{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hIm3YsgVHXSDdfkC7xzoLvBSA9Aw\\\\\\\\\\\\\\\/Mt813CVVFDrf0dM0f1eKWdKG1+6V8hNyv4Hi8BUBRsjns1flhLvbn7UYkx0qKrDDARrxlNpTKByLi0+O5qSO9hzdQXCS3KQzQiF671GuluNt0Nuj\\\\\\\\\\\\\\\/bM\\\\\\\\\\\\\\\/mNSRyVJsoksauveQE2f9GenfNjDk8jKc9IEUE5hDVEpROQvmC15D4v35INzb0vYY6AwiYE56JeF8LkbR03QH0CzdResRcsT\\\\\\\\\\\\\\\/qZ6TXoa4Nta63mfTEyalK1r8VDTiOBbEdTmxBANXhtdew8Vo0EZCPQKafilT5R\\\\\\\\\\\\\\\/y9CCi95Xbhlghjbba9xV2cpl3JPO\\\\\\\\\\\\\\\/PXAMpGAlCyTb66CT4X87o1fTLWZMHhg6j9OfRsT\\\\\\\\\\\\\\\/6Y8HsSoBPulxME7qSNL1GsPKq2\\\\\\\\\\\\\\\/N40sI9IcdIxhIQw0fBU1ZoiWAWfjPJvRMhcAIUkDRxm\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/ZnrAdapDr7JGQCtWX4YeJju56gxu\\\\\\\\\\\\\\\/SyQnMHmpsI4uo1BHKAjNHXl4rt9dIpTvEl2yRyfeH\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/dHZb7lCvCJBp6wnZOdfIsASw1rW90Aeyb0NjcYb4pi3ziBkVNf9cgy3Nt1f977lk5x7\\\\\\\\\\\\\\\/l+nVtnzMu82iBH73yiYeEs5FJKFQg1KyXCux9J6jqot6hzL4pXMeAPPAMQDBpR5ZHThPgK\\\\\\\\\\\\\\\/hrZxxnokSqvOgU8sj5g9a2PB8AU7Ih0MNqaXnC0Xcz2S\\\\\\\\\\\\\\\/cKO0aiS45Vu+na7BVnk11z+BZODdJpx4h9bd0B0iBc1tTQ+xR2VfymTamicA7hhkxVUCnN05g2+4qZa1dCPzpaycBT8WkfsqmKdMxx6GhwccqaKqHqRU\\\\\\\\\\\\\\\/BKJwqdYvI7QNZaq9oLBhdu4457e7Q6DZNoc8uVB+kzT13\\\\\\\\\\\\\\\/QEbeSaQpPeZCivUDBrMPXBRBoaLI789SxqbyGeowcgqyBbeQlpow65etzNCV9ZEX9Kgv2v4RA\\\\\\\\\\\\\\\/w9HAOBTJKRtU1Jog8\\\\\\\\\\\\\\\/VCIwN\\\\\\\\\\\\\\\/wZ2VTqOucEzXoHST+y7EYVEQzpIT95vAy89AddLbv+5VSmH+l+Uk5JhA+mUjfJRyTmj5+opMlYIDZGRqRRfF6FfO9fMoJ2M24Wmji6J81QiwH2tYtxcZ8xKqM0yDiDnfEhu4LeBL\\\\\\\\\\\\\\\/9UJedBnVCL9oK04Sl34++aSUpCQP+qgxyLmCg80ffPtTKrZPyZeE0D0TxuIn0X2HHYmjWrsNzKrD9fFHrTFlorDnjo9SpGF\\\\\\\\\\\\\\\/4jt4gLhLynu7xSyKwcV4is0yzFu\\\\\\\\\\\\\\\/VDSH1fn6\\\\\\\\\\\\\\\/yIm8bHKAl+Bw86faK1yLvMSFqEgHaAei36dQAVhv4+vzuHdhNe\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/ZHT6jOl\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9DKhyhje2E31L7FO5SKmMfTK2\\\\\\\\\\\\\\\/5blEV1Io25eYuKnIr4v0FecQ2BBVM1ysOZIG5Jw1H1iu4lZAEysiG3dni4RCvfIYHNUXvXRmYdl6VPhRXiicGW80pANp+w40lJNvyzn4FBbpyglsP5TXaAn92qkR9uyzDPe7v\\\\\\\\\\\\\\\/OMNwDikGLXJi8gsxr5AojZSgNHA8xlEsf05x1lvFEpyDD5+m3aQOqfW50oJe9sC6neS+BADWDnt+pwkQmIZpx1KY4gfY9VG1olQuOG8rIRC3yrOEuZ5RF2CIZBPrgN84apjjB75tv9oopQIDqimhVjFjx3qFGTkHjexsEom+R5XLEa+1pZKZrd49jzonxRx8faICV+ZPQQ8MepaQ914War3kpSf2Dl71xJVwxI4jcni1M\\\\\\\\\\\\\\\/QHb4upE9vL3N0KubhvniII6me6WBvUCsUBHymQ0peXlckWSkOrLYrallqzGLPwn2jz31HdnBFoz4tEN8TGC5Dnbz3ktkMYyuhvDQB34feaxv\\\\\\\\\\\\\\\/sqxwlrWVt6l85ImUZjCEEZwpF2VBOC42+ndNmVeMSkluUdz9V0ZR40BiYxfOTuQyFJZymVm\\\\\\\\\\\\\\\/8EuZe8zuWkYhnDScevpGC4WICOXqo90NwzxvI55L9cO4UVeg+fN3mkqBcubemyVuGFboUBCVkivwkgIScWlsep+YhNFc4dVa6dI++s9nC2T1uuRixnOfuevEJ91d9QtEelL54ARJ+uThpp7PHUxJzZ26BmJBdvAG0GjeOVNdmRmXq9nV9+uu9n7BR4wyqbTTK9tyix6CCxwZ2MrOfJUNYCinXEXmPVjmgpoxSQ3rRlklkPff\\\\\\\\\\\\\\\/wm3mfmWnTqHyUwoLB2M0XkzgW3wkjpe+4te2bOTbYsu\\\\\\\\\\\\\\\/hkEwj\\\\\\\\\\\\\\\/NraAhYOiRZ+yNM82Gj2tuMZvisLcr8eCD8uAhWWMTW8u4x+r4oXJHLLGVgvgr\\\\\\\\\\\\\\\/m9y4M7wl5Y0IqFSVijq5Jqs7lOgZEapecNnicuALty7XSdAx7P9zBoVr9T4X05wc1Y6GGpjnDaNoEqWFl60Nb8YgORbw+1N8JVmYvDY9JMNE8gd8W770G2f8pCgHOzD0r53n0gp8+kRjJy0S7X8v+f0xWAZqtzPpzsyyegIXz6Fc0k7vwSNgfuujVr+qFCMXXDyEXF9wl28LmdzJUr+sU5pMXcLcq2NqPxq3atp456PXF4BE1Vz8e6+FtdLRfeBQkwBuzvB98+FgBGGUHWaAcRsKtKEwA+zxnc3EWGot35hzewwZSGdeAvdFX4U3CIp31Guq9+h4MonUDsl\\\\\\\\\\\\\\\/ed\\\\\\\\\\\\\\\/BO1JPAhKUVQ0Wd+9bG4mspDSTV0W\\\\\\\\\\\\\\\/AG3vndj20=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kPsXq+VcrvzY4ZEijZiGGg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221cc4f80b7bcf94d671746bc9ab696877deb44ed3e6be5b51d5af85554741488c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e003811.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e003811.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003811\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003811\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003811\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}