{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022NJCTZXaSs+Vrzh0dDjfBNfeCn9ekA8z6rjLlu8ZFDJ3iXko7nzEmmA87UYoxsQWMxdDFPjuf0eTZ56Zg4XkcedX7Z3TayxIkwWE0zBLK0ZZcFMq5B8gvcKzA1NuHtooYsVoF\\\\\\\\\\\\\\\/m3Ov8cMC1nUN8ilthk8OcA3l+jCl\\\\\\\\\\\\\\\/ZJe8g\\\\\\\\\\\\\\\/MWlk+WyS2UaP\\\\\\\\\\\\\\\/A2cxKUHT4YIz1Y5o7Qv7zCi63VuBmQkBDC9oeCCSj1M5VWJrxoVV6zR6YOPU9\\\\\\\\\\\\\\\/Ws\\\\\\\\\\\\\\\/LuKnxvKxV1\\\\\\\\\\\\\\\/qN2\\\\\\\\\\\\\\\/IPV8OuOb+LtF\\\\\\\\\\\\\\\/Q7RtWm3RJ9lU909yzILLjOp2k7mmwjUFLGL2+mP01xehUTWVCWgwGHBM1UnoqCvDFCZnTZQ3847XiTSu3Q1LLNSPuofBg9Twv2KDmwC71MsIRISl4bMajKKXCVc7sKtmDPoEGxd8dSi+2\\\\\\\\\\\\\\\/qNvcpD4L0+KkqF3Dp+WouLRiHZssf0SLULwkJ+YORufiEP2hkWxeOky7tA2RIKofjwpGioeQhVwAC7fka\\\\\\\\\\\\\\\/hW8Lh5QHbTQZDxaXCWAmqe3juKD0rEtBPbMBnVMR+9ZCsFBubpRgH2UqF\\\\\\\\\\\\\\\/+NOl4D2MFolOBRZVMiwslCy9SpmsZ\\\\\\\\\\\\\\\/oId\\\\\\\\\\\\\\\/UiXbK+zVQHEC6CAKvkFdkY12k8Cme1UZoGXTRTlfyteu0rxAHPLZB06bL8Od+vojezAdYClnxNSH4Xr4G7OF5ZjG0XsoqjuLAI3Pj1z8BhXlNZT4WMfnmPvwLMx+x+mDsvGvAr5SzYYWHnCEwVbIzhwjEfCV54K8QeQsAuMIVQBtbQdLJZ5NbOpyPpJlB86LFNo0KFtJSzwkTSyS9Biw9WToDirMPc3XHNLm1zmMdRiDHDNArFRN4KDG8Kf5Xm3i5Ust83odEpMtvuEw+kOdw82t\\\\\\\\\\\\\\\/lOurgVhtXn4rIvoEZVP+9Hy9oyZmhhW8V4nZKeRtzxTcBnsNEmv672QaK6pE0lyA5v02YfhAzxKQD9PZDghpXjOPc1TNQhghlp87H6cY8YMTjIRS\\\\\\\\\\\\\\\/Cpl2MUp3VEO2sFq4ZmgjGew2PCdhXwEhIB\\\\\\\\\\\\\\\/8Y\\\\\\\\\\\\\\\/2cv05W8Ajj7z\\\\\\\\\\\\\\\/ashr\\\\\\\\\\\\\\\/nCdOLcnwoiHTa53\\\\\\\\\\\\\\\/YdgPYsoXWNpz\\\\\\\\\\\\\\\/2QQWL3VrMEGItS54JMVCE9nsPfZkw5IsfjWj7fsOdoZqIBTE2bP\\\\\\\\\\\\\\\/T\\\\\\\\\\\\\\\/fRhworTGumSmjY9l2UBwTQrH63dHOu7EsGXuwCzpRIiUiUyaY4DEvw6NwDR3vTJHAJS7kA7\\\\\\\\\\\\\\\/eR7rXSVI9KhmNZNGgCCf0ExRViqFrMQtSten\\\\\\\\\\\\\\\/KOnVhPs7YaYzV1lHr880EyBaG6eZyNsymLuipls10r0KGXzCRVb1lIoDPMybiL2uilXu89Z1Z7RJAr+kZfrWG9B4UFz4Cv9thqjRMyNmi0t81fMJ1nTq0k0EHiguBJk19L27l3+smOwc2UazyS5TrKOpFKKxKM8WxKET7v+w5cmbo1259KdB8M2fjlnlWiTUPVtMC2IZODl2KO1iJelcUDLsLANHs5fwH06FXvXGeV5Wm5YxGKdDczTNx9Md0AoOXxKNzHKY\\\\\\\\\\\\\\\/A4MmkRIDbYTWOh2BY+HKxhuw3j6BPFnd2LSPhBVrulIMsBwVts5B9lubVyKqmZzv+FNGGKFpyR\\\\\\\\\\\\\\\/fpkzECE1tSvm1a0UtWPnY1YwWN6Klw3FdJ2Uvfn1JP5Ls2y+aOtsTL5soDf7WiMn663r1HFk3UuDNW+ONf\\\\\\\\\\\\\\\/Oi0VEuw7qDuOjOj5V0w8\\\\\\\\\\\\\\\/ez90nPTuYZ5bNlEIyX+WuYyMhLYU31764f50gFJdcd\\\\\\\\\\\\\\\/JkHjts3L2WzvS2A5kZm0cSYjXKpJ+GfRvfyS+k1xBGf0MBbJ2AeYYdfKCmCK0sY7bORWqZIWQPCLUohmVlZZsCR\\\\\\\\\\\\\\\/K7i1hzUYUGXcyMbxpfF8GXZ2kimrdSmOxhIS+eCJjR5sEPZF7QjHHJ978QS+X0MuqoVZ83vzYZrrf4n9Y+kNmH681nyfo\\\\\\\\\\\\\\\/E9DDXF3vGLhCFqT1MdC2OGdMfHGbYcVWpQffl+oHuiJBS6wuyNkfOmzN1c\\\\\\\\\\\\\\\/+AtptVWYxtROnFjOOO4x00SIBKHh0vZt5F+MozjSd5nFnLRPSN1wyB\\\\\\\\\\\\\\\/F3+9k8sjjAktKLqzD6WFTCLriPHk5EzlyYB\\\\\\\\\\\\\\\/BdYfcvExW3pfVYjjgPWFS+bmhdRoO7Kqt8k2bJXDZGInp5gtcIY1ZLayJJUOJRpoRSRVPR\\\\\\\\\\\\\\\/FrRzuDdwJ39MxFh3U4oyw+l81ursubCwlgFAsX2+rjHb7nZNz71RJ3POfEByvMsyocZPIgd7vnazFwV16XkIPpHMLcZ4xYxi\\\\\\\\\\\\\\\/p+RB2UMI+D\\\\\\\\\\\\\\\/t02f+3O23CL1rQQb2jdzuDdMQov6l51OP8h3LWDsO1doW2NvHHOirPOse0+kfDlIxq+FBcjGKYa5snejr9Pn+Ij5oIHpMIuq73\\\\\\\\\\\\\\\/WbRblrKEk6amti+r3v\\\\\\\\\\\\\\\/giqw2o47nM3YK00GE5Uq3+fpnQtk60dRTRK8vUjNIZNSAdJ9BLjqgu5jH+9Y\\\\\\\\\\\\\\\/dKokbD1bq4GdcbFBxpJpeuqsBerEDE0DIhKoR\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/VaAEBDGB1fNyTXr96P33ylOdfseQVoFA02TM5DdWIlk3Q534KOw8LAwY5jbUtxwmQ6FKf5MlwQk1pTlW5QNoUA\\\\\\\\\\\\\\\/vsoIvXloCtJuCzuBKkdn0wppP6IcIJqQSgZSisBQ0qYoFQYZ3rPl6LMzXzeRgDhCUDwU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022+x9bO627tjisKzFDUdC2Vw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022eea766ef03424cedcf7aedb1a53cce58c7b425dbda2399884b5c7d581ab8b1c1\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/4\\\/e000960corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/4\\\/e000960corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/4\\\/e000960corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-000960corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-000960corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-000960corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}