{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022WXWpzGaF5xjXnpLKxkaZpw8MvMDDhgK0x\\\\\\\\\\\\\\\/DozkVSjz9V0c1Kww7s1olU1U9ZVY6ew1q\\\\\\\\\\\\\\\/nsjf\\\\\\\\\\\\\\\/cfKmHUL+S4oX8ilwRgELKTdUN6cxuqRnFs2cElfNE51jW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/F6BrytT6b2mFiIc1Ridcqmh5bOczhLIb\\\\\\\\\\\\\\\/XpbTDmXU+SbidLwFK4fW79ZdXgCGkNTKbizUy7aQTW5PIqte\\\\\\\\\\\\\\\/7noqhHmEtQXnsr9PMXf3MdbFHViGlOWihyYcW5D6ekjsV6RWUrWld4JlR8yu3HkNqIBWH4kfXxakjgaiN9Z\\\\\\\\\\\\\\\/qsbDxm2MtKTXGp7uUUNWwB4XoVX4fMTMwSWOu9zc4t30Uso7YyyE1zcj3UNesKEQEKA+Hv06ntSOtHN9YaeH+lbVjBkIU5jQNzqL6cTO05OPqg1DWwwtkQRX11YnJyYa96ktL9Z+NbLkh107J8y5JiZ4vRShf8Ni1gkCBjWl1P7ixp2tWRPusJom4ex9Zq8LbHhJsVW+rExivFR\\\\\\\\\\\\\\\/0dSOr2JgEv7CAwZ9U9Qof2rWQKA\\\\\\\\\\\\\\\/M7vYmtvqFP64QKZr82Gj19e3qn3s72Xu8+AmqXxhzWMhCnTn2aXC9Daw2onwZgKbLjSUkPcbHQ\\\\\\\\\\\\\\\/vOvnbSjPAOFFuyTUjBWl+p94Sea8kauIrgR3kdgWFI8s37+ZIRZWWvsnRrOse0cws6Xlc81179pTMTtOTzrDyYfFJVTzNEOr1aEcBZycKvGq6PEHuxwsbqY0yJc87IJevE8lL2yRWA7psj5+U3z4gTh1VPck4uwD9r5o\\\\\\\\\\\\\\\/EZ8+TYQc1PB8SDorHYx+c6sLpuWwt2Uv58guAIEmbnWQtXaM2rwaDqC7jRDMrZ\\\\\\\\\\\\\\\/C5jJHDqmB+SG4Dxw+X9xyl\\\\\\\\\\\\\\\/YQW4Ezx2OB1uc\\\\\\\\\\\\\\\/LO3RMRxe3kZ3oO5H147I4O6i8U+UK\\\\\\\\\\\\\\\/UdsjABArbkgiRUxIdJpcx1B\\\\\\\\\\\\\\\/C5HbvIeQZiAyX0xpxQ8nIvBlQBXD5K65jo3UEsl16u9vlX4naw5v3n0XlO+U6xG5AarI0glC+t3ypr5m7bc5cw8rGTEz55fUoLkx4J8X5KvK2Y4lThyJtIiH7NEV44brlcV6RZOGdmoZxqYmJfL\\\\\\\\\\\\\\\/MEx1VwNy9UuH84Ef4gpYCPERmEJ5gHdYcG4cf6PDDDA\\\\\\\\\\\\\\\/9rw7c4CRUwoNueWpno+Xgolw0Ru6W4x4rei0ZriH4CJBhCTy4k89y\\\\\\\\\\\\\\\/Tt2yXKDWjqHNjZMDo5R6b4vzcrcfZ916pUFEQE41EAcj3\\\\\\\\\\\\\\\/XkF89b1aSXQnl0Sp91HN\\\\\\\\\\\\\\\/9YpjnXTWc71sIc32QvKzRtEJcBcTPy5nrLnTbAi6sSF8zZW2ZOkZUYBtTCcUKId4BhlYdScI3g9S7ZbMFv6efhg4fRSrG4Yih4BkrYJTXX\\\\\\\\\\\\\\\/YyqizyMPdVPLrNDBn68ZC8b6Llljx4nLTgk8GQcsoLAjj80302+EC596dzDpMh3cfCkqghwY4TwjLe+XVIvrzqD\\\\\\\\\\\\\\\/ElLzlYsXgujexPzjeTn40sd2\\\\\\\\\\\\\\\/GlfjV2IujUXIPVzpATPtZAgBqt\\\\\\\\\\\\\\\/GIeRACyAucrrjKZJDOhK7vVR1rXPg37\\\\\\\\\\\\\\\/QheryJR5acsTR3I9K0EaqjaHjfYmNop9GLvktX9n2GWKtyualhjS2jHsVWS7fi\\\\\\\\\\\\\\\/PjeuYOqW1QKUN5iWX2t4sIQktWJkDIPNc\\\\\\\\\\\\\\\/ZNHmIyhCXlUsaGesiB\\\\\\\\\\\\\\\/VrcDvcD+5M+fwIbzmUKHzin0MmAI1+MzQ0fbPymPTJUAs00XqVtvj+oVF+D3qVrpCQs4vhbPkLLIXzIBGskzRHLIwIMqoyfGi+nPDwm9RnX0w9lGF6ojh1l06MlkzaEi\\\\\\\\\\\\\\\/kvuTCJPK2E+nE5lterUMmFfZXVNDYPGGl1aNh7ksDS1fxKsIhFwBuJ7v8108EEyN1SZLc+DS6GTddTmze3cPMJdDGLJQaZJfbMxgm3vwDSDfv6uJgAvwHQtEiFUKBrivhzgIX0l7d+YzQ\\\\\\\\\\\\\\\/Z4v97sL7lYVLxqQOFNLMS6NcL0HuOv9YOXu23EuIf8t9FTlBr8P9NC4En4iKwKv88KCP2lvul6\\\\\\\\\\\\\\\/vGfTRKs\\\\\\\\\\\\\\\/I+dciVGUjdlveZheZEYP2E8K0E4aRWV9WLXUu9Q9gikPxZaHQcLvjDUXf157aiPh8r7OjbYz5dfAhEvzzv+hLMK+SmcpMWwlmbOJ6GwauQueqtGtJmv5Z+WHKYWkRkcxFYC\\\\\\\\\\\\\\\/W2CsZE5al+jURzklYAXkBsqU15AsqV9T68s5HOBmTyMoGoWMI1vCk6JqEbGWFSZUmFbAy5ioPUJgLoZ6a196V3FzuQtWmNsrGumiEccMchFlMN66jQpySMNcVpPJS0XCtwp0fSL4p\\\\\\\\\\\\\\\/WU2CyFjiCNX+Qm8iD8fs0DqSYEUJz6Y8jhWsVXEzoSZw9\\\\\\\\\\\\\\\/19d6VqCMlcYr+SLy37aWxWLlzKu+uZqyj3wXogExLDEyIhK5XtSDhGczA6WJf9tFdHawsgLgRL\\\\\\\\\\\\\\\/gYDlSYF6ZSmjmlix9inhYp+lYI28Kn+I5I4X53R6jtBbEvfGhnrS\\\\\\\\\\\\\\\/SDK\\\\\\\\\\\\\\\/PIzbibGZdMfmEjJz9QYKoshZrqiXEr7RGSmPfK22+03wjDCWGWJ4lLjZjA3oHh3So9kNTPJS43mwzkdeEw6QTJvAbw2BVJP2P\\\\\\\\\\\\\\\/qaZg3qgUlCm9VOC5QR0ZxJy3xa5yQxepQdawGWeQpDKcCcLQgPxtBlB9SsyK599Oml7UF96lVhntZE0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022iL6jqHHkAtDvFM0ZzPwHng==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ec60cf06ed081fce2d6bdc94b0295a8f2521d1bfd04245019b9739547cd635de\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004762.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004762.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004762\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004762\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004762\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}