{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qOgacLoWMnDdPgS+\\\\\\\\\\\\\\\/3CwK2YARrGSQ+L+MbxNqu\\\\\\\\\\\\\\\/OBNnMjjqnyjIQ4b6IseEJCdRdapRYpZtBeGbWjR3s7wEh9MPpJFVUa5FrL4L6O0\\\\\\\\\\\\\\\/0fgfehFQYyhIlYlsS+3PV\\\\\\\\\\\\\\\/iL5At29+jucJoXkGKUdzB8dgB9C4\\\\\\\\\\\\\\\/bvex2BHGOll30LjpLWx5YYzav2WDrtQniBuWwI3ocOUaTdnyAqwCVJBtOoQPxd23rrpKVJE9zI9tJK+8V\\\\\\\\\\\\\\\/u551G\\\\\\\\\\\\\\\/QAteCcHC4vvtThKFaVHt2T5gaoPYXnN2rOGk4xa1kD9o\\\\\\\\\\\\\\\/pAwI6tKXy32WoYnTGID6CPejlc4+U5OEik5EQxleakvL\\\\\\\\\\\\\\\/MHkPi+P7gPnwTLNpmrjoSGtiQYhXa2NlnYyAyrs2Y2lj\\\\\\\\\\\\\\\/QpPcZUuUZ7mtQUaJ5LPfq371Hdjz7V3XGcVIcYC7M4D5\\\\\\\\\\\\\\\/J1UO6\\\\\\\\\\\\\\\/y6kbReTpFhwDeDpM2Ylm5tL4dDbRZxW7BxmoADUu4ptcOdnRTgxo8\\\\\\\\\\\\\\\/vyNjgLl7Vh7Mky3pzLzVtBP+ff7IiHdRbikxSLTYlTq3JxdK6oAwCwDtv7Bvpz+0BAXTp0EwJ8Xrx+LifoSgo0KfO0PbrwpvC3dc5wKxQVTuUCRZLgK26fILtRbq8P\\\\\\\\\\\\\\\/tEl+IdHzJ6aOueOpa6GNHDv4sHFYAP9gqCkoHgr3BduEu4CrM8oZc0Gb3zD41ECRkzkStVgVHp97GBEk0HR7M8HgfvHcgDdNXar0ElisxJrNpL3qCWGo+cBAHaUyB\\\\\\\\\\\\\\\/3h9wVAxd8cp9o82o7JeS0PfrCkfROz5T8TlCvpuhIQww8XIJ+Hrd2fAVX7d3yO2KLWKCd8gCYW0gAHPjfmBTMxZHTniNIcue6FDrHXwA\\\\\\\\\\\\\\\/2JGf3zdB+p0gk30tBl9cysABpQy8OzX4hmGHaJ9iqCDGiQev8vX7stK2bXeqE+OdrB0gKQ6iIDfe8LnZRIAB3s4XMcbi8MYInl6AUF0U7S6Sn751bOT0qd2DEGb6mOXSDnmK\\\\\\\\\\\\\\\/iSeL3OPYl8GDFcAv03XFf1cCLHF3o+Rg4TiLs+iQG6CGb07fQYjsqRtwjOXNqqPBTQBsT299YC5MXDnkGTc5VaJ9nzGnh5N1V6\\\\\\\\\\\\\\\/ys+ihMdQ9\\\\\\\\\\\\\\\/35H213lSOkKlN+rF4vL3nl+RBdq7cFwRQO5YyVVcdZSNomM2oBaXiJAd48HAjLb9h+LwDEwUrpMqlyZUBEG9Hu9wJk+5IMlCydeGLtb5NY3Pg8MI\\\\\\\\\\\\\\\/EsjxvO4h+a7Zj1BOoctI2kA\\\\\\\\\\\\\\\/D7k+tMdHSO+yNu0cXAi0+5fcEZzI4Adxj6PKeXFDqOcq0AFLm35bxAhY0zYitoI5f3WzWOQZ0Dr4aqm4MAyvIsfB3UPsxbnxhL3taYobXNXnF3983Afbp0Wuv\\\\\\\\\\\\\\\/miwG2cFoSkWnrPphMds2PE0y85+ORX7z5D1YVuK0uDkiaNF7gZJ9BVkKVoTBRHN2g9xiqe9GVZ7C1vkrwEmFAzllURHUJDofM1bu2V7pIM1INf0etdnlvv5zFNrWc+4ZhbEdJsvvJ5dnz4+N0MFaq8xyEHY+NKXFulxwPX7XqP1vpiCxNNIxH68Eud1TdJULSJ9syoxqldpNKQnKHTDdSAMjrQwNtz0BfYMDs9JE2fhwH3nXI7SeUIFN45pYWsLTpef44URXTOcKkr\\\\\\\\\\\\\\\/qoeSnXBpz\\\\\\\\\\\\\\\/VAxv0yYMplnoDOYHZCj2TiwgcVMxzAApHbVUtqIYyc\\\\\\\\\\\\\\\/Q4KxWlvRRluTDijkZZdaBMbbsQqjOA\\\\\\\\\\\\\\\/3aNmyr5PlknOoRgrW8bSr72mqgPYaOILxRDjvD1ZuFDMHfvR9gy+Gz\\\\\\\\\\\\\\\/e+sc8aRrxjOpGLCtRdgmAQLXB8Kgj9gZkhwHLVT\\\\\\\\\\\\\\\/5JrcH3aGnXRyBJ9uHNid8Q7LjBAf7WI6ht+qsS5puqdricLC36uVpGXv7ZmciiYvBVXH6K9iPikXKbLa1ukCjn1tOvOTdlkule+5WGI2VeOGaNUe4yFlYKbtO1WRIfl2E\\\\\\\\\\\\\\\/pi53OHQUdmynWMwkyaj5d3+rABkf4FJQegJdoKMq83tWHnRo27XldHmaA7qOJUhhn+bH8LYU+j40QvfTTQ7bunQpUOqqlpZzX7xcvdLSkYC5YP6MIdJW3KcaR\\\\\\\\\\\\\\\/ibz6gWnPocYB8opWYkRYbwI0mUDiV1lwxpm5pVJ\\\\\\\\\\\\\\\/XQBqMORwRWMbblJFq1\\\\\\\\\\\\\\\/EPy0A8UnPLqZWTE4jxWKVQ8j1sIWaxA8aW654OOfGlzSyI1zdAH4rPZeQ1W5eBhaG4fOLhw0R8LaPBLTYoQeE5U3Af1cQAYhUFfpNUuGiJydJXE4SAVd2n6DAA4xxxhQEYVYxfubGyv7QDsm8wDRuHbIdQ9wgT9j6wvC14YCerAjwGC6c+chR5zQ56bcHXLpFCL6Xz11vKEt3x1ErS4tl1xDYhfcJB9MiGnxZAb6EBI4w8LQSekNUjHQqam+GgDuLFUB2FeC\\\\\\\\\\\\\\\/xe7mSY6AEUEWnv7lA2M7Bwc\\\\\\\\\\\\\\\/i4sPkPRKhEQcJ5PJHCWMsVYaPn8cSmghc6WzE7fN5X8i3Nz3hEyUjy63sjHLstRY3G6VyMGGFdr\\\\\\\\\\\\\\\/SjYaPCbH1dA5SHVHXAOu9YCV7IoxBGjdZq0\\\\\\\\\\\\\\\/FxzksvNy2QjPGfBSHdSs03QjLgGbxcRIHR+1aHXGq8YnDmxM8eZ2sSRpCMCpkUBsoTgyn6ru8aGg7eXGf9zIJ30X1yclImxG9xt8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022jeaLJLJnh0WCR8FUgcKf+Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002221f5d6cdcb49ae4882e4031ccb3c19fd93850ebc354f0e7c222b56c6ce05f45a\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/4\\\/e004424.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/4\\\/e004424.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004424\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004424\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004424\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}