{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022FSycz0kuQuUCUL0r+w\\\\\\\\\\\\\\\/DDdbcaKOWUnyeUQks+1ZWV1hVI+YkIo7NRvLfhGijRECNZ8Swl0P56ty5XoXaABUNUtuzc97xoc1P0oemK9tgDjrDk6DRWo0PxtExxQG1zZNCG41HVJ3iz0Pbr2EZJrVksfUzV0+SKyAbYblvt8mZFwcYeQv9UDHMaL2RXK8cFTaBx56EQWYo1jnY3HCdd1\\\\\\\\\\\\\\\/ZzdjP5S+DsFJstaREMh36x\\\\\\\\\\\\\\\/Bkztjcox5Pu7iGYW99t5qbN5bSi88SI\\\\\\\\\\\\\\\/9ooaJ3VBdqzVPOVapsIdmlw71t2Q5j0\\\\\\\\\\\\\\\/u6SegeFNvn\\\\\\\\\\\\\\\/rzmVcE\\\\\\\\\\\\\\\/kZhuH+jDX5\\\\\\\\\\\\\\\/4tcWL0NYt+rg8ueN3jom0w0zrRlxfC3LXjdXEtzoJ0HzjEoY\\\\\\\\\\\\\\\/MjC3aEqyxm4yPFKM9v8AiVrzU9HSHsQIObwpvLAO\\\\\\\\\\\\\\\/CgoGrR\\\\\\\\\\\\\\\/M6FUghfs26U0W3bULaaSORDj9AmZIdvojmaEYkk0rUVfkTOtvkP5MEcUR86DifaPuWjvuIV1o\\\\\\\\\\\\\\\/5+sWQREWyX1r2dbtL9hBF+xx2tfHkHG99Qgtnl\\\\\\\\\\\\\\\/Vd8brGOtmvqmN+LZ7j+uAIPePHWJ2S7avTIgg6VUMPTqCtq7evPJ5EmVtlR7W\\\\\\\\\\\\\\\/Hok5kbv08Lnp89fvB9t1jhNm2wiAhXcrZfdpZJwEFVzdBCNm31AYH+kXQ5pbCAf4B0Shiub2rPHd\\\\\\\\\\\\\\\/a81DOFxRyVC0l9H8Y8sf9eIjRA2ak5O3tLDcG65O2Aq9hpUwqxCX2ky2W0FZJqGiHZfEmkW34jp4HJjPqhTHC703JF1V4eYoktdLf+binxJw0ng+3d48UEi9OUNiCuQ6PpZK7D6kywPF3x3zE\\\\\\\\\\\\\\\/RhUteq0s2EWAg7LKbJx2aTfW3sE27sxGH\\\\\\\\\\\\\\\/YALi1G3pqqKPxGIMzTnGHmAtvzT+ZL4EOyGN+n0\\\\\\\\\\\\\\\/8Rp9e6F+a6FOT5LJQYxmLW87AYODE3\\\\\\\\\\\\\\\/xC05KWwVn2wthB\\\\\\\\\\\\\\\/d0LXupKQsMYG0Ypw06dToJGqb+knFq6fv58Q\\\\\\\\\\\\\\\/fD3uxdrt0OSIVskMQseUUka919eR6nYzE9v1rCeGiFJEgHDdcDj+oVuUzNFuE\\\\\\\\\\\\\\\/EZ4m2h4hC1RA9cHPbN6xVtKyEquSBKDtq7yKP8cC5qhunGZ5wCJB6aGo3YaPDke2n4Upgdrre\\\\\\\\\\\\\\\/5C6zYCJC4E7PoLbB1KSoy7binzcDiB8xaZ2Nbq+yjkbha0f7+AaoDeZBufP9KHu9c2XMN\\\\\\\\\\\\\\\/oysyjIjEnFzFZetz6ETmirUNWe8vVSIeRWUxb1a+eHIlfCj+5hvhW6dSW+ji4ll0aaIbGsvXMrfCmefWnAR9RfH060i1EIrtf36FhUoTY6t3S4txP9+b0QbyauvHpndXvn9R2\\\\\\\\\\\\\\\/Hyf06Okk0UUPSi26y8Ig+mYT9SmOdHr0O5EBey6M+QTGrwZ2QC6OUjmAWmn0KFw0ZCZH+ghaoomkgngLag4s3GptnZMPy9TdSMcjfJaOXwuUgq5WutL8Tcx2Ci30chycoImfyoSZ9DPjFGyqWnjtzYr1Fw8wp9sBd9JSEOMOZW2nqeQ+eVmARzr6QCM79MlH8oIbISL1oKNTUEL5C1I3Ick2vdwTHWY83zENcoEBVOEFzAq1FFwR3SCk0Zg8w\\\\\\\\\\\\\\\/63XBrhb2ovQPoMy02469H+xu2qQi3sQtJLE1lYSIjK5\\\\\\\\\\\\\\\/weyErlDrYcnwRoxkPTWtKhQaWJE9zUxcQut93BSsuTXoZc65du0ymssJysmd5IwFCm2uvIJApwAN4pRYPe+wt3zsAsJKQ\\\\\\\\\\\\\\\/+QCh1Gp83R0ORe4\\\\\\\\\\\\\\\/1ehrdCSorLq5wwYFvjI\\\\\\\\\\\\\\\/mVaYDPFGvX12+nOGgI7im8a0CWMtEnWJcyKJsJh7snx2VrVwBhK8g19BOYskPL4Z8PbpqWBUEJf8kU6SqJcBLQs8j08TuhMsFwnpqrwyFtvCZNp7q9ram0FJ2I2AvsOzGGMoNxM7ZXvcgPfBCdtbMavW\\\\\\\\\\\\\\\/gM4irBgwP\\\\\\\\\\\\\\\/ZftYnPBwdDV1U+MWBKRyfZ3eWVkNQx80yYtCFqOhGbI\\\\\\\\\\\\\\\/wHl17lmn+6BSaJB7A5z7s1jyXgxDdBiaZnOz1s29reSZic6MBfGTZyyYIySeGSvbYHDzgh3OOatGE\\\\\\\\\\\\\\\/6bDbWq6vceqttmjQdz6BEV4sAqmISsbQV6Ir\\\\\\\\\\\\\\\/zqRO8o8xtlrAtkXI\\\\\\\\\\\\\\\/DhQ6QEpV7Fuc2zc\\\\\\\\\\\\\\\/HcwXxcA3syLFlNqDOpVjUQZTz9xM6fV0zl9U83P+iLVntQh87PP6Z9lBhb1LyWp8ok7hEPvOR6Jg7hpAk1rSG7HGks2gBOfX13aBMKJHIKhcbthY1N99HEFcxrL4ToCG3AwYs0BjmBIarf7bI6rEOr6gUzAV3e9qHV+CU4jD1HbTNkGkgwvbOXJDjknvot5uXsi5qhPumoHJxpk0pmC\\\\\\\\\\\\\\\/6cwHuWXoZ\\\\\\\\\\\\\\\/wnbYLEtT1y+ZKkQoNp5C00z+kug6tSb1O1DeuRmwM6AvNkb\\\\\\\\\\\\\\\/S997Ix\\\\\\\\\\\\\\\/oguln7TN1b5saRlWGJgrjtwc8aF61yl8L\\\\\\\\\\\\\\\/PNnesDc3b0WCysQotIytIR5VW4fCkOZQtRffdJeDKF5PAA0i5t3uFWwZewop\\\\\\\\\\\\\\\/3kfsFcpm+r+duOX+ehD0wB7m5Q4QIW+l7xV1nwB6BlccyC1auboEcmHwaIHwCKFV2SiuXpHhzDGt3ZiK\\\\\\\\\\\\\\\/o2vUfzDRYhFhgf5ZlU5\\\\\\\\\\\\\\\/DPcQ6QnoOX\\\\\\\\\\\\\\\/2mT5xUIS\\\\\\\\\\\\\\\/6DylwChk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XgWzrc6ys543WFoU7mzLqQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222333449e8adb3ba1e75d8cde598fdf767501906601201eadfbefd0a06d71a029\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/5\\\/e004338.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/5\\\/e004338.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004338\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004338\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004338\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}