{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022YZSQWC3PuqnrOWv8MvMbuajYr6kmtbMzs2f1M+\\\\\\\\\\\\\\\/qXscHgSnKB9aMZUZrdpKyct6F8NF7YyzdJKXRvshQwm8Js6fA5rgpeO7E0qOCaK1dBx\\\\\\\\\\\\\\\/z3iqvRACDoA1Az9Xt\\\\\\\\\\\\\\\/cA985sVG\\\\\\\\\\\\\\\/141wUMbTqWovGspjS+1hE6N0wK166Z7tFoqihCou6nmgT6yAMJJrkJNq76sqenec5jzrbJL\\\\\\\\\\\\\\\/5UwPno12uUMpxxlDbSoTlQ+i5G7QEq+Gj0ROIwGB6MBuE3J0alfdNU4keDvNjM4vQxkwjrkS2f197MNa5vFIcuv7gLxpHYOWh8cA1wJ\\\\\\\\\\\\\\\/f3Xx87QlOG0CTAhP\\\\\\\\\\\\\\\/C+KOkZ2Ox9P\\\\\\\\\\\\\\\/ZzgMYFpKpJQK+hKjpS\\\\\\\\\\\\\\\/B62aQwI5\\\\\\\\\\\\\\\/QqVy\\\\\\\\\\\\\\\/iuxO\\\\\\\\\\\\\\\/vSdMqOsxp7B8wNf2+5xrg19NoMm95Bvtjq1yA\\\\\\\\\\\\\\\/suuxnkjCPEs0CEvW4+1eSNXbncx7B2DjapZWgIogUvBbUIVCpzFMxEhsp0btoxDWGkrh6IM\\\\\\\\\\\\\\\/q5vWSEvH\\\\\\\\\\\\\\\/qvt7FIC0LCA4kBItd4re6T+m5uoVImLjw0mNYgbSk3dnRK6kfeN+JwE6eKqaANBEj4FLk8nrleVw3iQyYveZquPIksx7u015X0lKshQSbxWetv3POHY6NZR6KmvxiumgjQSjeCKUjLFZpYGnr5AEtxij8e\\\\\\\\\\\\\\\/iRupu0YKw+zSYwDRLJRuuxAxzIdl42EfY70WUTAEYe0pClCvy6lEu5ynuHbQG6C0g9HZfMaqklefo1DX2xcTd8cmI8XrveOntCA8LKU1dDk\\\\\\\\\\\\\\\/tLAOY3PxcxF+0qk12xv1bdH316XOXMqQWUVHeFGlJxHyEfcFyXyOHZXbi4l6SqnyFj5uUWbhj7v2FNyLa1hmx47HLuuHL567J3fNn5Ghz0NjFjmwl\\\\\\\\\\\\\\\/FdnXds2NUiIsABUtJ2Qx\\\\\\\\\\\\\\\/u4oSjxeGLGlEpQ1CKkhBqxIC5P3IXibeMd7pMUUDF95+AXFrz7L+uruFZVtOHP93jU+cfGnjd9hjc2i4KbHtgwe0LjCBiCqYkF+BG8x3gmxb8FNiuSPdSNJsgdu3L4X7PMpdjfFaEVTIZ+OYaV+u1BZIu9Eo\\\\\\\\\\\\\\\/P13XuyBmp45C7D4fKi9ivE2F\\\\\\\\\\\\\\\/6XD1RAXrWkMimp\\\\\\\\\\\\\\\/FLHkl\\\\\\\\\\\\\\\/FxKNS3rqUt\\\\\\\\\\\\\\\/M3sPEtTM3uPJosNrzI1fWCz0r581x0OuBM8JUFnkPzlR836NniE6eghRoOwhB4J6y4R1EIBSlJcLDqBd0fOvKWLr+LpZ\\\\\\\\\\\\\\\/j2jbPf6KZ+YJW0vZK4jpatPpKd3cE6NkSWphRTk0arEEWFjEin74H3Wxh7Syr1pofOOOPjq9jCAMcRY0FoVXjg1xeI3r\\\\\\\\\\\\\\\/ZMguDozmOxmORn\\\\\\\\\\\\\\\/bKrrysjK1S4Xj6CHKxJLwGJWuuHj4rV\\\\\\\\\\\\\\\/1tEA7CGwmJfCZ6XPNan2PLgYh5sx2tH9Iew9MiUqC9XmySDd3a+kg2eMQT9YhY6jkEZ46vvaCMpP+I+IFqjPT6FkdwTnEDSHzpfIlbVUFZhNdVsezukqmRV7mNFq8tH9RioloQc8qJ1YEXp27W7de73KSOcQkLcmIlZ2KnGMlJOO\\\\\\\\\\\\\\\/EbG7P9YftwOcafCR2OKObLfbYM9PsmhSO8ykH0D4GNF6Z76d1OUxjJaQsc6JJuqFRujtjB3tt4YgTGMTaF5\\\\\\\\\\\\\\\/Gaz59OVeLxH85MJvO3D21WhWM+zzuu9lb3pxuaxlcawtbvqkszn+AVZhZ7iPz+CJLrKhh3XUPQ6DFFv4OmjCjLi720UaNLbz1TU8X7G6VMifxZ0OxnSNWPMjd2i7NOH4zZh9jCXM5JOhA8uEtYuiiuM\\\\\\\\\\\\\\\/K1ypYcUPxjYSQYpX6IRp9Zu2g2+ahe2CtULgAoqNYx3k1\\\\\\\\\\\\\\\/bOIw82d\\\\\\\\\\\\\\\/KafG2hC+WRC6YkxYYO4KxJEfjruB23hdJJ2t6KYmWK0Jpz9GKh4LkheqVHL6i3chCeLjmMH8Za5V43m8\\\\\\\\\\\\\\\/RVJxRUZYgcdfVAomxkReBnoTW\\\\\\\\\\\\\\\/kqnc5wr1MaPQTwKp0YnJWCtccHhC6lp4KIrWJCg5v+thZ\\\\\\\\\\\\\\\/1juYjV9BoSGJKVUa3yI\\\\\\\\\\\\\\\/MXAII+2o1H1AYjB9H6z4Dg+jOrR\\\\\\\\\\\\\\\/+jhi0iLczAFisCNJ6iKa5CgLPL00lD8Gv8JMCAZgaJ85f5TGCOiBz2rF0\\\\\\\\\\\\\\\/7v17OVrdSaCq0Vy6Oog5PSeBhigE7xCelN7NWAqdfSn3bUJUt6TwwKbqtBk6XsqVlFISE4O89fwT+0ddOAgLk3ntZgS1oQg4COOpBoY95KsMaqLaIbJGJ52enuP5EpV59GNGt89Tb\\\\\\\\\\\\\\\/5HKgE7R9RvkxMHiqPkGf3cVykyBpdstSBeJVwVL8RLeuMyvP4FlytrKTLVpSjlUFg20HbYmTwQKRsO8xDiK9BuJHMztgneTvjmm5VZKJV+0a88h8dzvW3DY8yRGiCWVDACzwIiX6YKQ8pHVTL8OnrXVBo+cfD+eS8GJZahsCLOcoDpNFw8I80hy7aJMRvzRl64eNS6w0YHP6azb52Fm8sE\\\\\\\\\\\\\\\/66A6nC0bJZR0H0\\\\\\\\\\\\\\\/4vT2\\\\\\\\\\\\\\\/7tpvakxUFn2\\\\\\\\\\\\\\\/aOPUx5MyUhsnM1gXC2DYlkQOQtWiBNvY56dDqN4ZIm\\\\\\\\\\\\\\\/zq4HW\\\\\\\\\\\\\\\/q9Id3jxwBFxZR9bR6inlQIpoPgQ\\\\\\\\\\\\\\\/25bEXKVfOmj\\\\\\\\\\\\\\\/Gb40e9VFT4ZmvGtfTSgEqPjzF0COz4RsgnsEJDDqrNko\\\\\\\\\\\\\\\/iDWRVYDZQHNjxbgZQsCvE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wM45cFpxejT7HsxB9rkjjg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022729ebd4a1587d2ee5f8c953af06c181509837b0c8caf3d0252c00231b0031d60\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/4\\\/e004095.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/4\\\/e004095.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004095\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004095\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004095\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}