{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mWEqtJFvFrqyRXc0TP\\\\\\\\\\\\\\\/S+7qxLxc6pHdg1B\\\\\\\\\\\\\\\/62cry4d+x68lyqTEy\\\\\\\\\\\\\\\/ZvhOc1ilarv3ru4vrYz5\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/+IGgATnQGg1bkJIECAwzxGY0KizSy1AGXs8AM5WfXtpqLsFK0nxF3+0KsqN0lD8\\\\\\\\\\\\\\\/cyCKz5E3J2uHFC9LhgVKwx7T0StyWc4vYuv+nKkvDU8jKCdMBKyxczQyUEYlGH4UNku8rRZ6sffcgC\\\\\\\\\\\\\\\/qGRneHZSJcGPio75S839k8Tz5Zh3kFwQdGjVq3MUNf+WOzFSZJ7ULNbjd30AG8RBhCO1fc6d0z9tIdNJuHg6Q4qN9iGKjIEPf34fb+cdajbsY4EMYGEtd4fwmIQXVjpMhRK4+4tyJcoSVmCXpHjWIfp9WdXhOhbumcvMXRoJfa9aO8M3S8wSaHCH0FBGIvDNGuG1JbTBUlMlaDR7d7cos5TZKDRCcowaBnVidNZslWPruNcIDEm1cFYNdjmYn43Bl\\\\\\\\\\\\\\\/diEbz0XohEI1sYgx2B3nES2NirWPgusZ+u1gTiP8GHa3GpYti29yZz1Df2woGNPbYGuPR7\\\\\\\\\\\\\\\/fFWXmxfPmaJ\\\\\\\\\\\\\\\/LQ\\\\\\\\\\\\\\\/8iP5+yDO4upVm0l0c+qmoersAaTJGUifPIabYk6crnI2X3JCMfM0SZOnE\\\\\\\\\\\\\\\/wpprs\\\\\\\\\\\\\\\/M6xJRijDufMiHPNLkO2eLXOhj5LUNNKcugJtR0XJxGEMU54nveYCjlGO6SI7+8rwFBwjv0dst3d\\\\\\\\\\\\\\\/d7xrXLWW8UO7bD3KYU8zTd\\\\\\\\\\\\\\\/eRZfinH+Sb4xgMgSdkYWeqJTq31COJaUSn5m3u7KmqhwfilLgsL2Ze04v4R5s6Uu7oEPOkEEX+eVJHGHIhvJP6y5pp4hbT0E8gCJnmoj\\\\\\\\\\\\\\\/f7nX7H50Z+3p2OtnEmooyZdSvYOVdL5cl1NOajIoTKhoEXCqPvoGDR5eyk3woCQaBmO0WXNRqjUYI7CsuexaHWpHTjBnxtDDeT9fBQsybs7y+0u8sJWaGxFBG7yJ7fRDIVBsTG3Bw8PGY8\\\\\\\\\\\\\\\/guMwpbWukxM2qXfl4nmHLCXJx8lP2HKKg6e85Q\\\\\\\\\\\\\\\/1ktvVrGd86E2aJxGzHPwwR3GtzN2NnB0ySvXeH+FUxGoYRy05qjZXPVmjHdFQm0La1CWqthYPePqhQx\\\\\\\\\\\\\\\/WChlf97Mb7or314d0EKYQoXagcKRWXpTMua6PXSKyGDxSfM55gk0OkEFj+0kdMrMkoFy7sxp5+TG5rY2ab8budoMqWpbGwozVMn8svOctmv1ek3RkTeqiVfE\\\\\\\\\\\\\\\/XDr2myiG5yeVUf1Fd1XSkDTdvNSTDJkA9yvWNJUsLw6KZp6AANc24b1O7lHlGPXbDlr\\\\\\\\\\\\\\\/I9+vRhxyMtdCTZeF9Cbl6Ob6+Ihb5cw7mQCoyXfJKYRdDJqGaH4mYLnXW5I8WhKmiox48ymxN91bsFCTyyKPbuXUaR2QTuNOrocO2KOkjWHeUOE7C+pyop6eqzGm3pw2Aq2zkSIDYfuiRfmgKJ7dWQ7y6qOys\\\\\\\\\\\\\\\/8CewD3HBMSiNVWBJkOYJzrJ87\\\\\\\\\\\\\\\/vOvCmZFaStN6ftJAgj5VSzRDCbq06H1B2Ir4KgE8oHT1AvZ2Q56hCZMtiKlk75xA7U+SNkZPNfUXbOpWErzQ\\\\\\\\\\\\\\\/uaLE4GZd4Xy3Mq4FH2cUhbICc87rLny670brriC4Wv\\\\\\\\\\\\\\\/4qIjyNDaqoofu8Q04LWXToI3peNkvRnVdePioLWhCDKX0m253SKn4cNuYfe5uCb41WygL5Z2FOE4JdvpRWtAJzNa8OUVGXNjV\\\\\\\\\\\\\\\/9TrHJPvvYQ4Us4b8UzQnPXYVBWxs0l9roIMcanxdNT5q440YZ6anrHkI6Rgrl8nBMUrDjqNedydCL11x2yXZ\\\\\\\\\\\\\\\/E+Z2PBYZclgTMMF6EIRA0SAc7DdyZRaT1DblcU6cK+LVcGQCwhqOrK8s85sCdeba3XRSRgxRn3qECx\\\\\\\\\\\\\\\/qlVhVy+68HA8Cvns+rIz4OG9NsKbvy4jW3V1o6MEvWMTUrBYSBIVDKozZ9HHmU1TJ+E+6ZyAVtOAHGSfJoK2bGEFJLnjKLgk0dx2rLPMRBCaBJZyMRNqwxhDFDaU4bphBpNdpA94+LXTloNyrHJpQN9l1dS+rgadpzPDD3nNfKImlDysVPbCycBP8dMT1ytYKBP\\\\\\\\\\\\\\\/DHgPqzg3SpY\\\\\\\\\\\\\\\/ddjY\\\\\\\\\\\\\\\/v4z+0FtIkSqHNRwVnJHNfmbfJVNFfIx4y24QQdP8vrF6fz1Kc2Nox4j8pUmzl+AV5Nws9A8nJRbSIfnY17t7BBfWT3V6Q+jZTUxi01Xj1Itq0amXgbpI+mOi1K9xGVpuvY8y0He\\\\\\\\\\\\\\\/nQRY9L0vFlezAbPQ\\\\\\\\\\\\\\\/gpcrc42\\\\\\\\\\\\\\\/798rrWVcD7mDhkUZZ\\\\\\\\\\\\\\\/+XvfUQIe2g2EVUhSPidkMXhkgjV6A41NNhaJcdK0GmN3EdHC9tmIvUc5l\\\\\\\\\\\\\\\/44I62tVlyR9El7Mv98o7VYFlYIJeMESAzW6RTCsrnfc7jI2DjwHF9VC+IjZgE8hixHq9YAFPr2rwJYLR1w4L9U+QuTUXVxj4gKPEm+JMS9fxwgfS27cmolmZgcWm4nDHZSI8MQ6QhGP0YQpHQ7E2Vqn6u+tMMX+jXX236qsDATGAHIzkfvVW66\\\\\\\\\\\\\\\/VoD0gOVEro1wX8eaCPiEk2fqkF4ZvYCH7Ax3\\\\\\\\\\\\\\\/QOpcaMsBLt43FADcEXpxzATGHTLVyrjYbcHeLMWQJe9ll9o6VZ9HGteI\\\\\\\\\\\\\\\/9Ebu71+QIMAA\\\\\\\\\\\\\\\/c7+BuV\\\\\\\\\\\\\\\/E=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022STnT6ijUPayJ2oGaMyTcWw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f8aa885c8ab7d90708698dfda4549c9de274ac9fba113ef5df83f68c3ef5a4e4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e003811.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e003811.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003811\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003811\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003811\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}