{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022zAA\\\\\\\\\\\\\\\/+QXcS2DFnVUdwM9fY3l+mNdhDQcfR3lwfIUfNtzw0HfLrqKU1tqBuRhDQVH0Ovaz1HYiPeG3FJK1TbhFW\\\\\\\\\\\\\\\/72vTlnDHpX8cw3JlJDK16EFuAjqve0jSBdiRfbFaRdcjt5iPaovM2fPGJNkz7SkcT3DyeMQbq6AvVJ9xpZ6wwJ4Pm6o4TzPibW96yfnuyfRnWtsrRBucsxsuE6ZxhaG29AoU8wRXDkuquJowFdTDjdrvYVrj6xU1y+bA\\\\\\\\\\\\\\\/BlZJrhqgqAV1uc7ZS0MpB6OUI9867ZHb4G0wIsHcdlTlInZJ+JbZ4BrfnMk6zYiHD9CHR75N8\\\\\\\\\\\\\\\/leF69Ta\\\\\\\\\\\\\\\/pxOJ\\\\\\\\\\\\\\\/0pHCGvwkVcoaWP74iI5mf6bp5ivfRvrSUnAy\\\\\\\\\\\\\\\/HwxV80L6+xrD8Ef7SJksLQfR0hY8MfRX9J2o4cw9VzlMDsZ0XxjflMk7sQ3RcvmPQvY\\\\\\\\\\\\\\\/nyFmdEAXOg7C9+QSXi\\\\\\\\\\\\\\\/bB8Vz\\\\\\\\\\\\\\\/H+pWITsoHM24CkgVXis2DrGVBE9Mqy1yoP+ErG2ncqgX+LPDZ\\\\\\\\\\\\\\\/+TbumBEzvkMy\\\\\\\\\\\\\\\/P3Su4LgP5XXhWOo2VnBo15ecN9qZtSvUqfCi3LNWC+B7LEGH4fAdGff9xSKNxpkLu2xvE56iHDvQF+upbWJtHNzA+xxbU\\\\\\\\\\\\\\\/RJij3wZsu+f4o6IKLY7ymgUpK6jZ+6IwXVEp5nYInUPjgsTX3+OtMMH3otkRk4dtyHyq1HOrrtoSbDH7Q2\\\\\\\\\\\\\\\/8KUSii+KpK5AbuaeSw5uMA1W239YHyvPbB+a5Nxz40V1+Fw1hM29eFfti8AU0LEwQTq3djql\\\\\\\\\\\\\\\/h++piC\\\\\\\\\\\\\\\/G+li7D8SxNRTLD+ZVZMUGhy1HzbN12u1uWJ3AspFDqz+gS4L3YTxg01JREl6WmdlLkYjk9oxIud+rqfPnXcY21AWGH5ezKkowfI2ilIIAxaxIuLJdWRGSEVYbYBYVMhb1QUnQGDYg\\\\\\\\\\\\\\\/9g3YKQ3W4M9uUuO0c94HMjKP95hx9ALb0G\\\\\\\\\\\\\\\/Xi4lbINUKBj\\\\\\\\\\\\\\\/dyULYiFdwMq+WNIZNi+FeakLkffjKpOtJMw4KufVSx98LC+Axj8NUgM5j+mAmCixdcaLx77Cj9spIU\\\\\\\\\\\\\\\/WdxWX6\\\\\\\\\\\\\\\/lpQMVG+iCrRmRo6eS8JtX6m0Cr28oRgHhAJ3PbrvMvsdNfFzDfMhZQhd2EleQ5IuRuNNBd1G2zm7+rjhzEORxMZ5bUqfnt58zCOC\\\\\\\\\\\\\\\/DewwMMxAanfOYVyRXCNmeUz5hgC4hfZZlqhpr4wqNbESPKR+sUjFvXhuaHRYwMM\\\\\\\\\\\\\\\/Bb4Lj+iAVASbPG1DRM\\\\\\\\\\\\\\\/FinWNWDuDztl0uiO\\\\\\\\\\\\\\\/uy68GAujCOHlkvQMA9iTUSV8+Hvf\\\\\\\\\\\\\\\/2q4IOJ332sQK1h2zLkmLgyR0geB7pWL9BoWZjeuCtmoeoH1IJlK4GyWE9r7j9B8Pc8qwkgMeqlD+nv6OkxoxFav1F3EOoWNAwwPl824MuIjAuDwMHr50BM6zD0tAx9fmhhpKYXxh53Lf8pMqM3ZUKHE+txrjgy3iOm8Zuru8ab8x6t2u2rEFNTWZUFoZMYhL34rBKfu4qD572vyiD7Rd\\\\\\\\\\\\\\\/Lvmj4Hr3XnspavJPry5NY4ZDTu9m49FpalTpr\\\\\\\\\\\\\\\/IqDKdtsGrBIw5nC59pYgGLHx\\\\\\\\\\\\\\\/IplMKiORArzNpVHpwgpWs5EAvgrzz5bUy1HVwBI9kAITy3DaZLA3Rj56sS83QKEcAhsF2G6lY0PLSC7lA7qHmtXW1RJRI8oDx61iMwXeQ0CRIXqHJLVHOr\\\\\\\\\\\\\\\/fRHxDodYX74TAIGIoTHI5AqdPkq6uOIdr0Z5yWVYZvluDAU6mmrZBSFbxfd7bKnl\\\\\\\\\\\\\\\/VVUnh3zNy5zISfPNe0VMWU7WGhIIv4NgU4tx8FO\\\\\\\\\\\\\\\/GQ892LKHkh1S96sRpaA2+xtipT0TRpuz9mJ7Gw3h8VvCULfubPyoYZBP8U\\\\\\\\\\\\\\\/AR7WGb5mz5hz3GfC4ytEkYlXh7jPnOIdCPZ4+hWTNHLRrdl3zuGLcxJqOYlhOSIAT4fAlxV50NhDneYBtJ3V2VZOhwb7jC3at4AZB5johBasN4XG3w97gyIPBQdV2cj8up5VDiNmqF7F7zxTd\\\\\\\\\\\\\\\/nAiOfs3yyelm\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/OW10brOX\\\\\\\\\\\\\\\/dcHMGZHhOITUAf1yZyFsQnFmhj5HtP9hsVabZ+yJB0RresiR7iyrwBtBZYUlkd2G0RaEn8wrw8lYLk8ebWbSauX5D7XNs\\\\\\\\\\\\\\\/k04FZsE+pzbu+Ik6sjpNMlkXvypcnqKGICmY3Ae9Gwz8nymb+T24eoFU16e\\\\\\\\\\\\\\\/osaGJIUxPDzM0BT0VOgNK5EXVdCuS61q8lVBvj66vcnpsLeb+shb2NTTct6tQAwXsKCsUBbgYtZO0P7JoXIajC+wg527pblXXff3uJRuW773m4qS2CXj6qcBv4VnWtf\\\\\\\\\\\\\\\/8dveLF8bV4TVmCXDDFOl56vax2iPqgujgqM\\\\\\\\\\\\\\\/rNWVCxsxiThsFkGNf3HBH20bLicQjg663fvjAEjYeAWi8cP7ZJC+2Nw7aQIL5Oj6\\\\\\\\\\\\\\\/RsIjjxq5RjWMHZR8tmgToYJyWjqND7OmDkTPUvRF3dbh6iNLzcOM0JiqfNROnpGFtgzVTpBsj6P2RMRIeX\\\\\\\\\\\\\\\/0x2SGWNnnLMHB3QfLsSiFNZxwRSOJ5+uCUBzEHLJCBOqksLrVXp\\\\\\\\\\\\\\\/QYzrn9IQotKisrMVbnNipdjw7AfD57\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/q9X089zqZ6Azl3C5oNMZXZ558APScAQwqHIg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lb+N\\\\\\\\\\\\\\\/T1Jewp0Z8FoWt3v8w==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022c4d658d236ad5e95cd617ea5296a03718ac5edaf5b9ac25d5255d8cabf9b7140\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/6\\\/e004291corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/6\\\/e004291corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/6\\\/e004291corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004291corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004291corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004291corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}