OMLh2o8zWqyYh44EdRlpYdcmjhAeA6udJU6wtL6hV\\\\\\\\\\\\\\\/mUIOIMN0pDOjHj4kgRvimxHaz5WlDQgDNqFFvt39+T6\\\\\\\\\\\\\\\/MRQ8aorPb+tcMjY8vutb+5RxsLmFvX01hYn5slUtsbPu1bQCReEfrgBUZkm8bWJFDszDPpe+YiNOjG8M9UFbGBLij0nNndJHgv8rfhR4mJml6nhYhT9B5PuYCYSoETZ2MlNipERS6bjk9nQztnRBQaZO5HACYk7T2cAouZhowWwxQF\\\\\\\\\\\\\\\/TbCgLUQwiX3l+CmCl2G1m+iFThPSEEnAGhvc1tIxz4SVhtdIo7HCeqOQSmNS443O31B6ivxcfafeV1crbY6WD30KHENI3ITxohJP47bYQZS+xnjzGGgQlY5WgpTeO+zOGMCCIFnqYsKehp4O45ZjLOAwUcYNRDvQMPU77BkKZm2skwp9Nfz29GmTU2m1lTSkLv5gqwo\\\\\\\\\\\\\\\/FRWLxNvm3wdY2vRItViFhDcJd77SVL9rnZGy1M5oAV1\\\\\\\\\\\\\\\/GEixRsE0Iac1PpUr+EcCTDvHn7DEYG5OeN4oTxM6ESu4cyosiTzP8+5PggXGtvNs1euKLmuFTEcCDP5iYlAM4cMq5Gt0If8BMvHEtX+hIlwqCUU2AxqTFQUYc1MIVX4U9+icGUssO5z2lPNwF9mAckR+ZilRHbCHukuSHsaPkw+48Ovn2grVPQpYf\\\\\\\\\\\\\\\/b965pg+bkJiGLwgemmGlPsTMxcJQ6Qhm7rb7S1w+T4qocrYsRKiRgTkEhAslEPHqdiToIzkseCY4WQnSA7U1lqMJUP5rFUStqfICnr\\\\\\\\\\\\\\\/bkjxRFsmZTcMH00mmg0IKcrQ5tMrViCzuM7ISP6v57\\\\\\\\\\\\\\\/kxYoLQ1VnPpIagDhmVrJTrLk23jHzoB\\\\\\\\\\\\\\\/Opd6AGQfbBqvzly\\\\\\\\\\\\\\\/E6T05IgkRCPR9YiV5GnXmMowMQwgskFwnwhqXVrPDHL3y6nOo3an7oP6pnDosyDDHSc0gYZI0f52oqpHyY\\\\\\\\\\\\\\\/NqNIzQkG4WTuiEXnIy0du4sTHRh87x2XfpLGxJ7bvg4WqDMZOJuNoHehhHVZkGEdHdYwfKrQaZXtiAiHDMIJBeF78p1N0MdIsrcP9n19nhckjZiPpPA1KOtzRTQi6vUsQgPbfgKU\\\\\\\\\\\\\\\/QpVDr0jk95dpiEcGT0I6H0BJpc8JBTSSy60Q4V6LQ9uv2YfQtXciyMQd66iCoeGMNfxevkfpFYKtKNR\\\\\\\\\\\\\\\/V6YRyx+RbOMECrUNgITsnWwTt+noGkmAox+SIK8Q6odf5rWfuwmYb+BJauNBLUbDzWjXnfWdaow7ExtbK9X9BHGX29fEmYIN8bRMOEAqCHeprBgaPgroH7uDqX\\\\\\\\\\\\\\\/mA5Pgizv70IBZE96SjpJNMfGgEDn+TcEAYXi4QtlK6GOXapGFjUS6RrpHkBDrlja4Z34R0f2pPxDnelz\\\\\\\\\\\\\\\/UaBqmqexOLEy3Dt67dhuW8j1IBk48bc5UN1+hMcIBq7lgdcYsni+dbFPFiD5YY2\\\\\\\\\\\\\\\/B3LQ4WbJRlIVdfjw0DTx+rd189gC6RDgeAP5y9QpmHu9DQOFxuiVkgIRCyzTSZ0s\\\\\\\\\\\\\\\/RK8sidgUZ6HzyC2zyvvHFWUmbJnDScDetlwYfnr4Agn2DfrsR6jKBBo0EASTYPyfjcVaOIfKwVqfWWMzu0hg\\\\\\\\\\\\\\\/T3FWJhK6KYIqUudxF5NAMLkPxmKtkAdz35GkA9fn2S9xelCwBZmGv4wsbTdCVd5HjhNR\\\\\\\\\\\\\\\/opE4dOmSMqnTVwMjDLyjxx+4P7Va8qDea7tyekOYdqCNY07izYSuOF8exb0NB9\\\\\\\\\\\\\\\/fzGY7j4Sq9X2F\\\\\\\\\\\\\\\/T6L\\\\\\\\\\\\\\\/cVO+wUClTPvgt07kku9Wzxt01tLq20wsHCeBEvdFraTfmoSyIFa+pY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Qs6mcU7RxC4hvdKe6uokzw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220c7c9db77f8848fe4f5ca2eac9086775b9d80b5e0c2e6cddde5b7f72fbeaf842\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/7\\\/e004037.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/7\\\/e004037.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004037\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004037\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004037\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}