{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00220AeMF1yyMtYhs5Yji5+0GHXtneo3CKx7FkN+HQ+Jzxml3AKKc25mhkT\\\\\\\\\\\\\\\/0dKUR8wVoEspNql6eh7p05wo6rDQncByKB6lt\\\\\\\\\\\\\\\/UIAXEcthGUVWvclbD\\\\\\\\\\\\\\\/dawHYuYGysMSOqmpvG8SCzRiMEV411lXa84PkRZs9zu4tPFLOJeOaGsXZ8qf0xDmEB5n0Hy7KTprmtsjzSjmU2u2UWJfj\\\\\\\\\\\\\\\/+REDipBLOgtUxbxC2kj2bv6R+FsLyp3hNxJgyOGtZtTv5\\\\\\\\\\\\\\\/LmIYKbcZiLZPula351juTFMK\\\\\\\\\\\\\\\/x4vi7qTiEtkLDnoGqwzVYNo7ehGrkPTGI7bexYdwKJ+og4MXKG5CDGvmGXcoqg2M\\\\\\\\\\\\\\\/dDjVJenWxSGY8\\\\\\\\\\\\\\\/id0TK3xh6oUIWLaJmNRQK+ooyykyZiUxSoTVA4d6Y9xkHg5acYYtj5vam9FedMPVMcNPKjlOSAYYp6R0tYNSChznaPo8WicJ3bSpbnAb\\\\\\\\\\\\\\\/I1OvCKLg2qD4fR6wzjmdnBCaorFJg8PU9QVXlN6LOiO\\\\\\\\\\\\\\\/v082PPpGrrQXi1nySTjRgRtpUTlqBU2dWkSSFKpD6KjYCl+Qw8MErPi+XuHYQqbFKl4+y+3e5h4jPzBum04NYpsfLEn7ib2DBaYOZnotx+R4QI4avdRzyRVC6vG7\\\\\\\\\\\\\\\/Fz5laca4UqqOIMLFPYSJOA5vVvoaoA7SgC\\\\\\\\\\\\\\\/EpyY62erDenjdKT+TONOqCXh2wdkZKYS8laS2St1drwRpvXvJu5Er8H2JWQ7Hxst9O7rvuhx0vOA0XfCM\\\\\\\\\\\\\\\/lUbwDhQnLqUMSM4yjO+rcX50dUGBLshNVrF3rEmXSye2GhLviryld7ReXkdY4CHs7uCqyCImClCd0odMrjlu5FFsTp7P0dIAnCRWMIpylWAkKPVokds3WhbpBtCor2yHg0sVX+tEXd4QmftryuepcysfEJnmdRlnQ8Pc66zgBHd45IzzDvREyH1Ro0N2JGkREYvL5RgFnWjFiR4OHu54cSL6JEOR6DkpLKo8PKP\\\\\\\\\\\\\\\/ng8+swMGymukJ7X2VFpCnLI1EL7Zb\\\\\\\\\\\\\\\/J6yH22TXAipmGW7Q\\\\\\\\\\\\\\\/wSBLJQybZDeZlRRoi3asW1jMIi\\\\\\\\\\\\\\\/YcxwL67Rb83Bkgo+jO+l8MRSPB0aUpAmiP\\\\\\\\\\\\\\\/tiPMatkEYFnve\\\\\\\\\\\\\\\/PFp362Ko1VNKEHsHtvbO2BEveyEZcRKjLucboi3+DaYTbqzxl6GFQ\\\\\\\\\\\\\\\/mYY2PpLAKyvj6jU0XEGvlOL0KnCh8iPv5wQdO8uZsVCro+2SNyMEBciWsT5lSZuHUF0GmH6lCeRxLo8jJ9sp8rx+UXzQXycb1VhczYdx2CMiblm22cFAZImJnyRhpMALK2H0aZfZAZbrFMNq\\\\\\\\\\\\\\\/XOb+jbfAPakL3jGMxh65nGQztjg4Quy2sbSv4TPk5zhWzoCUK\\\\\\\\\\\\\\\/F+cR8Z9CKm71r2oBl1n4bugfq8tJKOy9Y9KTkcozfyQDcyTPcwLQspO8JIx3GU6zeSytwFoVVIeQNlSF5pfqEf7Fjaa4BiZfzQ8Cly2qfuCGCVBSug9TgN8R1TM\\\\\\\\\\\\\\\/DxT7h3daIb1DEQLt2rHoamLLnF2wF\\\\\\\\\\\\\\\/6hIDGqnweJ8fGcKZR7eP8RrSjcwrm0wNva82vLF7X7ndz8XERS7VyDiQG\\\\\\\\\\\\\\\/2rE7gEzGGjFqsqB5J6NuGR2e07sjRf8XdgKR3WDScaDSumQEXnvTMS39JvaZ9tQmmMyrpjHhFTvkAxi1+cuM9+uJM9msNBnijVIhwNCeuNZ1FfLkPAC6IInuWLnabig+zok9KJdjyo\\\\\\\\\\\\\\\/9gmNIly0NIkqpx1TkQLdYycLpM5FnB0azEhGDXuZd1r4aqNaQnM0kDqcdHmWhldyfACUmqlYu+dJQDAk2TJKeQ\\\\\\\\\\\\\\\/RXGl7Apf4Lce0LL2sqtVwf457m94Mjv8JowjMGkzax3YD0TYEAbSVKRkLll\\\\\\\\\\\\\\\/DumF86O4qA1Iu8qwUQwTnCDs0AF4z\\\\\\\\\\\\\\\/icw0cAVwZ\\\\\\\\\\\\\\\/EvCqnMdrCtK7z3Zyx1Kg7tbOItLg70x+1cS9fOuI12u5+R0EeZgpcVfif0FuxSPQPjHGuWdhZoHjo2Xk3zozQdaW0mSZsRKt+wdE5W6tUVcvA3e6iUSki\\\\\\\\\\\\\\\/cUVqjYnrcfQQ+8iPFlZEUSHldUkyzaHkGUS1YjJl+fweRKK4gub5ooa3u6qRAevVGEEEmHw0QKdUqFKc3uc6pY8CA\\\\\\\\\\\\\\\/2zHQSUFGdxNA2+wPxd9mTnBjoIxoMav7jiK4GM\\\\\\\\\\\\\\\/PuaEy0160QWUTpFYIZ6RrLVqlA\\\\\\\\\\\\\\\/PPIeQFTFmSi17AsuaIUPxOxYn1qj\\\\\\\\\\\\\\\/w2orppRIaQFtdrpMbTqKkRwtW6YlqrabGf9WB\\\\\\\\\\\\\\\/0QfKRSanjRch9BPscmihUB\\\\\\\\\\\\\\\/CE9nyd7HU7VPlpqf4PuO+a0xUitkrkxWBGj40ANEq6ld+6\\\\\\\\\\\\\\\/bRdZdm74E3LwFn4NXPlEWw+S5XFVzggS1W0Qs6S3I6vq8sWDpxYjhZS8Fh21LTw5Yzw\\\\\\\\\\\\\\\/tcGmXCNn9T7PRZISB7hV1K9jj3z8\\\\\\\\\\\\\\\/jEXFNE691CyA8OWWr3\\\\\\\\\\\\\\\/XZrieSopVTbE8jmJe9LO7pv0MHUu1hcbclPtn+\\\\\\\\\\\\\\\/Hq3\\\\\\\\\\\\\\\/EgTo8KOZQB7oOtExQZ4M5GMnDAc2KDEoK5FTqG3NqWUo9sX7fRVdikBJ29OvJx7+kqk3kOZZvKk8KWJBg5i2x0Nh7P+SQfHQIna5LAoNUbc6QPg7lUFCYhAswtQ6HUQYeFIMXHsSNb\\\\\\\\\\\\\\\/NW04k=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022mhSV8Ad1s0PT2WPseMTz+A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b118f72f7c3a05a7665531e41cb3362b98297111dd99b254b0c031e8e215cc7c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004646.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004646.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004646\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004646\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004646\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}