{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PGDd07toXn9yJbuB+9V00PWlLBi\\\\\\\\\\\\\\\/eyInlmEBaJcq9qVX7ATQT7++wrBQAvBJvRO6qDVYDe2r3EAcax1Wi2zTV4tr\\\\\\\\\\\\\\\/dfKoPWEFoQRs1oNOEnJI+PMZwZuMTsCVc24nbcBkzq9SRFwPrvSplM4Hu6\\\\\\\\\\\\\\\/lQbQ5wYIpcuDFl5eczhHt7MyKAjZ+NOOIyUixRQLtGnHenkDJxErbBSUsTL72qERJwgS1i4FAZOWbRD3KOuOxUNQwboYd+O0kK1lgp7iazlUPwL9KNSMbLFlZN8GIWtDo93VnYt9diEKOKn4pf\\\\\\\\\\\\\\\/bD9Dy0fBKzBreqWm888MAeL3G8bLO3lTfnfeb8ZmtjeBGhTFfvGfSY67pKtS8a1K97l9ERye8WQdvFni4Qx7B4ZuxsFIRmyUU8As4T1d3S1gMUC4xG43babwUl8ioIP\\\\\\\\\\\\\\\/np9yy32uTTUX4qcNkjAY5TtvckiXjN+n+Jr+pL60xi0AScvr2THxnNrhjRQ\\\\\\\\\\\\\\\/Ssv6zPCcSYNNn1k37XWM0a0xFtMCRJxJbcXTfJC2rQl\\\\\\\\\\\\\\\/Wela\\\\\\\\\\\\\\\/kfVW1Wrz+UMjNhOeelgbwZFVWTcqjyhzGib4qNhvMYzTHlxkuP91\\\\\\\\\\\\\\\/3X0fLmxqdW2dPFaZCfvviVm8Fc+kafy39YFy04EqR4FB9rsngbGjdoM1VsL89BKrDbtf0V1faA6yHt8F0o9FS\\\\\\\\\\\\\\\/UkkX9BJzuNxPcNdsHnnKQ96AJwCSJ+a6JfSj\\\\\\\\\\\\\\\/XrjGQWX6PQzKsY6sjxkEoBQ5MyutI4tQz6hDFR\\\\\\\\\\\\\\\/k39lrr35ioSV+wJKpCzmtpGmpYLb++HPKvHmVwY80A5UxNVpTosGoCu+2YJSae+B3xfmvgb4LwS6H7Po9prO05gosnSoAhCH3fk+epRTI+FQKfQ1k4W6a950OmwLpwE4fO9dYOu6vMhT23Yk0zGJ0iwJpXkor0ZGvypgkAzeL1buy0jG15LwCXYKW0sg9WWqKRIDRuVpIygreiZ2UQ8\\\\\\\\\\\\\\\/+o0jMnCjF3nV4t63wJc4NOXIGE7IsTGRGx3AavZlJ8vO6pZ4Y58OzszTHy9qefwZV\\\\\\\\\\\\\\\/qNA5qsgphvM0AxDZmtUJQUOaq3RJ2zraBubXScDTBATMu1PFm2YKaIGSe3jzgzu1iHBMvygi5kKsMuBwW5\\\\\\\\\\\\\\\/Vi3k5MDvE10p0pEav9cTtmtg6Um7d6K0j\\\\\\\\\\\\\\\/LXIzZSij3BZT\\\\\\\\\\\\\\\/jSpwcXrgVhTXP67THT+Ffhkzh7QDEV1kxPk8P\\\\\\\\\\\\\\\/Q0ytEoE6F+f2bncY2a7jfukm+qspG9+iZjoztyr2x79cDS1Cr97O\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Iux2I8TLzFRnjJLiXfWGX70WTt\\\\\\\\\\\\\\\/LiXLBDGzgPxNvQ+RmWzwOCAZUo56k488VCJi3gOxvh3FpQLdVqBjpeagBN4PUJTOZZNHJemyKbRwXOhi2BagWcSga5oBUNGwjOGf+mGNwwHBzTHg+pQnKhUzuN3Mx6yF9y6l1QH4ZXwCf93ZBsXDf36fSSPS79J1Jf6lwnRrkGKxlg40BEihnndSVjslZC+2L2Ar6N0q\\\\\\\\\\\\\\\/2AbytCuMEN43x1acnBh1FGwPCcHb7R1ciqkT3qZDGpLUGVSnMRZrH\\\\\\\\\\\\\\\/jxIqgPcAwk0iKGXscX+LjFH7MmrAtAm3OdaadB79Cc5tPSDrp3ZnU0i4rryx579niguyeHntZSRBFvEHnKhICaFmgdoEe1O8Ah6Mp4TSq\\\\\\\\\\\\\\\/3ZKtlU2hjDxqb7aH\\\\\\\\\\\\\\\/0mQHSv\\\\\\\\\\\\\\\/CibG5Lcst2\\\\\\\\\\\\\\\/tNgxss+l2B5j7KXxPQzGaw95oAw6ZbcZR8cR9ifkHNtPzuWnPZ9bqHPl5kFTEEgRQ3sLm\\\\\\\\\\\\\\\/q+Tj5v8DbMQ7ibUkbTWRZmjTn\\\\\\\\\\\\\\\/PuLeRLMKOboW+l5GkYb+FZXeb1TBA\\\\\\\\\\\\\\\/Uwpptim04JoixEyTexue51wz3tzF5P2h1kG65mCBw0YNROFFx9gjvj6G415zlPa0rH+grwP4Btckma6QlGYWA8jimPOhAZkBOKGIyw3skONdphsP933rBhz5CqfjmRwmgCNG60OHETGl946RQHsdjM7PY0sz\\\\\\\\\\\\\\\/ReI9Iy4L+gMIxxK+sQLMuQw1QJ0Ifvj9zTUSsPl8Ymjvfl8wHIy9Zc1J3k3F82V+0zKy+1UXIRzsWUwQvXzLmMq2M9ugIgAkcIXfd1QsXXNRqfURNuwT1lMjdy3V\\\\\\\\\\\\\\\/sLQhz4wyp0+DAxzoQTprdWc5YIRRbjRhTushbuGwHAjS+bOUfmfW5Em23YoXNbakcsjTM1sR4BCYcw3sX89PnhnPhSDQqekNSLi2sCdNuXg6BmBpI+b5CAhtbPHWH3vgwAaMqJhOaPoMbrZSZs1F3xY+Xx\\\\\\\\\\\\\\\/TrBJlixo6hfYz\\\\\\\\\\\\\\\/weHnq+5B3uCykvRUUM\\\\\\\\\\\\\\\/++k2TvOgNCPleWbG1cWuorhuwULLR44wE6OshYCF7fVVDZ0W8xnQIpXkBbxfeUU5CLr4Kidy9nq9iKodYbvoK80Mie1PT50xdtxZeKH3idVtOB8ztZ0GDiB3Rzhv5SUHDH5B5To82K0ivXTq5ux5aG3x99d3\\\\\\\\\\\\\\\/8TM20FRyhQd5mI78trFI3vrrGth5bCpTj6efLgdZsSP+XbG3YJT6LSOAkn5+xz70FVZRHriWZCpkEaeBDGaKriDU3XtWhoij4V6Tzq462Y4NIArHiPuQDjPheROEM\\\\\\\\\\\\\\\/o3N5dTJyfc9Ot4+B8doSuvue8W1L+v7tnHc4OHVnYhm7gbUOdo2ohI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022P67M4agl8mB0ptZK0Yv0fQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f1e1c50821cf48b1074aec531105aeb05c5aeec8119dda0b04b2aa201139a154\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e0701-2corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e0701-2corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/6\\\/e0701-2corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/s40425-019-0701-2corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/s40425-019-0701-2corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/s40425-019-0701-2corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}