{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/63O3sLk6ovuWoXJFQY6hWpAdtU5xTBLnHhT+GpEdAZJ8rN1rhjUVtTcokjA\\\\\\\\\\\\\\\/oPKH1FB8Wgi\\\\\\\\\\\\\\\/z0H0A3u8Di4MsC+zLQkZ6fdpXTnbdTVz6Qmv5mFg8QTyXzH+BmYa0iz\\\\\\\\\\\\\\\/mH0yr0BDGXafrF5VIuYly+0N3drajW0n39fqUZ1sYeDxpoLDLVVgqEFHB5p9EvgY7GiibqjdPUbW\\\\\\\\\\\\\\\/qhvMwiscjDUjj5Wg3YRt8mrD05N6erd3JBBrMiQZPR+URy0uibV7f1TrRoa2xMmVDb+IH8P\\\\\\\\\\\\\\\/xaPMRmaygUuna6FDNQSTthbRK3VsdVUhj0n383PpEGr6Lx9qXdK4qgovWtLvqj5a0I6rOjKvoxpfAfriEC4+SO55UWflgUufbMlhvSe7BFUHyTBA27FZ8qunViBcQMVjUQtJ5SZCBn51Fng4nrLMWlm5peFl2kgIq6wc3q+yKVA9ewVEYwYMrum4gexbOGDZPyC1Kh6KItFyCYJL1xhILujjRgFdGHuo7SfX8NSfA8ahzmNWCdE3pFKhqO7zh+PZXO55auo4o3FE4GFt0xYUUAU6kzGWnwnj73sfM1Rezotw1mkjgiNmTs3ob6MVA7ngHCPy9TKmYXq96zqPoCYCnrQLtqx\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/eZMhWSdKdiOo1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/qBj+1Oa5mRrEE+eKtfGq46NcuEiuQ4XvM4EhW5l7FyyNvClGi2JJElW+0uExLfD30fc7lAIaAOc0Qyb8gMy4pet3mfCi3ZO5ooxMgf6MK32j+iQMMoEyoZdUvYqIcga8WTQHqfFiBpDab\\\\\\\\\\\\\\\/wOxyxtl+F+oscf7mRcNGMiGmcfY7Yqj7MP2233m\\\\\\\\\\\\\\\/rxzgYVEMP9u\\\\\\\\\\\\\\\/j\\\\\\\\\\\\\\\/vVcFCc0nArEFuGqBsswJzjwzUvfQ7R3UtGrsR5kx3fA5Mdf4WJ2vh4MQnNVznoxQaL2NnBOTL7fTP1FXuhbhdgXobjdEmY\\\\\\\\\\\\\\\/Knfj\\\\\\\\\\\\\\\/N2g413I4m6i3ymOQUYgGG0jzPdM+QiiTGHLXWEd4AmGHaYF1ObEBYaBVdCCjhkSlKK5mp5xSN0ok8MvRpX71u24QSENMo4fJ05BT\\\\\\\\\\\\\\\/o3MIskOoBljIy4UEyYHf9SAjtgT0LHwIPI3GdFZj+i0u9PrkOWQDwvpkMl4cSlx7UZarhD+HhWGr1TbTxTLMKVzqewD72IAbXVxHPbiM7wemAFA2JzLm+T1fwjVVanbmGuBncmgNjYfex9fLLst64h3x38X\\\\\\\\\\\\\\\/Pz5OmjqCxsabx6poD0vXPuZkzaH8Bt6KoQUNH9vOYBzHndLzf9y6k8nLb0lxoob\\\\\\\\\\\\\\\/IMWGV1yY5wyDf0+LBCvjo1Ant9gqSqmaoNhYrj9BPrD77NXOp5q8iKfxUTpLvdbRa7KuJugiIRjfAotjb1r7E7aqbTohPKEcfLI0ZHMdmEChP0zQzlJxigu2Hy+QnYZa2GwAik8XAbA+HjbkRQjZex0xb9EmEbaxLwvN\\\\\\\\\\\\\\\/Noref1An661gI9b9dl1bwXE8ZisvWSkxX4vbMJGe4L63+FswhNfM\\\\\\\\\\\\\\\/hZ0Jajs60M\\\\\\\\\\\\\\\/msjFXCBqLO1mzwvY7eUlIVRya6j7Z69eulBFnh9s5JXjJ5o9n8indRjZrjyatx3hIs1GQO1PBlmNWPGt6EYD9hfWEf5snoLmvA\\\\\\\\\\\\\\\/kLuaP9BkRKHg5Cj\\\\\\\\\\\\\\\/d2uZljIXCSYSRbYaj5BwlMkUIpM68emjrztqhOIFF\\\\\\\\\\\\\\\/IcvdTPXdXpYx3JU98PvCDJU4DROtHsIDf8D9djvNWeSaiAPdARmNbg9TvSUGXJKdKOsH2xN+ToOEjFnEgNoySY4GzKGaoqtBjanz7EexQpV95TXSh\\\\\\\\\\\\\\\/dbOlsFptxkSj3vF2+OS\\\\\\\\\\\\\\\/8Q0gn6hVdBj4Y7Ccg898dkHVkYBgUhw+3Jic+Kf3KcQNfgLsFNtNPozIW0aWf7e0eMcfKslZHgvU3cCEXD3d9kSlCxfpQxcEeVuOrT3bs60nZ7oQPHJ92LhCx8up56aqDjwnpTWADIvcRlHMcdD6vYb+OA+cRIlC3QoVlFNwaMIUr1GgSNei7KQlsnSGsOYU8INQ3H3pDjov+1a+j4Po+CqnJSTZzUQcOiQf5F4bl8txdu390mginHbIenrT4OvblRGjMtyerB9qghSUb8fWO43VBpYvXU93xijySewDBemb8LK1CdBbFd8s8iJCtQovqMdPaeMvrAdKL0366PwMhoNIou4VQZeMFgNNgqkmg4a4HypMx6mINtvCXP4kKF\\\\\\\\\\\\\\\/2UaJpCsbTAqa1ZPCGMxS7F1vBvYq+IQWkLfXVHNsK7EcMqpJzl16SZboyj0okvDUbn4fBNKl1ckVEvM9\\\\\\\\\\\\\\\/9MjgNpK6tBdg8Flhm7X23W9k7JZWakdwa8JDZPtji+XySCY+S3VKS9kUEp9NLXylcwuKwfIzqJSA9xQC+AGNnjOQqh\\\\\\\\\\\\\\\/wBE1uhu5Ip9rdNPMvpz3Up+0WdkaP7kTY\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/UN7I2SDid31gPFVECb8tXbWJvKiQ5nHhoTnlaTu\\\\\\\\\\\\\\\/puUvbcrcahxic5gLwRmqWQnQXVo2THLhTBMJ1DxWN+5L8NXUmU7wwV6iWxKBDjBSC35zyop1\\\\\\\\\\\\\\\/aIwBYN1vmXl8W3vqbIXPuK6ihmOfoFtdJ6Q7FT\\\\\\\\\\\\\\\/PrfpXnVWE3gm5eIoZ9eWTX3aqowNhYBIxk+glTr+UCnmMI3m4UqDtrPpUrtHn2GlYYte04qTtmdKkR0Lc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022IF0UqQJa0vOiqN6uQhaHsw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002263c97eec5ddbecf962c8180dc0c46461e7303e30fbbedec827ea5d57f46926f1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e003744.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e003744.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003744\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003744\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003744\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}