{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jJGdB9sh43eibKDonTSsXQCJUz4+fwSQgwfzKo0afae3mn5WRgU\\\\\\\\\\\\\\\/PtYxOSOqVVeVTICpb\\\\\\\\\\\\\\\/tkBy7zT34VdD5LwJDWZK11JKJBz1GzxlcrT6LROvlWkTwnYBqrSprnafTnnEy2u\\\\\\\\\\\\\\\/NWcQXfd526x7mMVQo++CL32Mn67AnvOcpkuRlIycskuagVpsWHYbHh16OPInDd3IQdl5pyY3AEmxXm8zPXPoV2ews+u0zQ6XRfu4f+z2tqAbJ6cUflg\\\\\\\\\\\\\\\/GlrDjTxJNhhODbvFvlRSIW1ibELbur6Hdd9\\\\\\\\\\\\\\\/hBEXPK8Kr17utt\\\\\\\\\\\\\\\/fUCFZsinmAcp78iRrQE20nzsmJ\\\\\\\\\\\\\\\/OvNpFEmmIU7nb3V817A1tuYcAwa+sW7KV9SjD7T97QgpwN\\\\\\\\\\\\\\\/u3UwvyXSyYqVc4UdT2vWklt2I01D8kiXyGBgDu7n0HrnbtA2NhUmzQYH1iD7ntTzLm+XdK89dlZ4pyeaItxMMwsml4FLm9aS0hGxqkIB\\\\\\\\\\\\\\\/RvOvLlOpgqboGUo77Bro1laoQsTO2W6021te0I0jNRp0ShzBSs5Sjs6qQsF4hcsYkiWfBpDbBh2J7qMEffZ2trPF\\\\\\\\\\\\\\\/j0CpZgw4jb34vGn0Waxqi2KjmwhiIH75p8l7OJ1rTuN8BjykVyRlgqKrf5T4w1cafbx6aouJJCxH++ubnVHYGW+PlmG5JOee9JXSQ8YLc+RbuWGl6JsR1\\\\\\\\\\\\\\\/y6d8AI+zj\\\\\\\\\\\\\\\/QdafwFKNCk3ZMh3b0Lmjf4Bj\\\\\\\\\\\\\\\/q6KJbcYNnvIo3erPlyxt7k7PQbFoyJsGaL6ejr5xLHAsiGZldujFxXyAHE36mqK2424WPkyLE6U0S7Id4gQuunbApq3TQZHrSTp+ch5E1vJYZtHbeSpvTAMr1zt9ZUDb9K+aE7XSYeTyT4UbqAVMDhmyMmiRoPwS5y9hjiHlmmXKHJ3ehznzg2iokvCzjbfNTczmTBGCKdezoP\\\\\\\\\\\\\\\/mfh1VK8UyjFSDxibVOt+oUhcX9mWee8TuNEgOfEWWnJEIPaSX3yVxS7eedVxHUjZieYoMc3ukBl+G3mzJc\\\\\\\\\\\\\\\/JjT4c5bVe2hWjwXIyh4i6dtDaXvAE+oQ3KHgiXGnPzL9E9j9MklHNb7UUCAA1UIVq8r8LddTMX6la+zP9TXB9MBmmku2A4clIXVJeBjXylVf1A+5ND8i+4R6uXJQ974XE9irBW9NKcXqCnK377qC34RI3EgR8szdSwrDBUgMd9qdMr\\\\\\\\\\\\\\\/Xovd+BjuulIGOZGcT+iQuovx6G5WX0HRDImcs1e17Nr3COOIrXySgRz8pkqwZ9NKUNCWly5hxJzcAoVbHihI5xYuTMd1MKm4F+6pY4WG59WqQfEzlda+VN6jfcaRgNSjPEcdWRVjraLCJYNHOVGYKLUf0wDdlm5bt55C4n0IZVzCyekc3DMJWT4JrtF0kqwkyBgwIyLlTinH3Z1IaFdl1PaD7ujK9iS4aARcTsaOpF7Ka+d\\\\\\\\\\\\\\\/YtEzf2JPZWUiE4uCdRZFIo0dPqktF\\\\\\\\\\\\\\\/QW8fB1m5NMfSMy6I3KTI2I89i3jfIw7JHpdFzzpriBChNyJpUcZB1PXunj3ZEskv\\\\\\\\\\\\\\\/TR7RB8g+DDMdTPYb0mbW3StQFAxzpqLvMkyc17sVUroW0V0gahYN88Y2R36IYV0BHzM2pKHI6WTLmE91Y1TcPGCYjlR6T177YUkaDfLihifKoBbyMugqxaiIrKqvL0kN52HBthFX6rVyMY0tNQ6\\\\\\\\\\\\\\\/ljBA4mMDCwaqyLaARYYK2f3ScH8N2rq\\\\\\\\\\\\\\\/MeOwdiSSJI7bjSy9hjZAIZolMupRqEzXMF12ZwsweKnd+8TlVpmJnUnKCZHTJA4p9lAKGgQv23v+MO\\\\\\\\\\\\\\\/ywvdWpS9TUWk2nJA0BxmXO3+JQSTT+vOuPz5zc8rwRC1foE312gxI8kHaqoVh80LZrNTgNzGCC5Ne4++tUUFWSz7xDP6y4lr9ohz9RG15s+Zu5rvbOEbARHDC\\\\\\\\\\\\\\\/P1p0d6Yx5A2R+aZfMKF34oNBLBMxle\\\\\\\\\\\\\\\/cxwMNWyH4HcHsntoIjF142cVmu5opEFQDZ45mvNI10dLf0BJboSzzN\\\\\\\\\\\\\\\/V6HbJPcotk64NaNWo3mtpn+g5xaUhfnIWkbybClrHJ08ukw7c54IEgAo8j4uG72KpSd8vchlu5SX0HgZH+nvFuXdjmCW\\\\\\\\\\\\\\\/0THblBszgWXHut4gwML02tR69LiXGTWmWf09YJ6QEHLBumwHZ3c3TWMv6uumi8n3p53uXgCqsqKW5cxsH10Jgxs2EwXaeAoC+SdP+yNlApFeHfdJOYiW1vmqy99\\\\\\\\\\\\\\\/4dVUVxmzalEkLieZMlbLRR2dq2Q\\\\\\\\\\\\\\\/KK\\\\\\\\\\\\\\\/FHK\\\\\\\\\\\\\\\/DZfA0JQjfvnV+Wj1Szn9+YwtZh87wkORYN5IqDeA0yoO\\\\\\\\\\\\\\\/JUicpV3sbScF6OYQRKGX5BEJcKP82v4INplGtCj0DSfmip2TaHaqybOBlpR8M3VTNEDtEOWAKSHcEJOo6P4y6rqU5QYRFeLXQedHM64czOk1DvVpUtlWH9hlnjrGARtE7U9HlKOBTGnitTYNj71ULgwaFfMTpYvneJyQc9KF8\\\\\\\\\\\\\\\/NlC3a6wyit2KQExX68yC66Jl7NwmZ\\\\\\\\\\\\\\\/8dAjHlyjwVlEFFeiJqJNpzlGqN7QlhRQ1Lzd7BKcTPv3LAZMquov7YR38h2pLFCImuJaQvCunrnW\\\\\\\\\\\\\\\/3QxxPUN8ObFm45abBvwYdA+y5DzI7YtIDad4JY0M=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022HC81bi52iZmJ2WbIzOyFdg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b4e04870ccb554b02564a61ce0495ba3af6b8d0ea10b66058213ec0f593108af\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/4\\\/e004149.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/4\\\/e004149.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004149\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004149\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004149\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}