{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022DDFV+gUF\\\\\\\\\\\\\\\/cZ\\\\\\\\\\\\\\\/vJTKDon8wXVJsb5jJKKak39MO78qwdzCxTRY3fWiKJjCnFQZ3Rlf5HU1PVMij7jEMU7ESijL1co51r4cBqkXkXiqpU84jPLxv4df\\\\\\\\\\\\\\\/aeXS\\\\\\\\\\\\\\\/2JbeJcFX9M7eg\\\\\\\\\\\\\\\/BwL1RbPFsnAdeqD+uBPu6NbEtarHYmq\\\\\\\\\\\\\\\/SiA7TCA+BZZpj\\\\\\\\\\\\\\\/h5EZt2vi69oIA43PQza1Vk70cKatfE59NbTCeyq6idY5dP0PtUC3ee05mTbxMr7\\\\\\\\\\\\\\\/T4BCMIwtAS5EVRZtzjoJvOpeOF8DKD5LedSiDaAV8lEgeIIhuHKImJYJnPs9gaBdCwuMr7UXxeL8urpaJzrTVm\\\\\\\\\\\\\\\/KMcvAQw4t0VdJ7zu2ZYWwhvaLDU7S8qk72pODijl2jvJZQGkjr4RSQ6Esytdr\\\\\\\\\\\\\\\/7M3veQZh8kFB2QNX2px8vSZ+ODC\\\\\\\\\\\\\\\/CeVgG+QT\\\\\\\\\\\\\\\/k85\\\\\\\\\\\\\\\/zuIbSV12RmuWpt02MwwYIrQH5GA5aFm06sERgTsRj45CGJlR5MpaJPCGqX5dczWlxLfaTXGoj89B4\\\\\\\\\\\\\\\/hyBeLJNoiXd\\\\\\\\\\\\\\\/dYV9BPYoEMxHTobLsUP\\\\\\\\\\\\\\\/LRCsg5aKW0s\\\\\\\\\\\\\\\/Vb9Am5u0mYGKmWjzAlI0ggL3jN9Gk9CH0Uae8I68WhZFiiObOGr3voTfH1lMd2ZcaWMXBj4upZH3Y6vytG3z9Y12wFkmBX+pC\\\\\\\\\\\\\\\/+397+RdzwvjaFidxB\\\\\\\\\\\\\\\/eu0Z1K6eIxLoX8qLoT\\\\\\\\\\\\\\\/y07jTZ88s28YdFOFm69HDjeoQKmRY2e6HahJWqdoq12UeJLT3Epq7BplSkciSuLrPYJXEidKb265ENfQDP7aLYmG+QB5RrWHkCwIWjO4ylsypUJM7m8ebgN5FoeTKzMlVCVa4Q6Ein83msNO0yYxOICVkXIhoXZZb73bLvFLT9jpS7eL\\\\\\\\\\\\\\\/yrGX9Qi2Kto8g1fo6e6v3wV7LvzrYd5rP7IdihACauw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/PS3O7t5NrEkOu8bTXfLVYtE3yoQYk8fI5Dh\\\\\\\\\\\\\\\/AWYtQ9xhCQ7jnfy2jYxeU\\\\\\\\\\\\\\\/S9ZAoKoMv9npFjE3FkgvMpPEPX1sq5aalVlCE6MJVnWnLHHY7SLWT43dRBl+XhdqsVsfmHN1bFXK+P+LzJDlWA\\\\\\\\\\\\\\\/TuM+HxCs+14vp\\\\\\\\\\\\\\\/4T6sDAyt2IxjAY8aEjCVcpj6TNF8SR3tiIMupDcyvaBthncZAtchMGaudW5e6An09QXys6AFSEWCfmou\\\\\\\\\\\\\\\/YTMQI8UpA3P8FKemYhXtoshBUQ2wOrKTQrxvkjKjT7MU\\\\\\\\\\\\\\\/EYehCMulUjz3RLfajKqfK3IuOjY39qqIQJpuBeTkUzyuSYIyJa7aIKcVW\\\\\\\\\\\\\\\/n9XOt9VKwfpWsWZ3jxqnZtAVxQzgEwg+xxVfdSRTrO8GosifI81jTmOCXuYm3To7qWo\\\\\\\\\\\\\\\/y2IZpx6Zr\\\\\\\\\\\\\\\/2NY47n22tiqHSCxuH\\\\\\\\\\\\\\\/0NSkxDqMJTW7snRBFqWFyOs7VabSkLzbi9rPgZ9qp1Hr0vb8bYCitzm6nD9dvutL8UkCkRB9P2\\\\\\\\\\\\\\\/hgY6Vfg58gEDqzZiMaxeHz6GAE5dcmKWv5a1wWO\\\\\\\\\\\\\\\/uex2e9yTViSG1r1t61VOutVe9bEc34vkYEDEuWt2D9PFtW5G6HGoR6+OrqjT0hbxxTRZiq\\\\\\\\\\\\\\\/fVUS0m9ug9WbnUYgOs5ssQWF3dLPf73LAb0BHYKijItCTtSMwbVVisjUrBLoubGJ9zrMwCMm5vNWNm4qZpPE2JHAgMEDyr\\\\\\\\\\\\\\\/+6kPnvpslGqYrOuw5gs9NE\\\\\\\\\\\\\\\/O9nAmKBQAlmM\\\\\\\\\\\\\\\/GBd+1e22uzRqgzO3KpxPERHV7hKmq+vs4\\\\\\\\\\\\\\\/C\\\\\\\\\\\\\\\/FfBvP6iFOvj30NJPDXcku73vS61KXYj9MBdq3eFzVK18QWVZcnrVGauB34Vl6OMq\\\\\\\\\\\\\\\/au84g2cweqJmxWiPfmjltAiOUWVz1PdfQcMPI2bJG+zLjWpcTq6+MJoWCrHKaLxgDUK7DM6qAz9qQz4A1qMGNEtYpcRdvC9h2aExH4dT+gdNNVIa4o6PTHV8JFZqQtjzMsBV6tA\\\\\\\\\\\\\\\/2z0tj\\\\\\\\\\\\\\\/lNkVhQqIj5o+bhjrninzB2xsDM\\\\\\\\\\\\\\\/d+eGwiEGVFPFjtAmLChUUV6KBIggPjbwMo3vElCiCWFeilEvPIfSu3S4bVfT0H0CfVelqUbuC83kEFm4GafkhdfnQ1DCzJXRVjUwgTmAULOMx1x1v2gfxH0RELm44UCtbUVzrVTJ1xbJVwUyEE1vLbLiZ+7Mf2\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/R3UBhA+fdsnYaLuj5R8iJdR25hCc46C7tkb98RsLzyfanzDfWuvfXO6Uyor2f1Dv9NWi\\\\\\\\\\\\\\\/6iPXz0OLriGUvGSsdwax4twf4HKBi0c\\\\\\\\\\\\\\\/EbUh1\\\\\\\\\\\\\\\/D+bt\\\\\\\\\\\\\\\/ZSthn7aHcTip4WbcXMiP9DIntOeZfg\\\\\\\\\\\\\\\/+iKpEssFAswrv+Sk8AgD28l0rpLAtAC3ooOO+vKMc8U4pOG8T8nCAON3a6fZEQQ1BM86OLMC2Vqp6xUKPnPKLidCc7PfrDAR6joB+AgByygQkfIZGeCqA1JGin1eJTYYu3t6A6itEN2H+N4NSlKBA0PlG4lBdeS+I1QUTxxM+fAbJG8h1Ns9bq2CsLtwYl1JMnuDdi7zeyC6Etr9fCqJnE0iCqjHkkYnB2hvMX2bG\\\\\\\\\\\\\\\/HPWy1fOri94Pbp9UjOuW3xKVd5IaYX6tpKwkpkMblrWsz\\\\\\\\\\\\\\\/wafHuVHHoZ\\\\\\\\\\\\\\\/QufEPObTzm85bxFQOIXaXc0Rig8Ob0MPi54Q05zj3GiDdhFknnUv5WrBojVY5fv8E55vZw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022H9kOBxJpqvfQZ+Mbf8uTYA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fe87100053e948ebf5f23156c2e2db5dfba74e5c5e05468fa4736bd45b096b43\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004799.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004799.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004799\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004799\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004799\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}