{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022HW+hlCvkGoP+w+n2DBxt4SStXu1wpAu+UnDrsJLaOyKqwK9z\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/qwAhwW9SSjCJPtDsPH3xlwsnWfKvxbaub5pR6zyKeyHLfPh7xkNY+Nn5yNy528b1\\\\\\\\\\\\\\\/PKr1l5rHue9e24ZNCqmTGphsq9QPR1EIyLk4bSoMSeyWXxZeF\\\\\\\\\\\\\\\/ip1j0q2T7GlVpTTfcgFl3tNlixB7usn+ys0W7UbV6FPctBL0RBvX23hwmZFDKazZzNI52sENGMqRncTDtWGiRdNAqSeaZJzvPeh6fPnwDCjSH3PcU3bhl0WGtOrQVZqhfM890lO\\\\\\\\\\\\\\\/FWzB6HsfvQV0ALXYPOAe67m8tPxkXm62PkjheCs0nWY32+xKFKXixptKHMOghcYxtP42RHgk4BmXEh4HtQldckAigenIvHPaZLGZTCwAK7mqZe8lP+tpa1sdYMm8pubfpizWLvdRRNzSkaQxioKBEiyFkSOSJv19aph65X4ebCL2DgOfvZ8rTOR8qrvG+OTmT8VZSYIhE5YG65Iej0DVf\\\\\\\\\\\\\\\/7UNbrlhHiye1\\\\\\\\\\\\\\\/JjezgYiGAoCqMoxhGnuGI+exg1vupVDwXdNOHmAw0juPYNAShu7VXHLja3l10H0nRcZ8ccSv41HsW2FA2GY5wcHuP4IFfig4schUKFWaPdlPRvczwGUMPRS3sH4jmxuxAFuGy5sDubwz\\\\\\\\\\\\\\\/HHs7vi2VeVVi07HTQDFqtVO1WNSDgmL7QQVox20\\\\\\\\\\\\\\\/taIRiDtyXz5jIvxwh+vMGo3pvecyBZMpvsA3XQFENo0oCtHl3p2f44XVmRo77CmYQFlj4uRcKC4JuvNUoJmQM\\\\\\\\\\\\\\\/Ar\\\\\\\\\\\\\\\/4NSUCLATBwW5BN59UXWKO+IcYmC0lNeS0Lv18khDKUJ37hWxqC5WbCTIFgIjPj6xCA3v6bXpZD+7OnAgLGC1rAuNh5\\\\\\\\\\\\\\\/UuKUvxPhauaAS14G5EKkfF6+JOM500A23dZEnuo3fqKIthegxmUkh0F3t034GHgQK1AA3tVs5KWiq6+ChrunL541DkUvFHadNPawwdhzSernQ4qxAiFKB2\\\\\\\\\\\\\\\/sA0qZLBZp3Wvj5gOoCtYY2wgeSBCN7o+r1xcBJVfh\\\\\\\\\\\\\\\/H6uzwAj+2sqYnXdkWaZHphph8\\\\\\\\\\\\\\\/xp6kmth\\\\\\\\\\\\\\\/V+nZYENAH3HuGfA\\\\\\\\\\\\\\\/6YD+TkvDjwgZEnhk5u6XfynUpYvjFoXD14qw2hSLpKSHg6tB4\\\\\\\\\\\\\\\/k3amLbIAds+kUynUH2X\\\\\\\\\\\\\\\/LcRysiLGEI0E3zm0OZ+oS70Tdq4ttpNe5PX1LBryw9EYAJ9mkJGWBrod2WrFSFGGbTvE9e9I4U7ie\\\\\\\\\\\\\\\/e05hsHdy70Lhlz4ye4sXTJ7mJZA1tYy5rGk8EjVcxlRgedr1NcS\\\\\\\\\\\\\\\/YYj5LniS77+eNGWSJpFqNh2lRwUNRYqPcSuSGxsk54+Vk\\\\\\\\\\\\\\\/x9cf2KmLV3sV+xdEvPRiRIboaKDiI9LmwtPEP\\\\\\\\\\\\\\\/fPHT3qOxaPIdENL9BrmPU3ugNudK28dkuZA8qPhsCKcjvBgQm0kf7P8LJ6KYh7peGQS06bvdxIDQsYVw0gpUyYeW6rPSvvgq+J8XA8yB\\\\\\\\\\\\\\\/OZUKPBlGZWqLi8mzPYE0EUFiayQrOYVOwcyFiFRYSPU9uhUU9DOvTpW4u2SX0CEtRb1KluBx2nH6YXevprDYxe4ZB22DxkExd95D52oTMVj+yYOUlqB5O1MybDne+HI1MKbvM7pa07yz2HoPgzlxFg+2emytnsz6B\\\\\\\\\\\\\\\/PaxWWH8lipZtzXNg6E57KJRuCj3zecmuWbr9ge\\\\\\\\\\\\\\\/CPlZiJqXbigDxhT5btXLI3c4EELuZAdqHW\\\\\\\\\\\\\\\/GS340pnwbtvDvaa14lHl\\\\\\\\\\\\\\\/2cpN+YnHsaA963OGHY\\\\\\\\\\\\\\\/vFGdT049w5sZzdqUgM9deEwBVOy7VX8VT80EbN2\\\\\\\\\\\\\\\/D8w9kYSxsiGjw5BjKDwn+8cwqecEsYvYZUhamhDgSt1YYWOWxmuOBq+XT9qAs46u9\\\\\\\\\\\\\\\/UDFw1u69nDVDPda6\\\\\\\\\\\\\\\/Ci7iXKuPIKfAJyfZcQUIv\\\\\\\\\\\\\\\/2JMsWEmdr3JvriuLSoyyHsNXxZlF2EGCZ17nufsnhsVufdgJShOz64glXfntcBJP1rKPr+9aqDWYfW2O1un4XyBhW24wbmmni7K4misjifEzRffPSdVTLz2xHtEjFcNYD7uStISDlhLLCkx2HXN\\\\\\\\\\\\\\\/fmoqvj8Z9U5msq8uFE\\\\\\\\\\\\\\\/Q2CExsWdZHgoItwLMGLQ9gyB4DLCmduxvuk07sV9BzEwdbD\\\\\\\\\\\\\\\/E7thdXH3ZxkEiFiuN+PxuDq+bKIrurBzZTF4a1Hipz8a1wZ5CncwTkWoTBRXiXd2cVneeY4IanWBYQIt+uJhWXHwhxARM0WVxaXhd+5zI+Z\\\\\\\\\\\\\\\/Ewzk1q0BYUdKP9MlCjLzxmPHCLXObJFBTTnsZf2He8+rmqwfdl9G\\\\\\\\\\\\\\\/QdjecoYrzS7W+2dbUferO3AbmG6wzsDeeD9hVza4MGG7WUx6F+8jUYUxwspfMyIUfEiKJI0yoVruMOUOqppgT9CPq\\\\\\\\\\\\\\\/YwNXzcUb6Ja1w9TPoOkk1vYlb1xTM8KzjQGhNJ7xb538NLLwW9eBsqWR08f+kxwyTj67Y4lOhx0qgKKGzcmgE9RmsaWUTeokYk\\\\\\\\\\\\\\\/hStjpoKxj1rsKv3JNGVxd+MPfLYpFrgH\\\\\\\\\\\\\\\/HEKVLvmJQKX1U5hkAtnrOomngmvIzITdCfq+qtYW7UG9Xwbn4RvoEhSAIJ6m26IBzMdmjr6Losoqufullgi6A1\\\\\\\\\\\\\\\/1exC0ss=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ftKpOtkCSinni\\\\\\\\\\\\\\\/HRi8JRag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a8bf7b3e5afa49d8804025423fd78479a11abe80bfd008563ebc38eb5044374f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/5\\\/e004475.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/5\\\/e004475.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004475\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004475\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004475\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}