{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sHTYkLB2K+QzbhG8NxFiKkwyK8WSyhSmaYB+xrSdgCWoVxWSdVpG5z2Fa6VXubtH7G6hI1YOnQabQKoQdFmDzQZi55Gv0HJ65Xx4JcQXKmYxf5N8Nw\\\\\\\\\\\\\\\/+iZ1I17vRCD9sP73Uv9rSEpujL\\\\\\\\\\\\\\\/eF4lG3lfaANIiNk9THETHs1NZCd33KPj1NKnj0iRBujKhUVTX9Aobje51cdWDVVrq6skiuks5ZGVvQKk9aCk0rUsNYHnbpxd1pw6FpKJGI5ak+MDg6xoqB20Eg78HqX3Sfbmw+thCe5fmQ9RbovuZ0CnaftiLCh2DrsgWQnIAgloHzbuqAunGG5frewIr36FJzuaUOhJ1dMP6IJyFq9TyTm64nPYw47MTFiTZoNzBXYauEJ53BZ7hgdmYlcvFCvOLk0fgdy9bVfEmHrX9OVYYABtxoFduVyig3DmaDc8REHuLPqwQ+49+MqJ4e28wCskCkj8\\\\\\\\\\\\\\\/yi4VVqQ9RcXNvg9HFSSq+M\\\\\\\\\\\\\\\/RkfBiA6\\\\\\\\\\\\\\\/NRACMDu5eBgS76foSlCJ5oeyMs9EE2dTBAjfGGJi8QT6nL3j3U2aV204p+EdJVWim3IfdBGJbQvbHo9BJERPBnr5gDItluyJOGUOVM0Y4NGKbXzZdULAn0ii8CEB1k10nz9JJo7mle7hZ4Yc99+cQf6XFGx7XxvYV1gaUSo6DEE9wF22bEGu7f+fJNGAD0ugsmxhsWuO1YnAXS0vwZScuSACkhbaLZQBqiabmwljNJCZWG+648JEhze1GvPv6wdnqruSwGGvsyHk+vrMRlU4q9INm4VGL\\\\\\\\\\\\\\\/YyUjYNuhz0uxMHHPkdEJFsUau9iEOIBxk4qDLRhoplX7GoOQs3PaZ5dOXjOsy\\\\\\\\\\\\\\\/JLLs990M5UFugCntaS\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/nwjHfpXC3qGRe+plOQgQmWk4q+nkMnPL9kwAL9dTmL7L1h5w4a2QYnNQ5yQ4AeUIvGqE3TxLQEE08ZgOQQP8vAMMXDTNeS+n86CoIfB1wTTbEwF9vP4aBC9xJT\\\\\\\\\\\\\\\/TgD\\\\\\\\\\\\\\\/ZJm53bl4LcCnS0S9L7BJJb8IQgDq+Al2m8BgZu61eidYjD2fUgCUeKvLE28T1nf9vUgQ5lkJ2FdE24W3CtfGkNp5RvLIgUhcPhmNBohlo1VmMl2KAiIpnsNpROMcL90L8XvvQGUT3i4Fj+nF85t6V4wLztHW+xgxXFAGmH1vsf2barvwsXxJ44DGn6WlnsW1168JZSHb\\\\\\\\\\\\\\\/9MIJsm4zk\\\\\\\\\\\\\\\/6ZGIAtE8t8FaFCeiet6YM0TmYqCtC0bLIs82W4Axb4aLLdCWXRg7KCJJoSaZq2YsyWyph2wrByq3SOedpO2wKjYD+atpKNQCk41cu4pKwfimuVAnoSpts7atkq4fITLqAmmSfZQIJiPbyNiFl5e8AtmtPQl966mx5PhwV+\\\\\\\\\\\\\\\/BeK9NTlQi3t2nYPNpYlTjzJAjT75gkUf6JbAEcboI6sqMYLZPsxZrU7a5pjw+bW85evWkvj+h2jzX2QgBp3UpsNqyN8nOHuCpLEWqW+7BwY+cG5ytcaxBoBaxEb4hxEj4deZTWNy9gvZlBXBPTADkJQxgDJrtiOfUH6cqHP15cLVj2hYslDr3JmgEX3k2N5GGvMFBBEfKCz1Kl4iQHZ0111ssJKF5bU18HOAaSt2q68P0d7o4XTLaaQ1yN4\\\\\\\\\\\\\\\/8YYECWJ+dKNQnkkOChoQJiC+WfjnLo6UDnIgwFL7naINVP3z5\\\\\\\\\\\\\\\/dkKAwaOKZDoPU9FuthlaWjmA2w0N+wI+HrW65kjeLxTe9PUqjVnvAbpvRx0DU+VYUthD1P0zm1Da0v3Bn5LlFMe4AMJEJkP97LWylXD61U+ukHWKEPe9+PyhqHAOL7R07ZIioIrIxWFFbQbLkW47iEaSVfsd1+f2FCLNAnjkIAsVMqQd3ejqJK485wyjPXL\\\\\\\\\\\\\\\/hzWqMbpKitj3omLmDZCMPRYwCo1bx+3RjlqGK6OxXrEcD7Vbdc\\\\\\\\\\\\\\\/8W8jyQJuWQvHZR4crXih1BcoUhZyq5o7p+vb0ortyjTzTh5gv8pQK+fB63qbJ0myJEk2TPGYFJU4cCy2bS5V2uj241b\\\\\\\\\\\\\\\/c3YgOJVJUVhDjQLGO2iimSpXJFlka9p1+Y7Bj7f165l4638ij8g0zKc\\\\\\\\\\\\\\\/4u+bUQF+LP+WdKBXbcrTjBA53TM6dkZyFyjRFPHoYwvAMcDK76fJ+rDGIRWE\\\\\\\\\\\\\\\/ecIIwS5TzgOxZbppKo3S4yO2Hi5BwqeflFYV9VEe5VeYjVXW+xNjSJAJs6G7bSKPWnMjY5cZsp6xFOetIkPYK1zGKa+of2Abi6SCx+NyTOkcYdTXDEm\\\\\\\\\\\\\\\/MhED\\\\\\\\\\\\\\\/xlcH3gePk0OVOz4X2id\\\\\\\\\\\\\\\/v8pbrdtdYno4FfbAS9qXWSAnyyfUnljL+xtKiGIFuKZKEQLUwwMct2T0+1U2BUskdEXiAd+VNYPFQ0uJLDncju2OT3xmUAdCBeDnmb+i9rJcdZb4tifJh2S07rbMsRViK\\\\\\\\\\\\\\\/80AKIWPgDEshyY+Kp3PXZRJzMKqRk\\\\\\\\\\\\\\\/sSEyJTyolpKcIlQFa+6AI\\\\\\\\\\\\\\\/Ei9xneS\\\\\\\\\\\\\\\/1bUazLlofQVnxAMACs1LdLdGipq2wsY1Sv4T5o+kb\\\\\\\\\\\\\\\/WjgVJNdImrGdCTAwqw4zLnbMuKDCfDjqS+XnZgY7QWCYRMHMeYvE\\\\\\\\\\\\\\\/fHMWwn9cV3xdhA+FvghuMisFHiWlHi6ysxE+JreWm\\\\\\\\\\\\\\\/B8VElyQvk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229gWH+OLWQonsUvnA\\\\\\\\\\\\\\\/BvgDQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022be249a0a0207fc84191498f95bb10bcc451c3456efedffb84c351c4749f2dbff\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004512.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004512.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004512\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004512\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004512\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}