{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nUd0E4MoeJBCvnDZHDOlLAA2xhWabSb4bq7\\\\\\\\\\\\\\\/NJts6\\\\\\\\\\\\\\\/TY7DICXgvldDpKHTCDhUxQW08Tke++opEpsQr8hH2lsVOqf2jk0a6t0yUz1OS5UGdHsCn0a8JCJ\\\\\\\\\\\\\\\/xq1mFKwCgSDMXrpnCBdoye3pnnX45Fab5PSL3m\\\\\\\\\\\\\\\/Sl5n4YKWXAlzyf23ZEQYzmemSkZkSN6JSh54EuA4vuKXC6eVMZpsS427b3GzOr7EYUdeWXay7WmRs3SC27HoroYYo2xAeftMKTh8ZQn5re3P5ABbmq90iwwKbLIsrlwGJNO89tvWvQyhNV3Hupo6MJfP5VoqDCY7ICeKtaueYRn\\\\\\\\\\\\\\\/o3TyQD\\\\\\\\\\\\\\\/7NjKdqbBpfgx0tqFBHZjw1Tpg76RTU0\\\\\\\\\\\\\\\/kgAHBkU38G\\\\\\\\\\\\\\\/r1kvJbXSYKhLyrvPyrjeqlxxq5jZDP704DtgdTQ3l6HzXduhZ8bI5O42JETjfMxk5AAii3QfRamy+vuRqn8\\\\\\\\\\\\\\\/oWn91uIR2Z6rmOuTLWJmPHysXqlhz4R0pp4zIrI+UxXJK+Odhe8JLoQd6MKX\\\\\\\\\\\\\\\/fbcbrX+wEtiFVte\\\\\\\\\\\\\\\/+eCa0C9R0sG4G10P4ZIYrlpqRTahdawAxKV2j8dQ6bbeGn9znDCT5pMkMRojpNYFLg\\\\\\\\\\\\\\\/dBgy\\\\\\\\\\\\\\\/ET4JTTyIbZv9mH04pPPjNBRwIugiELDiflIgK8mWTy2E7ye0U\\\\\\\\\\\\\\\/7qrfZruCmwEaHcR\\\\\\\\\\\\\\\/Lyif1FQ7m+p3FAIfgPBhW7d51N9AIVHrlXXQE+I8B\\\\\\\\\\\\\\\/Vfgmmu7xVQ9CVGhqdbqaFcC7XogtHbL6M35DBSPNVz3wzoMQyQudoIyzQ8ox25b5Q5pmzBySta42u0MmdcJVndBf0+S48trOQOG8hmjhcoee3FBUHpoleK\\\\\\\\\\\\\\\/VQXUMLhyTkMJLHHP54+FM4HIDReVqFd+jXZRbPV\\\\\\\\\\\\\\\/Zgc\\\\\\\\\\\\\\\/4wHCJLvIaWg2EuFLyBS8Hvm2v4F45ydvQX40Yx9YM85trGQKK1OWYuLt4OEIUIr43j8q9tbMCfdTsBfN\\\\\\\\\\\\\\\/5pw4TT4Z8zOG2k5nm5XIEDetKyaJtkeK6CaiB5hkDrNdQ\\\\\\\\\\\\\\\/3LVi95CT9omGRiLWIarGtwiXpJ5dmZ8WsloJ+F1VVybAQyPeEQX5wolmLh78xo+CAV\\\\\\\\\\\\\\\/uh2i1QU129qvfBtb6Mx+VEJv64Z5vhYEJxDUIBth9sWBPB0b1U2i2weY8GPem65xkxAoQBLyewlOPitmIdu\\\\\\\\\\\\\\\/XJsqvEcUKL8FvpxJHGPVac10OiVpG4+vBrwmwbITfZ2+Ske+Izxpq8rdxu\\\\\\\\\\\\\\\/ft4qNhMDmrgAIwiGcLn4T33ShzXRQ1xFAtGkre6oPcGpDlAADo44Z\\\\\\\\\\\\\\\/D5+SspvZb5ghS0Z0uhnKXbnrx9Q265jnJiLWHgRaybUbhH+uhVthiSIWBW4oSRJP9jU3pUXpawqNaNiD1VbLksXLDBA+In5upf7B9SSz1c22LjPmcaITamKSBcQvQpV+qRhm9tGTYQK+wt9r6hR4j8J6O4SDqx6JWNe+ZolSTjVdiSebiXKMJBgwgWDrOJzhmemCzCGidvoMCYjvCkcusoCAFrZxW\\\\\\\\\\\\\\\/jNHByOYyGZWBy2OsTOwLtziPYvtC1z5gmud5AsMnQTTodBkgrsLMJhCNdOLyx4hj4MedQzzMHefE4Z+cO2AXSUoG78zWzWzCSp+udn8TdA4JPIEglgAvPInk6dvcZPwEhCfiI3R2\\\\\\\\\\\\\\\/jmWPceM6SSPh17rcKK6J5t4b9smNhcB5lXgbkYo1kUlmMGYYPmVQEjrOMDm2C6eytzhreOkkU+IgQbbPPyI06la7NjrKrN6X2gtmUfKJCC+WWhVuE7qLn1PXhe8LhQMYqgm++Hzgl7YFbkLRVc2ZQY2C+4wqCsJWANfcVKrUcR3\\\\\\\\\\\\\\\/rVdIrH52Lz1QFZzA5LTeYb1ePiW15WBeNhMd5cKQkLjGgQ3FisMnPc9Hj9gSEJTEJDp0tRIcbnQFNE+fCvhuoSKZ0iQ2A7s2Of7dy4ubC2wwlxxObrsanb\\\\\\\\\\\\\\\/Vq+Gq578k7\\\\\\\\\\\\\\\/uuKtRCQI5b0ErdAO\\\\\\\\\\\\\\\/CdV55Ne8v21FOMyNkDZuSdAey\\\\\\\\\\\\\\\/xT7zYjr6gETDEGfOHJ1kVJ0lETcExEzUpVg7xRkWcHQAMpyDJb0x7RbKnwVtAK5N6MHaX+d55yGwXFIB9mrgl+N2iHZMeA4um4wQk0Tx1dSt8gZYAfJlXLCdL\\\\\\\\\\\\\\\/0ZxRhevle5R9BbOGsWRJBPg\\\\\\\\\\\\\\\/sjYExaafssg+kNPOlOfDQL5bcmqDs9+feTqgojuruBoPQwk3jngIT7mn+dKOunHvvIiznn2XGM9UYkJcxIJUlM9sxqkoOtDv+XwYfFjb1vfOGm1MaBv7bN1IQSJeCBHFz+pq9UFFBaeIfw5VaNUfaI5co62kT1QLeZF\\\\\\\\\\\\\\\/fxaH+sroPvRZw\\\\\\\\\\\\\\\/YOlaMjWuZeuXPGEohfEe8Q4ku1dCFezoaUj68QeI1hDSlEGNJ\\\\\\\\\\\\\\\/gHzvrOoGgCT3m6F1oF9AR\\\\\\\\\\\\\\\/VlUSzftyDXasdUzWX90quYUIAduXvVcwCuZFg+JshRLN4tJ6LpIDUUl4lWJ5MQQLCLfkNbxjYGa0Ug0RCPQUTZ\\\\\\\\\\\\\\\/OEACDBTWxcWX0vvlqd1EzZCDwNUz+kSHlm\\\\\\\\\\\\\\\/Zq6WQLjx4UVar01hynGOaf2d1Ib4w3eFNvvyvdytpYaSJ2HAd6+P2GyVNtC9pccuNdG4s3bAYeRpJs13LS6JF65c5pYIihOqa8ngp5Pyf6w=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Wr09+3z7HVufmMuXdJCIbQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224b574e712c253535ee5d91813033bd2b7bf580fce73cca6de752cb9ebf654629\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e003957.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e003957.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003957\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003957\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003957\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}