{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00225M6gN4kEFUcXlpDYHnxl1jRKK91Vla7qBuM56mnt2DgyJhuyKd\\\\\\\\\\\\\\\/U5K0EvoHhlKyCPr6+cvSVPsCfgJ47yPHq\\\\\\\\\\\\\\\/j9jUYoOFGvyTIvkUdc+ss2+u37uf3fklP7SyOI1D6zGp0jhDs5EOvw8UoP+Hw6vTL8nhvaQm+mnwZ+ZvhWHClBNvUxqg8DiAbAS33fs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/IMrbVLOJmbpc\\\\\\\\\\\\\\\/eGHsQ+LixTOVmDMiaeP4i9juC0gqN1cp4hI9HJ9hK34DKtP+G9H9xEN5WH+vXOEe71iGOKE1awTWtcg7RlzS+gEgfH\\\\\\\\\\\\\\\/lqozXJOb3k6SGOgRqSXCRq\\\\\\\\\\\\\\\/Y4zj1QVc5VRtu\\\\\\\\\\\\\\\/x7e\\\\\\\\\\\\\\\/PolUS79Fpn0hmq7q98B6vFOmIriCbfr8RdSfMAwX1mwslDsGQzgiPlqs\\\\\\\\\\\\\\\/YcWsAiD0S1BT2UcGeNu7FR7q7wSvQWQHbYncEWfsXj+kTnb2r3vK9+3Bmfyj892AxtlkdvQAwlNrGrT1qHrmraiEc42fC+VyTfkxUUAOI46B\\\\\\\\\\\\\\\/YWHzx4jzafuyZihVIN8duJbQf1dntrDcX1J5Lfq29meEBMXg4J+0UxIeU74RMeIiuSIeB2oYfxcHxJZSQlX4rvuWPv7fX7fcbnSLyl\\\\\\\\\\\\\\\/HY7L2pqP0axi2577O5GzzLLz573xkYQ88pL3gysynJ6JLuKTHlEfKaKdTzYhxKChXAyBWcM9HRT2+Fj5mRUlf\\\\\\\\\\\\\\\/gd\\\\\\\\\\\\\\\/lQsJzvRcjvTicmP6OZdn6qegeur7DHlGeMM\\\\\\\\\\\\\\\/LoGU9DI1ulwKpXlCRDWun82+ZTiRJO+lwDfz18UbX\\\\\\\\\\\\\\\/jU5mlEJTm19KoY0PuZUijzdOG6zZsWUgDVlecwksjgRjnujHBfX9uyZLFRYxv44OnZ8XqWCG52fIbPUKvaA23WPr8AQO6EUw4zaX\\\\\\\\\\\\\\\/B5Gatjz0QCxaaeFK1KAramw9F4troZMV5iz8FU6m6GzHQaR57VeeWpIsa0NGwzZCVqAIIdBSi5Eq0WOry576mJWz\\\\\\\\\\\\\\\/LOvnBqVdBxkzg9CGZLu0eJ+56BJWCCapIsxPn7plbxVrw4cshK19qo8Z\\\\\\\\\\\\\\\/LmhJ1zQARBejcSJecG72JGHEaDYPzFQ2X8gpv9e3ktTmBaZvBO50ELFSNO8AcPCNA0aF7Af4Bl3\\\\\\\\\\\\\\\/AXgG6P9IV04rOdwMLtQQ2jST20YoxaYbV99+NO78sFtlPKWKeMe+krkl9KCZ6K3emCTKffUa5jOZbuaLvJUH7HiaDjTzK2yPoLKaRBovcy2VXaX9jmpj5KxuHNu6DHCTrApHvPjy4ZLPYUXZCjkI1EkrFAUenrlQZrI48Zlu1C37ob9uBRf\\\\\\\\\\\\\\\/OwgQVEnVtb2s3kTSINRuI21T2NacJ4PZEF\\\\\\\\\\\\\\\/1n7cJ8BkyJ4OW+rrsMGk+EbFEnF6zZjnLaYIUqSyAYjCIvXIlSEzgoF1Iy18\\\\\\\\\\\\\\\/ins59DuwzF7hlxx1tNK+HlA2n98+fDzjE8lACP12VxNNf+71sQaIgmOl3hgUw\\\\\\\\\\\\\\\/CFH714wDZ8rHvfHleKrNG0DIZLzp3D6P90vn\\\\\\\\\\\\\\\/JB+UXDmT9rLp087g9b5p3FWReG1Vq+dArwo4rvoCFUj0PJ76tyi65hcjlXV7J8\\\\\\\\\\\\\\\/mxVxO6GZX5KmJkZWDqYYGRFyB5eXG3furyA58pFgiEXyKdNQj+sp2j8WWQ2Yuu0yRi318gKBW\\\\\\\\\\\\\\\/bVwVOsZOxo3pZM9YXa0vvfddoxfeHFfKw\\\\\\\\\\\\\\\/k4CrxPGitkSXbR0w4MenG2dQw03wl\\\\\\\\\\\\\\\/8xWtc\\\\\\\\\\\\\\\/sAoCxz5HP0B9Wbotz+TtfjWQ1KxPyttt9tuL6T4lGRcBpUZc21oGa1JSPqn7aUthO2DNh7B6GjG3+E7y4eWkA28zVm6B1VNx3OGe8n4YlJGrOsbg3vJcp19pMsDIaqSf7GLGpiig2FHzZq5kZLk4iEF2cGqSHX48P7Ent9ar1m1FelxGMMys4VYtyIEpJgvE6WWhr0Z7ejGz3bHOfap0TfoLudE6AxkIFUydQ6Ivmjj50fk+LomvFOfMFbLWRjiketwh5DM522\\\\\\\\\\\\\\\/MRc43EVfoXoi2kJJmVxwOAPyTPFP6fvnbdyid\\\\\\\\\\\\\\\/mQ2cZq0e7QRTp5OUf8S2QxAiMhcCbWme20lnZGWZws04Fu+vGj2jvM+DdpgREVjWlwKKx86egno6zxeX6gaW4KhmcVkqBfavXxpJoyhoZWfOOdF7k7FFmiGrIeJi0td8xYu2UYsDp8rketoQbhsqqgFo8KqXEWJv+R8LcyY04ZPcztRNBmQAJO5hAD9h160+0s7lwjb6m6x7P43pI\\\\\\\\\\\\\\\/M6SQIej4ItyyGg+qer+J\\\\\\\\\\\\\\\/Xsc02IEWWPAX\\\\\\\\\\\\\\\/byR28dhtEuTLingY60dpZlRaghVyFFiu3dmNbqyPrzr4PjpyJaLHrWNKtT7RAfC7nUc7nn7r76tluNQvOWOP86W8SFZ8MOSE5KCoId\\\\\\\\\\\\\\\/wPVnCXO5wiJ7KdqerNSckkCUF+Xs8GHfpMvgXGZtpue9+DXkY429vDCux\\\\\\\\\\\\\\\/kzLhwzfiQsvCs+CzUjUsO+zn2bvSkh26M\\\\\\\\\\\\\\\/GBIr0FW1r211L7uus6jfG2N4NsJI+JH6A1Y5vxfHzSSacPVRxtk38iLiDPOuR0ZaZ9\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/pRmeDpI9b3LxlonOFyuZgIVM\\\\\\\\\\\\\\\/7Aez6FvG4p68pUIdue+Ewu+Vs+3j2WsPkcSeATFOW++sb8do6GLdRPB4tBCxhXxPiDWFnjtTTYG22KvHk1isnyfGE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BZklv3WPDoWBHn9NmAdo4A==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022885b476e5f49c78abdefd789ce5d8a51c20b1b2a09fd5122ed25d10c2180d18a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/5\\\/e004592.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/5\\\/e004592.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2022-004592\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2022-004592\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2022-004592\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}