{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022NN6ZgGXS2YJ4BnIK8U4ciDm6EUtK3vhpkE7XknZJOT+MsLPJRNb7IFer5F+rGD5Sa0JvOKrZM3OWPwsQnRfSd4uTogzdB1+KnoA097SLCSEDQUBW4hxkr0D6H9BKhjdf4B8CdSpfDrgaky6ZOwIVaqvX2FlUH3Kkezchss\\\\\\\\\\\\\\\/qWQ06Z9EK6mZOmcjIL4ztJemHY8gyvp2OL715TFZnOg3SoJVtpWIuQToHhIdFSqFhSoKQH0btEIk6Ltlw8RG4r4doe5RH6I4uJQEHbCPkfV62DksRHleSCFPFmvR16NFlJ+DSonedzkLmqS4SknfclHqGhGe9pj\\\\\\\\\\\\\\\/IRa\\\\\\\\\\\\\\\/WHEo\\\\\\\\\\\\\\\/s7s5mG9ahP2aHDQsYfe8seDSLZHIxqF\\\\\\\\\\\\\\\/P20ZzZYspW0oWHnTPSFR3Fq+1\\\\\\\\\\\\\\\/iI5HBboDGwVmmPHz0GHj738Be\\\\\\\\\\\\\\\/GeSQHj54MpCrRLqA2zdfWlYX5YK\\\\\\\\\\\\\\\/W4cyvkTIHvGJezZYK6w74M65iRpmAzi6797FwQEWYz8hVThjMAx7T0aDRXq89gekbQFbErIsbt7dC8jVUGYQtaK0ij2Wht6aVZbg70+YMhvE0mY3xpywn8I2q4G0k4Q25uEAXK3rw7bc9LR1A2QLiwbC\\\\\\\\\\\\\\\/goa1q3hqpEj0S+\\\\\\\\\\\\\\\/6Wmik7g8E0Jvmz+r2MAQTj5H7MAUreBxk5b+\\\\\\\\\\\\\\\/FDE4F6WOGx66G04qXK\\\\\\\\\\\\\\\/S+6d2+fvbi+AML+K\\\\\\\\\\\\\\\/XjgRSW7u9tlaapR6HSjGcJfG688xuRtCD2qPVFxpOzEbZrrc\\\\\\\\\\\\\\\/P3TrQ7zhq4TTImcITtl1Nl7Gtkguyc5vPSTz9bQ1IZ0LNn+D6WyemuonwkY9AAr96O+c7rL54tDSt9BDnXkQ+Rf04RZnX4Bvzo9Nu688MUvsAmruJ2sQUY6G4K4MhnzUNsob+Mt85Y2cGGQ\\\\\\\\\\\\\\\/ojT1XuBCBLcnnQjALmQZmXUnqOXEJIcLIBPI1+wmjzYr5VubGmD+lqlx9c6NPuFFzyeV9powwN33yqXywUlmxjhnl1NuDe1MAU+X4ZESp0Cmews8rGnEddI2W+yPt1v62bQ0VDiIjj70i9RUX0NTd7Ry+UGNnbBqfl4jvTLhEKKH0sqPyar9SRfWUKsF6g\\\\\\\\\\\\\\\/lVgqipQHxI9sFlnuA\\\\\\\\\\\\\\\/BHNlt2jU4coLbrLJL+qxvg+QsY4azWP1tK17oMEh4GMQ38oeliBbnLd72\\\\\\\\\\\\\\\/N0T1yN\\\\\\\\\\\\\\\/BsUO\\\\\\\\\\\\\\\/sOMV9KqusBISGLbqMWHEyjO+agEvRTl2aVoAq3Exfcy+MWHEwK5PkCGPWW+zdOriTZCBBu9PL2U10qeIog6IK9fg+ULZEBSxDkXHSYFWh1n0Jti0xvtCTdmfWbQyU5muB\\\\\\\\\\\\\\\/CTEKMbtRbIlWXUD7pAfDahqpJv5PgVYtKX+yYqfYSwV+zeJ4TDXFYMnxZbJGHXJRWpy2vtvB0p9JXRo3WMYJpdxQrYqit7JccRFNxNRHuyq3dVby2BCMzsfATtxXrEOh6hiNj2Tzd1mmDuoRjwf6a\\\\\\\\\\\\\\\/vGRqJrFWCfDQ8lZGztlJkB8Rujx8wt7Sm0r4uN94YyUlvO2IIwMa3b9DH9OCtz7djAa8ksgdL1+s1qwXfkxvdsqRa84INQe3KY8WPdbQHjykRwo9MDVqBNxFLjHEBYlH0G9MgZLtC6Sbf62OLXV5khq9E3n2EXao3dwitDjgPzuR0ljGiw5iCFEExXsNcAVKFzDl1qdD9OqiRmx93UIBi+m8hfHz+LhckMktMhTzSE89pfO3Xj0hkOKoIV7yIGYMzFFCgI+NRVJylX3NJle2x0zn5dgKkOWEKCgn45JEqUINT8UnkwAtyfbUbimllcL0J1Y8NPEAruG98Y1aqBiEtPWsVzENR8NJvACaV0JrqS6ZPCc1EGRbunBTueZyMTqTGi7aHN84MzrNZ+zClXUOF\\\\\\\\\\\\\\\/rKlCSrt06+yJqfg1OlgtlkSUJaApvDGr+57nnUJeymKVyUGxhkIoLemdCxfKZTsHlqbe2LQoOkmEJhuKj9GjhZ+M8q1UcG7KkXp8NbG9wvm159b4vUNDTTHBEAUQrW+5UDFOydLmcauTXZ3UYprrurwxRnVI58XuV1boliDDJrn0C8v+OEPgn4IhRWZQBJPx\\\\\\\\\\\\\\\/sJU7OhltB45xsX+irCXfm04BmTWQcEJG2cFS08GvlVrRvL2bEjXQwKzB+4b7VKzawcZiNNFZlsmaYPGBkJXHSxB0MG2\\\\\\\\\\\\\\\/pi4Gms+B3LMOroJnqQx5\\\\\\\\\\\\\\\/NrT0KoMi05EZnY+kqp4SEigmHJ14yeoVsbjopptvaQcfXhKz1PlKTqfGCATg6pa0MaJOVWkkQJNYZjxyXKANmPL0bQ8Hf99yHBCW\\\\\\\\\\\\\\\/EI4hVhy\\\\\\\\\\\\\\\/4A4eVwOww5CLwmQwIkM6naYakGAKFYscxJ84\\\\\\\\\\\\\\\/z65OgMszucInc5aXbXUYd74umodeoz5UTryf3VlsUfLQ5BaYT+ZJwuzP769XV7dZI6v60LhwUTbKLLPh9Bj4NF9KPAkzSsKpVMpNd4F5203hPnU7xOw21gAzkhD\\\\\\\\\\\\\\\/mQE+j\\\\\\\\\\\\\\\/H8vhFDb78tVqSc\\\\\\\\\\\\\\\/uE+v2xIYnqCjP2CTMauvPeSubd6UE\\\\\\\\\\\\\\\/jsdSl\\\\\\\\\\\\\\\/kdrObBwwvg5zH1e0TFewv5Fes1Mh1Mbh1aaHNVnM+B3VH8BCwGzRWoLUiwFMZ9OWfqjQUkYDBnERe1rsrVakIbT4J4nTjAuwowETNR6dmkOSPKZNxjQ29OvS0Tg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022uJyeYFlgtg4oFFAs2VG3eQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222bb4a0b6713e2095fbd4d442a1103f2280b32eba41d90bc3c7f760868c2a181d\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004312.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004312.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004312\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004312\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004312\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}